Assessment of tuberculosis biomarkers in paratuberculosis-infected cattle
Mycobacterium bovis and Mycobacterium avium subsp. paratuberculosis, respectively the causative agents of bovine tuberculosis (bTB) and bovine paratuberculosis (PTB), share a high number of antigenic proteins. This characteristics makes the differential diagnosis of the diseases difficult. The inter...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Sciendo
2023-03-01
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| Series: | Journal of Veterinary Research |
| Subjects: | |
| Online Access: | https://doi.org/10.2478/jvetres-2023-0007 |
| _version_ | 1797848557557907456 |
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| author | Klepp Laura I. Colombatti María A. Moyano Roberto D. Romano María I. Malovrh Tadej Ocepek Matjaž Blanco Federico C. Bigi Fabiana |
| author_facet | Klepp Laura I. Colombatti María A. Moyano Roberto D. Romano María I. Malovrh Tadej Ocepek Matjaž Blanco Federico C. Bigi Fabiana |
| author_sort | Klepp Laura I. |
| collection | DOAJ |
| description | Mycobacterium bovis and Mycobacterium avium subsp. paratuberculosis, respectively the causative agents of bovine tuberculosis (bTB) and bovine paratuberculosis (PTB), share a high number of antigenic proteins. This characteristics makes the differential diagnosis of the diseases difficult. The interferon gamma (IFN-γ), C-X-C motif chemokine ligand 10 (CXCL10), matrix metallopeptidase 9 (MMP9), interleukin 22 (IL-22) and thrombospondin 1 (THBS1) bovine genes have already been shown to be accurate transcriptional biomarkers of bTB. In order to improve the diagnosis of bTB and PTB, in the present study we evaluated the risk of false positivity of these bTB biomarkers in cattle with PTB. |
| first_indexed | 2024-04-09T18:29:37Z |
| format | Article |
| id | doaj.art-41de6ab7ccca4d999bf8cd06200e531b |
| institution | Directory Open Access Journal |
| issn | 2450-8608 |
| language | English |
| last_indexed | 2024-04-09T18:29:37Z |
| publishDate | 2023-03-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Journal of Veterinary Research |
| spelling | doaj.art-41de6ab7ccca4d999bf8cd06200e531b2023-04-11T17:19:26ZengSciendoJournal of Veterinary Research2450-86082023-03-01671556010.2478/jvetres-2023-0007Assessment of tuberculosis biomarkers in paratuberculosis-infected cattleKlepp Laura I.0Colombatti María A.1Moyano Roberto D.2Romano María I.3Malovrh Tadej4Ocepek Matjaž5Blanco Federico C.6Bigi Fabiana7Institute of Agrobiotechnology and Molecular Biology (IABIMO), INTA-CONICETHurlingham, ArgentinaInstitute of Agrobiotechnology and Molecular Biology (IABIMO), INTA-CONICETHurlingham, ArgentinaInstitute of Agrobiotechnology and Molecular Biology (IABIMO), INTA-CONICETHurlingham, ArgentinaInstitute of Agrobiotechnology and Molecular Biology (IABIMO), INTA-CONICETHurlingham, ArgentinaInstitute for Microbiology and Parasitology, Veterinary Faculty, University of Ljubljana, SI-1000Ljubljana, SloveniaInstitute for Microbiology and Parasitology, Veterinary Faculty, University of Ljubljana, SI-1000Ljubljana, SloveniaInstitute of Agrobiotechnology and Molecular Biology (IABIMO), INTA-CONICETHurlingham, ArgentinaInstitute of Agrobiotechnology and Molecular Biology (IABIMO), INTA-CONICETHurlingham, ArgentinaMycobacterium bovis and Mycobacterium avium subsp. paratuberculosis, respectively the causative agents of bovine tuberculosis (bTB) and bovine paratuberculosis (PTB), share a high number of antigenic proteins. This characteristics makes the differential diagnosis of the diseases difficult. The interferon gamma (IFN-γ), C-X-C motif chemokine ligand 10 (CXCL10), matrix metallopeptidase 9 (MMP9), interleukin 22 (IL-22) and thrombospondin 1 (THBS1) bovine genes have already been shown to be accurate transcriptional biomarkers of bTB. In order to improve the diagnosis of bTB and PTB, in the present study we evaluated the risk of false positivity of these bTB biomarkers in cattle with PTB.https://doi.org/10.2478/jvetres-2023-0007biomarkersbovine tuberculosisbovine paratuberculosis |
| spellingShingle | Klepp Laura I. Colombatti María A. Moyano Roberto D. Romano María I. Malovrh Tadej Ocepek Matjaž Blanco Federico C. Bigi Fabiana Assessment of tuberculosis biomarkers in paratuberculosis-infected cattle Journal of Veterinary Research biomarkers bovine tuberculosis bovine paratuberculosis |
| title | Assessment of tuberculosis biomarkers in paratuberculosis-infected cattle |
| title_full | Assessment of tuberculosis biomarkers in paratuberculosis-infected cattle |
| title_fullStr | Assessment of tuberculosis biomarkers in paratuberculosis-infected cattle |
| title_full_unstemmed | Assessment of tuberculosis biomarkers in paratuberculosis-infected cattle |
| title_short | Assessment of tuberculosis biomarkers in paratuberculosis-infected cattle |
| title_sort | assessment of tuberculosis biomarkers in paratuberculosis infected cattle |
| topic | biomarkers bovine tuberculosis bovine paratuberculosis |
| url | https://doi.org/10.2478/jvetres-2023-0007 |
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