Decision rule for stratification of patients with chronic heart failure of functional class II and III
The aim of the study was focused on the development of a decision rule for classifying patients as functional class (FC) II or III of chronic heart failure (CHF) by discriminant analysis with inflammatory markers.Materials and methods. The study included CHF patients (n = 61) of both sexes. Accordin...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Siberian State Medical University (Tomsk)
2020-04-01
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| Series: | Бюллетень сибирской медицины |
| Subjects: | |
| Online Access: | https://bulletin.ssmu.ru/jour/article/view/2689 |
| _version_ | 1827991433409200128 |
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| author | E. V. Samoilova M. A. Fatova D. R. Mindzaev I. V. Zhitareva C. N. Nasonova I. V. Zhirov C. N. Tereschenko A. A. Korotaeva |
| author_facet | E. V. Samoilova M. A. Fatova D. R. Mindzaev I. V. Zhitareva C. N. Nasonova I. V. Zhirov C. N. Tereschenko A. A. Korotaeva |
| author_sort | E. V. Samoilova |
| collection | DOAJ |
| description | The aim of the study was focused on the development of a decision rule for classifying patients as functional class (FC) II or III of chronic heart failure (CHF) by discriminant analysis with inflammatory markers.Materials and methods. The study included CHF patients (n = 61) of both sexes. According to symptom severity, they were assigned to FC II (n = 20) and III (n = 41). In addition to conventional clinical and biochemical parameters to evaluate a patient’s state, parameters characterizing inflammation (IL-6, soluble IL-6 receptor, sgp130) were used. Statistically significant differences were revealed with the use of Mann – Whitney U test, Student’s t-test, Pearson’s χ2 test and Fisher’s exact test. Discriminant analysis was employed to formulate the decision rule. Receiver Operating Characteristic (ROC) analysis was used to evaluate the quality of the developed diagnostic test. The results were considered statistically significant at p < 0.05.Results. Discriminant analysis included significantly different variables (age, brain natriuretic peptide, sgp130, CHF etiology, ischemic heart disease) and additional clinically important variables (diastolic and systolic arterial blood pressure (BP), IL-6). The decision rule for assigning patients to different CHF FC was developed. The optimum cut-off value was found with the use of the ROC curve with a sensitivity of 75.6% and specificity of 85%.Conclusion. The decision rule for assigning CHF patients to FC II or III was developed using discriminant analysis. In addition to conventional clinical parameters, the model included the ones reflecting inflammatory processes (IL-6 and sgp130). ROC analysis revealed high quality of the model. |
| first_indexed | 2024-04-10T01:05:08Z |
| format | Article |
| id | doaj.art-41dd5bbb0c51418185ca6530d7ebf82c |
| institution | Directory Open Access Journal |
| issn | 1682-0363 1819-3684 |
| language | English |
| last_indexed | 2024-04-10T01:05:08Z |
| publishDate | 2020-04-01 |
| publisher | Siberian State Medical University (Tomsk) |
| record_format | Article |
| series | Бюллетень сибирской медицины |
| spelling | doaj.art-41dd5bbb0c51418185ca6530d7ebf82c2023-03-13T09:58:26ZengSiberian State Medical University (Tomsk)Бюллетень сибирской медицины1682-03631819-36842020-04-0119110110710.20538/1682-0363-2020-1-101-1071602Decision rule for stratification of patients with chronic heart failure of functional class II and IIIE. V. Samoilova0M. A. Fatova1D. R. Mindzaev2I. V. Zhitareva3C. N. Nasonova4I. V. Zhirov5C. N. Tereschenko6A. A. Korotaeva7Научный медицинский исследовательский центр (НМИЦ) кардиологииРоссийский национальный исследовательский медицинский университет (РНИМУ) имени Н.И. ПироговаНаучный медицинский исследовательский центр (НМИЦ) кардиологииРоссийский национальный исследовательский медицинский университет (РНИМУ) имени Н.И. ПироговаНаучный медицинский исследовательский центр (НМИЦ) кардиологииНаучный медицинский исследовательский центр (НМИЦ) кардиологииНаучный медицинский исследовательский центр (НМИЦ) кардиологииНаучный медицинский исследовательский центр (НМИЦ) кардиологииThe aim of the study was focused on the development of a decision rule for classifying patients as functional class (FC) II or III of chronic heart failure (CHF) by discriminant analysis with inflammatory markers.Materials and methods. The study included CHF patients (n = 61) of both sexes. According to symptom severity, they were assigned to FC II (n = 20) and III (n = 41). In addition to conventional clinical and biochemical parameters to evaluate a patient’s state, parameters characterizing inflammation (IL-6, soluble IL-6 receptor, sgp130) were used. Statistically significant differences were revealed with the use of Mann – Whitney U test, Student’s t-test, Pearson’s χ2 test and Fisher’s exact test. Discriminant analysis was employed to formulate the decision rule. Receiver Operating Characteristic (ROC) analysis was used to evaluate the quality of the developed diagnostic test. The results were considered statistically significant at p < 0.05.Results. Discriminant analysis included significantly different variables (age, brain natriuretic peptide, sgp130, CHF etiology, ischemic heart disease) and additional clinically important variables (diastolic and systolic arterial blood pressure (BP), IL-6). The decision rule for assigning patients to different CHF FC was developed. The optimum cut-off value was found with the use of the ROC curve with a sensitivity of 75.6% and specificity of 85%.Conclusion. The decision rule for assigning CHF patients to FC II or III was developed using discriminant analysis. In addition to conventional clinical parameters, the model included the ones reflecting inflammatory processes (IL-6 and sgp130). ROC analysis revealed high quality of the model.https://bulletin.ssmu.ru/jour/article/view/2689хроническая сердечная недостаточностьинтерлейкин 6sgp130решающее правилодискриминантный анализ |
| spellingShingle | E. V. Samoilova M. A. Fatova D. R. Mindzaev I. V. Zhitareva C. N. Nasonova I. V. Zhirov C. N. Tereschenko A. A. Korotaeva Decision rule for stratification of patients with chronic heart failure of functional class II and III Бюллетень сибирской медицины хроническая сердечная недостаточность интерлейкин 6 sgp130 решающее правило дискриминантный анализ |
| title | Decision rule for stratification of patients with chronic heart failure of functional class II and III |
| title_full | Decision rule for stratification of patients with chronic heart failure of functional class II and III |
| title_fullStr | Decision rule for stratification of patients with chronic heart failure of functional class II and III |
| title_full_unstemmed | Decision rule for stratification of patients with chronic heart failure of functional class II and III |
| title_short | Decision rule for stratification of patients with chronic heart failure of functional class II and III |
| title_sort | decision rule for stratification of patients with chronic heart failure of functional class ii and iii |
| topic | хроническая сердечная недостаточность интерлейкин 6 sgp130 решающее правило дискриминантный анализ |
| url | https://bulletin.ssmu.ru/jour/article/view/2689 |
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