Comparison of the efficacy of Tacrolimus 0.1% ointment and Tacrolimus 0.1% plus topical pseudocatalase/superoxide dismutase gel in children with limited vitiligo: a randomized controlled trial
Background The pathogenesis of vitiligo is complex and multifactorial, accumulating evidence of increased oxidative stress and reduction in catalase levels in vitiligo patients has been shown, hence, pseudocatalase/superoxide dismutase (PSD) gel has been used as treatment option for vitiligo. Aim To...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2022-01-01
|
| Series: | Journal of Dermatological Treatment |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/09546634.2020.1729952 |
| _version_ | 1797683596800032768 |
|---|---|
| author | Diala M. Alshiyab Firas A. Al-qarqaz Jihan M. Muhaidat Yousef S. Alkhader Ruba F. Al-sheyab Sala I. Jafaar |
| author_facet | Diala M. Alshiyab Firas A. Al-qarqaz Jihan M. Muhaidat Yousef S. Alkhader Ruba F. Al-sheyab Sala I. Jafaar |
| author_sort | Diala M. Alshiyab |
| collection | DOAJ |
| description | Background The pathogenesis of vitiligo is complex and multifactorial, accumulating evidence of increased oxidative stress and reduction in catalase levels in vitiligo patients has been shown, hence, pseudocatalase/superoxide dismutase (PSD) gel has been used as treatment option for vitiligo. Aim To assesses the synergic effect of PSD when combines with Tacrolimus 0.1% ointment versus Tacrolimus 0.1% alone. Method A randomized controlled trial that included 49 children with vitiligo with limited area (10% or less). Patients were randomized into two groups: Group 1 (24 patients) were treated only with Tacrolimus 0.1% ointment whereas Group 2 (25 patients) were treated with Tacrolimus 0.1% ointment plus PSD. Degree of repigmentation compared to baseline was assessed at 3, 6, and 9 months. Results The median age was 10.05 years (range 2–18). The percentages of pigmentation on 3, 6, and 9 months for Group 1 were 23.9%, 40.4%, and 60%, respectively and for Group 2 were 23.2%, 40.7%, and 62.4%, respectively. There was no significant difference according to repigmentation percentages between the two groups (p > .86, p > .97, and p > .78, respectively). Conclusions The results showed that the addition of PSD to Tacrolimus ointment in children with limited vitiligo was not associated with any therapeutic benefit. |
| first_indexed | 2024-03-12T00:16:46Z |
| format | Article |
| id | doaj.art-41d98200043f443b8ad09edd721297c7 |
| institution | Directory Open Access Journal |
| issn | 0954-6634 1471-1753 |
| language | English |
| last_indexed | 2024-03-12T00:16:46Z |
| publishDate | 2022-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Dermatological Treatment |
| spelling | doaj.art-41d98200043f443b8ad09edd721297c72023-09-15T14:23:05ZengTaylor & Francis GroupJournal of Dermatological Treatment0954-66341471-17532022-01-0133114614910.1080/09546634.2020.17299521729952Comparison of the efficacy of Tacrolimus 0.1% ointment and Tacrolimus 0.1% plus topical pseudocatalase/superoxide dismutase gel in children with limited vitiligo: a randomized controlled trialDiala M. Alshiyab0Firas A. Al-qarqaz1Jihan M. Muhaidat2Yousef S. Alkhader3Ruba F. Al-sheyab4Sala I. Jafaar5Department of Dermatology, Faculty of Medicine, Jordan University of Science and TechnologyDepartment of Dermatology, Faculty of Medicine, Jordan University of Science and TechnologyDepartment of Dermatology, Faculty of Medicine, Jordan University of Science and TechnologyDepartment of Public Health, Community Medicine, Jordan University of Science and TechnologyDepartment of Dermatology, Faculty of Medicine, Jordan University of Science and TechnologyDepartment of Dermatology, Faculty of Medicine, Jordan University of Science and TechnologyBackground The pathogenesis of vitiligo is complex and multifactorial, accumulating evidence of increased oxidative stress and reduction in catalase levels in vitiligo patients has been shown, hence, pseudocatalase/superoxide dismutase (PSD) gel has been used as treatment option for vitiligo. Aim To assesses the synergic effect of PSD when combines with Tacrolimus 0.1% ointment versus Tacrolimus 0.1% alone. Method A randomized controlled trial that included 49 children with vitiligo with limited area (10% or less). Patients were randomized into two groups: Group 1 (24 patients) were treated only with Tacrolimus 0.1% ointment whereas Group 2 (25 patients) were treated with Tacrolimus 0.1% ointment plus PSD. Degree of repigmentation compared to baseline was assessed at 3, 6, and 9 months. Results The median age was 10.05 years (range 2–18). The percentages of pigmentation on 3, 6, and 9 months for Group 1 were 23.9%, 40.4%, and 60%, respectively and for Group 2 were 23.2%, 40.7%, and 62.4%, respectively. There was no significant difference according to repigmentation percentages between the two groups (p > .86, p > .97, and p > .78, respectively). Conclusions The results showed that the addition of PSD to Tacrolimus ointment in children with limited vitiligo was not associated with any therapeutic benefit.http://dx.doi.org/10.1080/09546634.2020.1729952vitiligotacrolimus 0.1%pseudocatalase/superoxide dismutase (psd)catalase |
| spellingShingle | Diala M. Alshiyab Firas A. Al-qarqaz Jihan M. Muhaidat Yousef S. Alkhader Ruba F. Al-sheyab Sala I. Jafaar Comparison of the efficacy of Tacrolimus 0.1% ointment and Tacrolimus 0.1% plus topical pseudocatalase/superoxide dismutase gel in children with limited vitiligo: a randomized controlled trial Journal of Dermatological Treatment vitiligo tacrolimus 0.1% pseudocatalase/superoxide dismutase (psd) catalase |
| title | Comparison of the efficacy of Tacrolimus 0.1% ointment and Tacrolimus 0.1% plus topical pseudocatalase/superoxide dismutase gel in children with limited vitiligo: a randomized controlled trial |
| title_full | Comparison of the efficacy of Tacrolimus 0.1% ointment and Tacrolimus 0.1% plus topical pseudocatalase/superoxide dismutase gel in children with limited vitiligo: a randomized controlled trial |
| title_fullStr | Comparison of the efficacy of Tacrolimus 0.1% ointment and Tacrolimus 0.1% plus topical pseudocatalase/superoxide dismutase gel in children with limited vitiligo: a randomized controlled trial |
| title_full_unstemmed | Comparison of the efficacy of Tacrolimus 0.1% ointment and Tacrolimus 0.1% plus topical pseudocatalase/superoxide dismutase gel in children with limited vitiligo: a randomized controlled trial |
| title_short | Comparison of the efficacy of Tacrolimus 0.1% ointment and Tacrolimus 0.1% plus topical pseudocatalase/superoxide dismutase gel in children with limited vitiligo: a randomized controlled trial |
| title_sort | comparison of the efficacy of tacrolimus 0 1 ointment and tacrolimus 0 1 plus topical pseudocatalase superoxide dismutase gel in children with limited vitiligo a randomized controlled trial |
| topic | vitiligo tacrolimus 0.1% pseudocatalase/superoxide dismutase (psd) catalase |
| url | http://dx.doi.org/10.1080/09546634.2020.1729952 |
| work_keys_str_mv | AT dialamalshiyab comparisonoftheefficacyoftacrolimus01ointmentandtacrolimus01plustopicalpseudocatalasesuperoxidedismutasegelinchildrenwithlimitedvitiligoarandomizedcontrolledtrial AT firasaalqarqaz comparisonoftheefficacyoftacrolimus01ointmentandtacrolimus01plustopicalpseudocatalasesuperoxidedismutasegelinchildrenwithlimitedvitiligoarandomizedcontrolledtrial AT jihanmmuhaidat comparisonoftheefficacyoftacrolimus01ointmentandtacrolimus01plustopicalpseudocatalasesuperoxidedismutasegelinchildrenwithlimitedvitiligoarandomizedcontrolledtrial AT yousefsalkhader comparisonoftheefficacyoftacrolimus01ointmentandtacrolimus01plustopicalpseudocatalasesuperoxidedismutasegelinchildrenwithlimitedvitiligoarandomizedcontrolledtrial AT rubafalsheyab comparisonoftheefficacyoftacrolimus01ointmentandtacrolimus01plustopicalpseudocatalasesuperoxidedismutasegelinchildrenwithlimitedvitiligoarandomizedcontrolledtrial AT salaijafaar comparisonoftheefficacyoftacrolimus01ointmentandtacrolimus01plustopicalpseudocatalasesuperoxidedismutasegelinchildrenwithlimitedvitiligoarandomizedcontrolledtrial |