Evidence of RedOX Imbalance during Zika Virus Infection Promoting the Formation of Disulfide-Bond-Dependent Oligomers of the Envelope Protein

Evidence of RedOX Imbalance during Zika Virus Infection Promoting the Formation of Disulfide-Bond-Dependent Oligomers of the Envelope Protein

Flaviviruses replicate in membrane factories associated with the endoplasmic reticulum (ER). Significant levels of flavivirus viral protein accumulation contribute to ER stress. As a consequence, the host cell exhibits an Unfolded Protein Response (UPR), subsequently stimulating appropriate cellular...

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Bibliographic Details
Main Authors: Grégorie Lebeau, Jonathan Turpin, Etienne Frumence, Daed El Safadi, Wissal Harrabi, Philippe Desprès, Pascale Krejbich-Trotot, Wildriss Viranaïcken
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Viruses
Subjects:
Zika virus
unfolded protein response
ER stress
oligomer
disulfide bond
amyloid aggregates
Online Access:https://www.mdpi.com/1999-4915/14/6/1131

Internet

https://www.mdpi.com/1999-4915/14/6/1131

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