Gut microbiota shapes social dominance through modulating HDAC2 in the medial prefrontal cortex
Summary: Social dominance is a ubiquitous phenomenon among social animals, including humans. To date, individual attributes leading to dominance (after a contest) remain largely elusive. Here, we report that socially dominant rats can be distinguished from subordinates based on their intestinal micr...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-03-01
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| Series: | Cell Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S221112472200211X |
| _version_ | 1819349513750446080 |
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| author | Tian Wang Jinchun Xu Yi Xu Jie Xiao Nanxi Bi Xiaozhen Gu Hui-Li Wang |
| author_facet | Tian Wang Jinchun Xu Yi Xu Jie Xiao Nanxi Bi Xiaozhen Gu Hui-Li Wang |
| author_sort | Tian Wang |
| collection | DOAJ |
| description | Summary: Social dominance is a ubiquitous phenomenon among social animals, including humans. To date, individual attributes leading to dominance (after a contest) remain largely elusive. Here, we report that socially dominant rats can be distinguished from subordinates based on their intestinal microbiota. When dysbiosis is induced, rats are predisposed to a subordinate state, while dysbiotic rats reclaim social dominance following microbiota transplantation. Winning hosts are characterized by core microbes, a majority of which are associated with butyrate production, and the sole colonization of Clostridium butyricum is sufficient to restore dominance. Regarding molecular aspects, a histone deacetylase, HDAC2, is responsive to microbial status and mediates competition outcome; however, this occurs only in a restricted population of cells in the medial prefrontal cortex (mPFC). Furthermore, HDAC2 acts by modulating synaptic activity in mPFC. Together, these findings uncover a link between commensals and host dominance, providing insight into the gut-brain mechanisms underlying dominance determination. |
| first_indexed | 2024-12-24T19:01:43Z |
| format | Article |
| id | doaj.art-41dc331dda704bb69a90822e4e3ae5ab |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-12-24T19:01:43Z |
| publishDate | 2022-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-41dc331dda704bb69a90822e4e3ae5ab2022-12-21T16:43:11ZengElsevierCell Reports2211-12472022-03-013810110478Gut microbiota shapes social dominance through modulating HDAC2 in the medial prefrontal cortexTian Wang0Jinchun Xu1Yi Xu2Jie Xiao3Nanxi Bi4Xiaozhen Gu5Hui-Li Wang6School of Food and Bioengineering, Hefei University of Technology, Hefei 230009, ChinaSchool of Food and Bioengineering, Hefei University of Technology, Hefei 230009, ChinaSchool of Food and Bioengineering, Hefei University of Technology, Hefei 230009, China; Engineering Research Center of Bio-process, Ministry of Education, Hefei University of Technology, 193 Tunxi Road, Hefei 230009, China; Corresponding authorSchool of Food and Bioengineering, Hefei University of Technology, Hefei 230009, ChinaSchool of Food and Bioengineering, Hefei University of Technology, Hefei 230009, ChinaSchool of Food and Bioengineering, Hefei University of Technology, Hefei 230009, ChinaSchool of Food and Bioengineering, Hefei University of Technology, Hefei 230009, China; Engineering Research Center of Bio-process, Ministry of Education, Hefei University of Technology, 193 Tunxi Road, Hefei 230009, China; Corresponding authorSummary: Social dominance is a ubiquitous phenomenon among social animals, including humans. To date, individual attributes leading to dominance (after a contest) remain largely elusive. Here, we report that socially dominant rats can be distinguished from subordinates based on their intestinal microbiota. When dysbiosis is induced, rats are predisposed to a subordinate state, while dysbiotic rats reclaim social dominance following microbiota transplantation. Winning hosts are characterized by core microbes, a majority of which are associated with butyrate production, and the sole colonization of Clostridium butyricum is sufficient to restore dominance. Regarding molecular aspects, a histone deacetylase, HDAC2, is responsive to microbial status and mediates competition outcome; however, this occurs only in a restricted population of cells in the medial prefrontal cortex (mPFC). Furthermore, HDAC2 acts by modulating synaptic activity in mPFC. Together, these findings uncover a link between commensals and host dominance, providing insight into the gut-brain mechanisms underlying dominance determination.http://www.sciencedirect.com/science/article/pii/S221112472200211Xsocial dominancegut microbiotaHDAC2sodium butyratemedial prefrontal cortex |
| spellingShingle | Tian Wang Jinchun Xu Yi Xu Jie Xiao Nanxi Bi Xiaozhen Gu Hui-Li Wang Gut microbiota shapes social dominance through modulating HDAC2 in the medial prefrontal cortex Cell Reports social dominance gut microbiota HDAC2 sodium butyrate medial prefrontal cortex |
| title | Gut microbiota shapes social dominance through modulating HDAC2 in the medial prefrontal cortex |
| title_full | Gut microbiota shapes social dominance through modulating HDAC2 in the medial prefrontal cortex |
| title_fullStr | Gut microbiota shapes social dominance through modulating HDAC2 in the medial prefrontal cortex |
| title_full_unstemmed | Gut microbiota shapes social dominance through modulating HDAC2 in the medial prefrontal cortex |
| title_short | Gut microbiota shapes social dominance through modulating HDAC2 in the medial prefrontal cortex |
| title_sort | gut microbiota shapes social dominance through modulating hdac2 in the medial prefrontal cortex |
| topic | social dominance gut microbiota HDAC2 sodium butyrate medial prefrontal cortex |
| url | http://www.sciencedirect.com/science/article/pii/S221112472200211X |
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