Rosuvastatin and co-enzyme Q10 improve high-fat and high-fructose diet-induced metabolic syndrome in rats via ameliorating inflammatory and oxidative burden
The prevalence of metabolic syndrome (MetS) has been rising alarmingly and it has now become a global concern causing an enormous economic burden on the health care system. MetS is generally linked to complications in lipid metabolism, oxidative stress and low grade inflammation. The aim of the curr...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-09-01
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| Series: | Biomedicine & Pharmacotherapy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332222009155 |
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| author | Mohamed Ibrahim Mohamed Fahmy Rabab Hamed Sayed Muhammad Farag El-Yamany Reham El-Naggar Hesham A. Eliwa |
| author_facet | Mohamed Ibrahim Mohamed Fahmy Rabab Hamed Sayed Muhammad Farag El-Yamany Reham El-Naggar Hesham A. Eliwa |
| author_sort | Mohamed Ibrahim Mohamed Fahmy |
| collection | DOAJ |
| description | The prevalence of metabolic syndrome (MetS) has been rising alarmingly and it has now become a global concern causing an enormous economic burden on the health care system. MetS is generally linked to complications in lipid metabolism, oxidative stress and low grade inflammation. The aim of the current study was to evaluate the effect of rosuvastatin, co-enzyme Q10 (CoQ10), and their combination on blood pressure, blood sugar, dyslipidemia, and liver function in rats with MetS induced by high fructose and high fat diet (HF-HFD) and the possible underlying mechanism. Oral administration of rosuvastatin (10 mg/kg/day), CoQ10 (10 mg/kg/day) and their combination for 4 weeks in HF-HFD-fed rats elevated serum high density lipoprotein and reduced glutathione. On the other hand, treatment with rosuvastatin, CoQ10 or their combination decreased the serum levels of malondialdehyde, triglycerides, total cholesterol, and low density lipoprotein-cholesterol as well as systolic blood pressure, body weight and fasting blood glucose level. In addition, the drugs or their combination declined serum pro-inflammatory cytokines, namely tumor necrosis factor-α and interleukin-1β. In conclusion, our results showed that rosuvastatin or CoQ10 protected against HF-HFD-induced MetS through the regulation of dyslipidemia, elevated blood glucose, elevated blood pressure, antioxidant defenses and inflammatory response. Rosuvastatin or CoQ10 also alleviated the impairment of liver function that was induced by HF-HFD. Interestingly, CoQ10 augmented rosuvastatin's effect in ameliorating MetS, via exerting synergistic modulatory effects on oxidative stress and inflammation. Thus, rosuvastatin and CoQ10 combination therapy may have possible applications in ameliorating metabolic disorders. |
| first_indexed | 2024-04-11T14:13:22Z |
| format | Article |
| id | doaj.art-41dd4efeb9b14a1397e9649e4fac2bbe |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-04-11T14:13:22Z |
| publishDate | 2022-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-41dd4efeb9b14a1397e9649e4fac2bbe2022-12-22T04:19:37ZengElsevierBiomedicine & Pharmacotherapy0753-33222022-09-01153113526Rosuvastatin and co-enzyme Q10 improve high-fat and high-fructose diet-induced metabolic syndrome in rats via ameliorating inflammatory and oxidative burdenMohamed Ibrahim Mohamed Fahmy0Rabab Hamed Sayed1Muhammad Farag El-Yamany2Reham El-Naggar3Hesham A. Eliwa4Department of Pharmacology and Toxicology, Faculty of Pharmacy, Heliopolis University for sustainable development, Cairo, EgyptDepartment of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Egypt; Correspondence to: Faculty of Pharmacy, Kasr El Aini St., 11562 Cairo, Egypt.Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, EgyptDepartment of Pharmacology and Toxicology, Faculty of Pharmacy, Misr University for Science and Technology (MUST), EgyptDepartment of Pharmacology and Toxicology, Faculty of Pharmacy, Misr University for Science and Technology (MUST), EgyptThe prevalence of metabolic syndrome (MetS) has been rising alarmingly and it has now become a global concern causing an enormous economic burden on the health care system. MetS is generally linked to complications in lipid metabolism, oxidative stress and low grade inflammation. The aim of the current study was to evaluate the effect of rosuvastatin, co-enzyme Q10 (CoQ10), and their combination on blood pressure, blood sugar, dyslipidemia, and liver function in rats with MetS induced by high fructose and high fat diet (HF-HFD) and the possible underlying mechanism. Oral administration of rosuvastatin (10 mg/kg/day), CoQ10 (10 mg/kg/day) and their combination for 4 weeks in HF-HFD-fed rats elevated serum high density lipoprotein and reduced glutathione. On the other hand, treatment with rosuvastatin, CoQ10 or their combination decreased the serum levels of malondialdehyde, triglycerides, total cholesterol, and low density lipoprotein-cholesterol as well as systolic blood pressure, body weight and fasting blood glucose level. In addition, the drugs or their combination declined serum pro-inflammatory cytokines, namely tumor necrosis factor-α and interleukin-1β. In conclusion, our results showed that rosuvastatin or CoQ10 protected against HF-HFD-induced MetS through the regulation of dyslipidemia, elevated blood glucose, elevated blood pressure, antioxidant defenses and inflammatory response. Rosuvastatin or CoQ10 also alleviated the impairment of liver function that was induced by HF-HFD. Interestingly, CoQ10 augmented rosuvastatin's effect in ameliorating MetS, via exerting synergistic modulatory effects on oxidative stress and inflammation. Thus, rosuvastatin and CoQ10 combination therapy may have possible applications in ameliorating metabolic disorders.http://www.sciencedirect.com/science/article/pii/S0753332222009155Metabolic syndromeRosuvastatinCo-enzyme Q10HF-HFDOxidative stressInflammation |
| spellingShingle | Mohamed Ibrahim Mohamed Fahmy Rabab Hamed Sayed Muhammad Farag El-Yamany Reham El-Naggar Hesham A. Eliwa Rosuvastatin and co-enzyme Q10 improve high-fat and high-fructose diet-induced metabolic syndrome in rats via ameliorating inflammatory and oxidative burden Biomedicine & Pharmacotherapy Metabolic syndrome Rosuvastatin Co-enzyme Q10 HF-HFD Oxidative stress Inflammation |
| title | Rosuvastatin and co-enzyme Q10 improve high-fat and high-fructose diet-induced metabolic syndrome in rats via ameliorating inflammatory and oxidative burden |
| title_full | Rosuvastatin and co-enzyme Q10 improve high-fat and high-fructose diet-induced metabolic syndrome in rats via ameliorating inflammatory and oxidative burden |
| title_fullStr | Rosuvastatin and co-enzyme Q10 improve high-fat and high-fructose diet-induced metabolic syndrome in rats via ameliorating inflammatory and oxidative burden |
| title_full_unstemmed | Rosuvastatin and co-enzyme Q10 improve high-fat and high-fructose diet-induced metabolic syndrome in rats via ameliorating inflammatory and oxidative burden |
| title_short | Rosuvastatin and co-enzyme Q10 improve high-fat and high-fructose diet-induced metabolic syndrome in rats via ameliorating inflammatory and oxidative burden |
| title_sort | rosuvastatin and co enzyme q10 improve high fat and high fructose diet induced metabolic syndrome in rats via ameliorating inflammatory and oxidative burden |
| topic | Metabolic syndrome Rosuvastatin Co-enzyme Q10 HF-HFD Oxidative stress Inflammation |
| url | http://www.sciencedirect.com/science/article/pii/S0753332222009155 |
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