Relationship between vaginal group B streptococcus colonization in the early stage of pregnancy and preterm birth: a retrospective cohort study
Abstract Background Although infection and inflammation within the genital tract during pregnancy is considered a major risk factor for spontaneous preterm birth (PTB), there are few studies on association between vaginal microorganisms in the early stage of pregnancy and PTB. The aim of this study...
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| Language: | English |
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BMC
2021-02-01
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| Series: | BMC Pregnancy and Childbirth |
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| Online Access: | https://doi.org/10.1186/s12884-021-03624-9 |
| _version_ | 1818953328180068352 |
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| author | Sho Tano Takuji Ueno Michinori Mayama Takuma Yamada Takehiko Takeda Kaname Uno Masato Yoshihara Mayu Ukai Teppei Suzuki Yasuyuki Kishigami Hidenori Oguchi |
| author_facet | Sho Tano Takuji Ueno Michinori Mayama Takuma Yamada Takehiko Takeda Kaname Uno Masato Yoshihara Mayu Ukai Teppei Suzuki Yasuyuki Kishigami Hidenori Oguchi |
| author_sort | Sho Tano |
| collection | DOAJ |
| description | Abstract Background Although infection and inflammation within the genital tract during pregnancy is considered a major risk factor for spontaneous preterm birth (PTB), there are few studies on association between vaginal microorganisms in the early stage of pregnancy and PTB. The aim of this study was to investigate relationship between vaginal Group B streptococcus (GBS) colonization, a leading cause of infection during pregnancy, in the early stage of pregnancy and PTB. Methods This single-center, retrospective cohort study utilized data from 2009 to 2017 obtained at TOYOTA Memorial Hospital. Women with singleton pregnancies who underwent vaginal culture around 14 weeks of gestation during their routine prenatal check-up were included. Vaginal sampling for Gram staining and culture was performed regardless of symptoms. GBS colonization was defined as positive for GBS latex agglutination assay. Statistical analysis was performed to determine the factors associated with PTB. Results Overall 1079 singleton pregnancies were included. GBS (5.7%) and Candida albicans (5.5%) were the most frequently observed microorganisms. The incidence of PTB (before 34 and before 37 weeks of gestation) were significantly higher in the GBS-positive group than in the GBS-negative group (6.6% vs 0.5%, p = 0.001 and 9.8% vs 4.3%, p = 0.047). Our multivariable logistic regression analysis revealed that GBS colonization was a factor associated with PTB before 34 and before 37 weeks of gestation (Odds ratio [OR] 15.17; 95% confidence interval [CI] 3.73–61.74), and OR 2.42; 95%CI 1.01–5.91, respectively). Conclusions The present study found that vaginal GBS colonization in the early stage of pregnancy was associated with PTB. Our study indicates that patients at a high risk for PTB can be extracted by a simple method using conventional culture method. |
| first_indexed | 2024-12-20T10:04:31Z |
| format | Article |
| id | doaj.art-41e28911604943bf8c27e7635b90c2da |
| institution | Directory Open Access Journal |
| issn | 1471-2393 |
| language | English |
| last_indexed | 2024-12-20T10:04:31Z |
| publishDate | 2021-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pregnancy and Childbirth |
| spelling | doaj.art-41e28911604943bf8c27e7635b90c2da2022-12-21T19:44:15ZengBMCBMC Pregnancy and Childbirth1471-23932021-02-012111910.1186/s12884-021-03624-9Relationship between vaginal group B streptococcus colonization in the early stage of pregnancy and preterm birth: a retrospective cohort studySho Tano0Takuji Ueno1Michinori Mayama2Takuma Yamada3Takehiko Takeda4Kaname Uno5Masato Yoshihara6Mayu Ukai7Teppei Suzuki8Yasuyuki Kishigami9Hidenori Oguchi10Department of Obstetrics, Perinatal Medical Center, TOYOTA Memorial HospitalDepartment of Obstetrics, Perinatal Medical Center, TOYOTA Memorial HospitalDepartment of Obstetrics, Perinatal Medical Center, TOYOTA Memorial HospitalDepartment of Obstetrics, Perinatal Medical Center, TOYOTA Memorial HospitalDepartment of Obstetrics, Perinatal Medical Center, TOYOTA Memorial HospitalDepartment of Obstetrics, Perinatal Medical Center, TOYOTA Memorial HospitalDepartment of Obstetrics and Gynecology, Nagoya University Graduate School of MedicineDepartment of Obstetrics, Perinatal Medical Center, TOYOTA Memorial HospitalDepartment of Obstetrics, Perinatal Medical Center, TOYOTA Memorial HospitalDepartment of Obstetrics, Perinatal Medical Center, TOYOTA Memorial HospitalDepartment of Obstetrics, Perinatal Medical Center, TOYOTA Memorial HospitalAbstract Background Although infection and inflammation within the genital tract during pregnancy is considered a major risk factor for spontaneous preterm birth (PTB), there are few studies on association between vaginal microorganisms in the early stage of pregnancy and PTB. The aim of this study was to investigate relationship between vaginal Group B streptococcus (GBS) colonization, a leading cause of infection during pregnancy, in the early stage of pregnancy and PTB. Methods This single-center, retrospective cohort study utilized data from 2009 to 2017 obtained at TOYOTA Memorial Hospital. Women with singleton pregnancies who underwent vaginal culture around 14 weeks of gestation during their routine prenatal check-up were included. Vaginal sampling for Gram staining and culture was performed regardless of symptoms. GBS colonization was defined as positive for GBS latex agglutination assay. Statistical analysis was performed to determine the factors associated with PTB. Results Overall 1079 singleton pregnancies were included. GBS (5.7%) and Candida albicans (5.5%) were the most frequently observed microorganisms. The incidence of PTB (before 34 and before 37 weeks of gestation) were significantly higher in the GBS-positive group than in the GBS-negative group (6.6% vs 0.5%, p = 0.001 and 9.8% vs 4.3%, p = 0.047). Our multivariable logistic regression analysis revealed that GBS colonization was a factor associated with PTB before 34 and before 37 weeks of gestation (Odds ratio [OR] 15.17; 95% confidence interval [CI] 3.73–61.74), and OR 2.42; 95%CI 1.01–5.91, respectively). Conclusions The present study found that vaginal GBS colonization in the early stage of pregnancy was associated with PTB. Our study indicates that patients at a high risk for PTB can be extracted by a simple method using conventional culture method.https://doi.org/10.1186/s12884-021-03624-9Preterm birthGroup B StreptococcusVaginal flora |
| spellingShingle | Sho Tano Takuji Ueno Michinori Mayama Takuma Yamada Takehiko Takeda Kaname Uno Masato Yoshihara Mayu Ukai Teppei Suzuki Yasuyuki Kishigami Hidenori Oguchi Relationship between vaginal group B streptococcus colonization in the early stage of pregnancy and preterm birth: a retrospective cohort study BMC Pregnancy and Childbirth Preterm birth Group B Streptococcus Vaginal flora |
| title | Relationship between vaginal group B streptococcus colonization in the early stage of pregnancy and preterm birth: a retrospective cohort study |
| title_full | Relationship between vaginal group B streptococcus colonization in the early stage of pregnancy and preterm birth: a retrospective cohort study |
| title_fullStr | Relationship between vaginal group B streptococcus colonization in the early stage of pregnancy and preterm birth: a retrospective cohort study |
| title_full_unstemmed | Relationship between vaginal group B streptococcus colonization in the early stage of pregnancy and preterm birth: a retrospective cohort study |
| title_short | Relationship between vaginal group B streptococcus colonization in the early stage of pregnancy and preterm birth: a retrospective cohort study |
| title_sort | relationship between vaginal group b streptococcus colonization in the early stage of pregnancy and preterm birth a retrospective cohort study |
| topic | Preterm birth Group B Streptococcus Vaginal flora |
| url | https://doi.org/10.1186/s12884-021-03624-9 |
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