The preferential accumulation of cadmium ions among various tissues in mice
Cadmium (Cd) is hazardous to human health because of its toxicity and long half-life of clearance. Many studies have explored the relationship between chronic Cd exposure and different human diseases. However, most of the studies limited the study targets of Cd toxicity to two or three organ systems...
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Elsevier
2022-01-01
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| Series: | Toxicology Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214750022000026 |
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| author | Yu-Ting Tai Shing-Hsien Chou Chia-Yun Cheng Chien-Te Ho Hung-Chen Lin Shih-Ming Jung Pao-Hsien Chu Fu-Hsiang Ko |
| author_facet | Yu-Ting Tai Shing-Hsien Chou Chia-Yun Cheng Chien-Te Ho Hung-Chen Lin Shih-Ming Jung Pao-Hsien Chu Fu-Hsiang Ko |
| author_sort | Yu-Ting Tai |
| collection | DOAJ |
| description | Cadmium (Cd) is hazardous to human health because of its toxicity and long half-life of clearance. Many studies have explored the relationship between chronic Cd exposure and different human diseases. However, most of the studies limited the study targets of Cd toxicity to two or three organ systems. The goal of this study was to establish a mouse model of Cd accumulation in most organ systems and to particularly investigate the potential toxic effects of Cd to the cardiovascular system. Mice were divided into three groups: the control group, Cd-100 group, and Cd-200 group. In the control group, Cd was detected in the kidney, lung, liver, heart and urine but was undetectable in the aorta, intestine, thigh bone, spinal bone and serum. Upon chronic exposure in the Cd-100 and Cd-200 groups, Cd accumulated in all tissues, with a dramatic increase in concentration. We confirmed that Cd could accumulate significantly in the heart and aorta upon chronic exposure. This finding might help to explain the potential toxic effects of Cd on these organs. In addition, the calcium concentration in the bones and kidney declined when the exposure to Cd increased. This finding aligned with the negative effects of Cd on bony mineralization and the potential direct toxic effects of Cd on bones. The impacts of Cd on the cardiovascular system were explored. Histologically, chronic Cd exposure led to myocytes hypertrophy and myocardial architecture disarray in the Cd-100 group compared to those in the control group. Our research confirms that Cd can accumulate in all of the organs studied upon chronic exposure, and suggests that the toxicity of Cd accumulation may play important roles in mediating the pathophysiologic effects in these target organs, especially the bone and heart. |
| first_indexed | 2024-04-13T05:29:14Z |
| format | Article |
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| issn | 2214-7500 |
| language | English |
| last_indexed | 2024-04-13T05:29:14Z |
| publishDate | 2022-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Toxicology Reports |
| spelling | doaj.art-41df35fae9cb49c695817c626632f05d2022-12-22T03:00:30ZengElsevierToxicology Reports2214-75002022-01-019111119The preferential accumulation of cadmium ions among various tissues in miceYu-Ting Tai0Shing-Hsien Chou1Chia-Yun Cheng2Chien-Te Ho3Hung-Chen Lin4Shih-Ming Jung5Pao-Hsien Chu6Fu-Hsiang Ko7Department of Materials Science and Engineering, National Yang Ming Chiao Tung University, Hsinchu, 300, TaiwanDivision of Cardiology, Chang Gung Memorial Hospital, Chang Gung University, College of Medicine, Taipei, Taiwan; Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taipei, TaiwanDepartment of Materials Science and Engineering, National Yang Ming Chiao Tung University, Hsinchu, 300, TaiwanDivision of Cardiology, Chang Gung Memorial Hospital, Chang Gung University, College of Medicine, Taipei, TaiwanDivision of Cardiology, Chang Gung Memorial Hospital, Chang Gung University, College of Medicine, Taipei, TaiwanDepartment of Pathology, Ophthalmology, Chang Gung Memorial Hospital, Chang Gung University, College of Medicine, Taipei, TaiwanDivision of Cardiology, Chang Gung Memorial Hospital, Chang Gung University, College of Medicine, Taipei, Taiwan; Corresponding authors.Department of Materials Science and Engineering, National Yang Ming Chiao Tung University, Hsinchu, 300, Taiwan; Corresponding authors.Cadmium (Cd) is hazardous to human health because of its toxicity and long half-life of clearance. Many studies have explored the relationship between chronic Cd exposure and different human diseases. However, most of the studies limited the study targets of Cd toxicity to two or three organ systems. The goal of this study was to establish a mouse model of Cd accumulation in most organ systems and to particularly investigate the potential toxic effects of Cd to the cardiovascular system. Mice were divided into three groups: the control group, Cd-100 group, and Cd-200 group. In the control group, Cd was detected in the kidney, lung, liver, heart and urine but was undetectable in the aorta, intestine, thigh bone, spinal bone and serum. Upon chronic exposure in the Cd-100 and Cd-200 groups, Cd accumulated in all tissues, with a dramatic increase in concentration. We confirmed that Cd could accumulate significantly in the heart and aorta upon chronic exposure. This finding might help to explain the potential toxic effects of Cd on these organs. In addition, the calcium concentration in the bones and kidney declined when the exposure to Cd increased. This finding aligned with the negative effects of Cd on bony mineralization and the potential direct toxic effects of Cd on bones. The impacts of Cd on the cardiovascular system were explored. Histologically, chronic Cd exposure led to myocytes hypertrophy and myocardial architecture disarray in the Cd-100 group compared to those in the control group. Our research confirms that Cd can accumulate in all of the organs studied upon chronic exposure, and suggests that the toxicity of Cd accumulation may play important roles in mediating the pathophysiologic effects in these target organs, especially the bone and heart.http://www.sciencedirect.com/science/article/pii/S2214750022000026CadmiumICP-MSMiceCardiovascular diseaseHeart |
| spellingShingle | Yu-Ting Tai Shing-Hsien Chou Chia-Yun Cheng Chien-Te Ho Hung-Chen Lin Shih-Ming Jung Pao-Hsien Chu Fu-Hsiang Ko The preferential accumulation of cadmium ions among various tissues in mice Toxicology Reports Cadmium ICP-MS Mice Cardiovascular disease Heart |
| title | The preferential accumulation of cadmium ions among various tissues in mice |
| title_full | The preferential accumulation of cadmium ions among various tissues in mice |
| title_fullStr | The preferential accumulation of cadmium ions among various tissues in mice |
| title_full_unstemmed | The preferential accumulation of cadmium ions among various tissues in mice |
| title_short | The preferential accumulation of cadmium ions among various tissues in mice |
| title_sort | preferential accumulation of cadmium ions among various tissues in mice |
| topic | Cadmium ICP-MS Mice Cardiovascular disease Heart |
| url | http://www.sciencedirect.com/science/article/pii/S2214750022000026 |
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