Neuroimmune Interactions in Fetal Alcohol Spectrum Disorders: Potential Therapeutic Targets and Intervention Strategies

Neuroimmune Interactions in Fetal Alcohol Spectrum Disorders: Potential Therapeutic Targets and Intervention Strategies

Fetal alcohol spectrum disorders (FASD) are a set of abnormalities caused by prenatal exposure to ethanol and are characterized by developmental defects in the brain that lead to various overt and non-overt physiological abnormalities. Growing evidence suggests that in utero alcohol exposure induces...

Full description

Bibliographic Details
Main Authors:	Sayani Mukherjee, Prashant Tarale, Dipak K. Sarkar
Format:	Article
Language:	English
Published:	MDPI AG 2023-09-01
Series:	Cells
Subjects:	prenatal ethanol exposure microglia neuroinflammation extracellular vesicles neuronal cell death
Online Access:	https://www.mdpi.com/2073-4409/12/18/2323

Similar Items

TLR4 participates in the transmission of ethanol-induced neuroinflammation via astrocyte-derived extracellular vesicles
by: Francesc Ibáñez, et al.
Published: (2019-07-01)

Bidirectional Microglia–Neuron Communication in Health and Disease
by: Zsuzsanna Szepesi, et al.
Published: (2018-09-01)

TLR4 response mediates ethanol-induced neurodevelopment alterations in a model of fetal alcohol spectrum disorders
by: María Pascual, et al.
Published: (2017-07-01)

A comparison of the different animal models of Fetal Alcohol Spectrum Disorders and their use in studying complex behaviors.
by: Anna R Patten, et al.
Published: (2014-09-01)

Inflammation leads to distinct populations of extracellular vesicles from microglia
by: Yiyi Yang, et al.
Published: (2018-05-01)

Neuroimmune Activation and Microglia Reactivity in Female Rats Following Alcohol Dependence
by: Jennifer K. Melbourne, et al.
Published: (2024-01-01)

TNF Production and Release from Microglia via Extracellular Vesicles: Impact on Brain Functions
by: Stefano Raffaele, et al.
Published: (2020-09-01)

An overview of current advances in perinatal alcohol exposure and pathogenesis of fetal alcohol spectrum disorders
by: Xingdong Zeng, et al.
Published: (2024-04-01)

DICAM in the Extracellular Vesicles from Astrocytes Attenuates Microglia Activation and Neuroinflammation
by: Jin Han, et al.
Published: (2022-09-01)

Editorial: The role of exosomes in neuroinflammation and neurodegeneration
by: Yi Wang, et al.
Published: (2022-12-01)

Dynamics of Microglia Activation in the Ischemic Brain: Implications for Myelin Repair and Functional Recovery
by: Stefano Raffaele, et al.
Published: (2022-07-01)

Neural crest cells and fetal alcohol spectrum disorders: Mechanisms and potential targets for prevention
by: Shao-yu Chen, et al.
Published: (2023-08-01)

What the Spectrum of Microglial Functions Can Teach us About Fetal Alcohol Spectrum Disorder
by: Elissa L. Wong, et al.
Published: (2017-06-01)

Extracellular Vesicles miRNA Cargo for Microglia Polarization in Traumatic Brain Injury
by: Maria Antonietta Panaro, et al.
Published: (2020-06-01)

Neuron-Derived Extracellular Vesicles Modulate Microglia Activation and Function
by: Hui Peng, et al.
Published: (2021-09-01)

Toxic and Teratogenic Effects of Prenatal Alcohol Exposure on Fetal Development, Adolescence, and Adulthood
by: Dae D. Chung, et al.
Published: (2021-08-01)

Peripheral and central macrophages in obesity
by: Sayani Mukherjee, et al.
Published: (2023-08-01)

Dose-related shifts in proteome and function of extracellular vesicles secreted by fetal neural stem cells following chronic alcohol exposure
by: Dae D. Chung, et al.
Published: (2022-11-01)

High resolution imaging and analysis of extracellular vesicles using mass spectral imaging and machine learning
by: Sarah Elizabeth Bamford, et al.
Published: (2023-09-01)

Small Extracellular Vesicles of M1-BV2 Microglia Induce Neuronal PC12 Cells Apoptosis via the Competing Endogenous Mechanism of CircRNAs
by: Sheng Gao, et al.
Published: (2022-09-01)

Sex differences in the transcriptome of extracellular vesicles secreted by fetal neural stem cells and effects of chronic alcohol exposure
by: Dae D. Chung, et al.
Published: (2023-04-01)

Common developmental trajectories and clinical identification of children with fetal alcohol spectrum disorders: A synthesis of the literature
by: Douglas Waite, et al.
Published: (2023-04-01)

Shedding of Microvesicles from Microglia Contributes to the Effects Induced by Metabotropic Glutamate Receptor 5 Activation on Neuronal Death
by: Martina Beneventano, et al.
Published: (2017-11-01)

Inhibition of extracellular vesicle pathway using neutral sphingomyelinase inhibitors as a neuroprotective treatment for brain injury
by: Asit Kumar, et al.
Published: (2021-01-01)

Plasma derived extracellular vesicle biomarkers of microglia activation in an experimental stroke model
by: A. D. Roseborough, et al.
Published: (2023-01-01)

Systematic Review on Tumor Microenvironment in Glial Neoplasm: From Understanding Pathogenesis to Future Therapeutic Perspectives
by: Andrea Bianconi, et al.
Published: (2022-04-01)

Factors predicting general health concerns and atypical behaviours in children with prenatal alcohol exposure and other adverse exposures
by: Sarah J. MacEachern, et al.
Published: (2023-05-01)

Thirty Risk Factors for Alzheimer’s Disease Unified by a Common Neuroimmune–Neuroinflammation Mechanism
by: Donald F. Weaver
Published: (2023-12-01)

Pathophysiology and Neuroimmune Interactions Underlying Parkinson’s Disease and Traumatic Brain Injury
by: Alyssa Lillian, et al.
Published: (2023-04-01)

Genetic Influences on Fetal Alcohol Spectrum Disorder
by: Danielle Sambo, et al.
Published: (2023-01-01)

Mesenchymal-derived extracellular vesicles enhance microglia-mediated synapse remodeling after cortical injury in aging Rhesus monkeys
by: Yuxin Zhou, et al.
Published: (2023-09-01)

Ethanol Induces Extracellular Vesicle Secretion by Altering Lipid Metabolism through the Mitochondria-Associated ER Membranes and Sphingomyelinases
by: Francesc Ibáñez, et al.
Published: (2021-08-01)

Microglia and Stem Cells for Ischemic Stroke Treatment—Mechanisms, Current Status, and Therapeutic Challenges
by: Aleksandra Markowska, et al.
Published: (2023-10-01)

Moderate Maternal Alcohol Exposure on Gestational Day 12 Impacts Anxiety-Like Behavior in Offspring
by: Siara K. Rouzer, et al.
Published: (2017-09-01)

Extracellular Vesicles, Influential Players of Intercellular Communication within Adult Neurogenic Niches
by: Morris Losurdo, et al.
Published: (2020-11-01)

Co-cultures of Glioma Stem Cells and Primary Neurons, Astrocytes, Microglia, and Endothelial Cells for Investigation of Intercellular Communication in the Brain
by: Zhiyun Wei, et al.
Published: (2019-04-01)

Fractalkine is a "find-me" signal released by neurons undergoing ethanol-induced apoptosis
by: Jennifer D Sokolowski, et al.
Published: (2014-11-01)

Extracellular Vesicles From Hyperammonemic Rats Induce Neuroinflammation in Cerebellum of Normal Rats: Role of Increased TNFα Content
by: Paula Izquierdo-Altarejos, et al.
Published: (2022-07-01)

Screening for fetal alcohol spectrum disorder in infants and young children
by: Lauren Fleming, et al.
Published: (2023-07-01)

Sleep Disturbance Alters Cocaine-Induced Locomotor Activity: Involvement of Striatal Neuroimmune and Dopamine Signaling
by: Soheil Kazemi Roodsari, et al.
Published: (2022-05-01)