The expression of vascular endothelial growth factor-C correlates with lymphatic microvessel density and lymph node metastasis in prostate carcinoma: An immunohistochemical study
Aim: To evaluate the expression of two different lymphatic vascular density (LVD) markers (D2-40 and LYVE-1) and a lymphangiogenic cytokine (Vascular Endothelial Growth Factor-C, [VEGF-C]) in prostate carcinoma and to investigate their relationship with the lymph node status. Settings and Design: A...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2014-01-01
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| Series: | Urology Annals |
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| Online Access: | http://www.urologyannals.com/article.asp?issn=0974-7796;year=2014;volume=6;issue=3;spage=224;epage=230;aulast=Kostis |
| _version_ | 1819033495380426752 |
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| author | Gyftopoulos Kostis Lilis Ioannis Kourea Helen Papadaki Helen |
| author_facet | Gyftopoulos Kostis Lilis Ioannis Kourea Helen Papadaki Helen |
| author_sort | Gyftopoulos Kostis |
| collection | DOAJ |
| description | Aim: To evaluate the expression of two different lymphatic vascular density (LVD) markers (D2-40 and LYVE-1) and a lymphangiogenic cytokine (Vascular Endothelial Growth Factor-C, [VEGF-C]) in prostate carcinoma and to investigate their relationship with the lymph node status.
Settings and Design: Archival material study of 92 non-consecutive radical prostatectomy specimens.
Materials and Methods: The mean LVD was assessed immunohistochemically in 24 prostate carcinoma specimens from patients with clinically localized disease, who were found to have nodal metastasis (pN1), and was compared with 68 pN0 cases. Furthermore, the mean LVD, VEGF-C expression, and lymphatic invasion were examined in relation to lymph node involvement.
Results: Peritumoral (but not intratumoral) mean LVD assessed by D2-40 was higher in pN1 tumors (P = 0.015). LYVE-1 expression was limited and not associated with lymph node status. The VEGF-C expression was higher in the N1 cases and also correlated with the increased mean LVD in both the peri- and intratumoral compartments. Lymphatic invasion was strongly associated with nodal metastasis and higher VEGF-C expression.
Conclusions: Our results indicate that increased peritumoral (but not intratumoral) LVD in the tumor specimen is associated with lymph node metastasis. Increased expression of VEGF-C is associated with higher LVD (in both intratumoral and peritumoral compartments) and with positive lymph node status, indicating a possible dual role in both lymphangiogenesis and lymphatic vessel invasion. |
| first_indexed | 2024-12-21T07:18:45Z |
| format | Article |
| id | doaj.art-41dfa55502a54bbea62657cd4c4b8de5 |
| institution | Directory Open Access Journal |
| issn | 0974-7796 0974-7834 |
| language | English |
| last_indexed | 2024-12-21T07:18:45Z |
| publishDate | 2014-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Urology Annals |
| spelling | doaj.art-41dfa55502a54bbea62657cd4c4b8de52022-12-21T19:11:49ZengWolters Kluwer Medknow PublicationsUrology Annals0974-77960974-78342014-01-016322423010.4103/0974-7796.134275The expression of vascular endothelial growth factor-C correlates with lymphatic microvessel density and lymph node metastasis in prostate carcinoma: An immunohistochemical studyGyftopoulos KostisLilis IoannisKourea HelenPapadaki HelenAim: To evaluate the expression of two different lymphatic vascular density (LVD) markers (D2-40 and LYVE-1) and a lymphangiogenic cytokine (Vascular Endothelial Growth Factor-C, [VEGF-C]) in prostate carcinoma and to investigate their relationship with the lymph node status. Settings and Design: Archival material study of 92 non-consecutive radical prostatectomy specimens. Materials and Methods: The mean LVD was assessed immunohistochemically in 24 prostate carcinoma specimens from patients with clinically localized disease, who were found to have nodal metastasis (pN1), and was compared with 68 pN0 cases. Furthermore, the mean LVD, VEGF-C expression, and lymphatic invasion were examined in relation to lymph node involvement. Results: Peritumoral (but not intratumoral) mean LVD assessed by D2-40 was higher in pN1 tumors (P = 0.015). LYVE-1 expression was limited and not associated with lymph node status. The VEGF-C expression was higher in the N1 cases and also correlated with the increased mean LVD in both the peri- and intratumoral compartments. Lymphatic invasion was strongly associated with nodal metastasis and higher VEGF-C expression. Conclusions: Our results indicate that increased peritumoral (but not intratumoral) LVD in the tumor specimen is associated with lymph node metastasis. Increased expression of VEGF-C is associated with higher LVD (in both intratumoral and peritumoral compartments) and with positive lymph node status, indicating a possible dual role in both lymphangiogenesis and lymphatic vessel invasion.http://www.urologyannals.com/article.asp?issn=0974-7796;year=2014;volume=6;issue=3;spage=224;epage=230;aulast=KostisImmunohistochemistrylymphangiogenesisprostate adenocarcinomavascular endothelial growth factor-Cvessel density |
| spellingShingle | Gyftopoulos Kostis Lilis Ioannis Kourea Helen Papadaki Helen The expression of vascular endothelial growth factor-C correlates with lymphatic microvessel density and lymph node metastasis in prostate carcinoma: An immunohistochemical study Urology Annals Immunohistochemistry lymphangiogenesis prostate adenocarcinoma vascular endothelial growth factor-C vessel density |
| title | The expression of vascular endothelial growth factor-C correlates with lymphatic microvessel density and lymph node metastasis in prostate carcinoma: An immunohistochemical study |
| title_full | The expression of vascular endothelial growth factor-C correlates with lymphatic microvessel density and lymph node metastasis in prostate carcinoma: An immunohistochemical study |
| title_fullStr | The expression of vascular endothelial growth factor-C correlates with lymphatic microvessel density and lymph node metastasis in prostate carcinoma: An immunohistochemical study |
| title_full_unstemmed | The expression of vascular endothelial growth factor-C correlates with lymphatic microvessel density and lymph node metastasis in prostate carcinoma: An immunohistochemical study |
| title_short | The expression of vascular endothelial growth factor-C correlates with lymphatic microvessel density and lymph node metastasis in prostate carcinoma: An immunohistochemical study |
| title_sort | expression of vascular endothelial growth factor c correlates with lymphatic microvessel density and lymph node metastasis in prostate carcinoma an immunohistochemical study |
| topic | Immunohistochemistry lymphangiogenesis prostate adenocarcinoma vascular endothelial growth factor-C vessel density |
| url | http://www.urologyannals.com/article.asp?issn=0974-7796;year=2014;volume=6;issue=3;spage=224;epage=230;aulast=Kostis |
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