Genome-wide SNP analysis of Japanese Thoroughbred racehorses.
The domestication process of plants and animals typically involves intense inbreeding and directional selection for various traits. Here, we genotyped 370 Japanese Thoroughbred horses using the recently developed 670k SNP array and performed various genome-wide analysis also using genotype data of o...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2019-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0218407 |
| _version_ | 1818726292813512704 |
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| author | Jeffrey A Fawcett Fumio Sato Takahiro Sakamoto Watal M Iwasaki Teruaki Tozaki Hideki Innan |
| author_facet | Jeffrey A Fawcett Fumio Sato Takahiro Sakamoto Watal M Iwasaki Teruaki Tozaki Hideki Innan |
| author_sort | Jeffrey A Fawcett |
| collection | DOAJ |
| description | The domestication process of plants and animals typically involves intense inbreeding and directional selection for various traits. Here, we genotyped 370 Japanese Thoroughbred horses using the recently developed 670k SNP array and performed various genome-wide analysis also using genotype data of other horse breeds. We identified a number of regions showing interesting patterns of polymorphisms. For instance, the region containing the MC1R locus associated with chestnut coat color may have been targeted by selection for a different mutation much earlier on than the recent selection for chestnut color. We also identified regions that show signatures of selection specific to Thoroughbreds. In addition, we found that intense inbreeding early in the history of the Thoroughbred breed and also before the formation of the breed has a significant impact on the genomic architecture of modern Thoroughbreds. Our study demonstrates that the horse 670k array can be utilized to gain important insight into the domestication process of horses and to understand the genetic basis of the phenotypic diversity in horses. |
| first_indexed | 2024-12-17T21:55:54Z |
| format | Article |
| id | doaj.art-41da38480a074175b3423e55346bc168 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-17T21:55:54Z |
| publishDate | 2019-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-41da38480a074175b3423e55346bc1682022-12-21T21:31:07ZengPublic Library of Science (PLoS)PLoS ONE1932-62032019-01-01147e021840710.1371/journal.pone.0218407Genome-wide SNP analysis of Japanese Thoroughbred racehorses.Jeffrey A FawcettFumio SatoTakahiro SakamotoWatal M IwasakiTeruaki TozakiHideki InnanThe domestication process of plants and animals typically involves intense inbreeding and directional selection for various traits. Here, we genotyped 370 Japanese Thoroughbred horses using the recently developed 670k SNP array and performed various genome-wide analysis also using genotype data of other horse breeds. We identified a number of regions showing interesting patterns of polymorphisms. For instance, the region containing the MC1R locus associated with chestnut coat color may have been targeted by selection for a different mutation much earlier on than the recent selection for chestnut color. We also identified regions that show signatures of selection specific to Thoroughbreds. In addition, we found that intense inbreeding early in the history of the Thoroughbred breed and also before the formation of the breed has a significant impact on the genomic architecture of modern Thoroughbreds. Our study demonstrates that the horse 670k array can be utilized to gain important insight into the domestication process of horses and to understand the genetic basis of the phenotypic diversity in horses.https://doi.org/10.1371/journal.pone.0218407 |
| spellingShingle | Jeffrey A Fawcett Fumio Sato Takahiro Sakamoto Watal M Iwasaki Teruaki Tozaki Hideki Innan Genome-wide SNP analysis of Japanese Thoroughbred racehorses. PLoS ONE |
| title | Genome-wide SNP analysis of Japanese Thoroughbred racehorses. |
| title_full | Genome-wide SNP analysis of Japanese Thoroughbred racehorses. |
| title_fullStr | Genome-wide SNP analysis of Japanese Thoroughbred racehorses. |
| title_full_unstemmed | Genome-wide SNP analysis of Japanese Thoroughbred racehorses. |
| title_short | Genome-wide SNP analysis of Japanese Thoroughbred racehorses. |
| title_sort | genome wide snp analysis of japanese thoroughbred racehorses |
| url | https://doi.org/10.1371/journal.pone.0218407 |
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