Clinical Implications of Primary Cilia in Skin Cancer
Abstract The primary cilium is a cell surface organelle that is an important component of cellular biology. While it was once believed to be a vestigial structure without biologic function, it is now known to have essential roles in critical cellular signaling pathways such as Hedgehog (HH) and Wnt....
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Adis, Springer Healthcare
2020-01-01
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| Series: | Dermatology and Therapy |
| Subjects: | |
| Online Access: | https://doi.org/10.1007/s13555-020-00355-1 |
| _version_ | 1797259489072644096 |
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| author | Abrar Choudhury Neil M. Neumann David R. Raleigh Ursula E. Lang |
| author_facet | Abrar Choudhury Neil M. Neumann David R. Raleigh Ursula E. Lang |
| author_sort | Abrar Choudhury |
| collection | DOAJ |
| description | Abstract The primary cilium is a cell surface organelle that is an important component of cellular biology. While it was once believed to be a vestigial structure without biologic function, it is now known to have essential roles in critical cellular signaling pathways such as Hedgehog (HH) and Wnt. The HH and Wnt pathways are involved in pathogenesis of basal cell carcinoma and melanoma, respectively, and this knowledge is now beginning to inform therapeutic and diagnostic options for patients. The purpose of this review is to familiarize clinicians with primary cilia biology and how this complex cellular organelle has started to translate into clinical care. |
| first_indexed | 2024-04-24T23:10:14Z |
| format | Article |
| id | doaj.art-41e05c74cdb7419689fd6bb063711a71 |
| institution | Directory Open Access Journal |
| issn | 2193-8210 2190-9172 |
| language | English |
| last_indexed | 2024-04-24T23:10:14Z |
| publishDate | 2020-01-01 |
| publisher | Adis, Springer Healthcare |
| record_format | Article |
| series | Dermatology and Therapy |
| spelling | doaj.art-41e05c74cdb7419689fd6bb063711a712024-03-17T12:16:00ZengAdis, Springer HealthcareDermatology and Therapy2193-82102190-91722020-01-0110223324810.1007/s13555-020-00355-1Clinical Implications of Primary Cilia in Skin CancerAbrar Choudhury0Neil M. Neumann1David R. Raleigh2Ursula E. Lang3Department of Neurological Surgery, University of CaliforniaDepartment of Pathology, Dermatopathology Service, University of CaliforniaDepartment of Neurological Surgery, University of CaliforniaDepartment of Pathology, Dermatopathology Service, University of CaliforniaAbstract The primary cilium is a cell surface organelle that is an important component of cellular biology. While it was once believed to be a vestigial structure without biologic function, it is now known to have essential roles in critical cellular signaling pathways such as Hedgehog (HH) and Wnt. The HH and Wnt pathways are involved in pathogenesis of basal cell carcinoma and melanoma, respectively, and this knowledge is now beginning to inform therapeutic and diagnostic options for patients. The purpose of this review is to familiarize clinicians with primary cilia biology and how this complex cellular organelle has started to translate into clinical care.https://doi.org/10.1007/s13555-020-00355-1Basal cell carcinomaDiagnostic toolHedgehogMelanomaPrimary ciliaSonidegib |
| spellingShingle | Abrar Choudhury Neil M. Neumann David R. Raleigh Ursula E. Lang Clinical Implications of Primary Cilia in Skin Cancer Dermatology and Therapy Basal cell carcinoma Diagnostic tool Hedgehog Melanoma Primary cilia Sonidegib |
| title | Clinical Implications of Primary Cilia in Skin Cancer |
| title_full | Clinical Implications of Primary Cilia in Skin Cancer |
| title_fullStr | Clinical Implications of Primary Cilia in Skin Cancer |
| title_full_unstemmed | Clinical Implications of Primary Cilia in Skin Cancer |
| title_short | Clinical Implications of Primary Cilia in Skin Cancer |
| title_sort | clinical implications of primary cilia in skin cancer |
| topic | Basal cell carcinoma Diagnostic tool Hedgehog Melanoma Primary cilia Sonidegib |
| url | https://doi.org/10.1007/s13555-020-00355-1 |
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