Antidiabetic activity of Chandraprabha vati – A classical Ayurvedic formulation
Background: Chandraprabha vati is a classical Ayurvedic formulation, markedly used for mitigation of Prameha, which correlates in many ways with obesity, metabolic syndrome and diabetes mellitus. Objective: The present study was aimed to investigate effect of Chandraprabha vati in experimentally-ind...
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| Format: | Article |
| Language: | English |
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Elsevier
2016-07-01
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| Series: | Journal of Ayurveda and Integrative Medicine |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0975947616300419 |
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| author | Manish M. Wanjari Sujata Mishra Yadu Nandan Dey Deepti Sharma Sudesh N. Gaidhani Ankush D. Jadhav |
| author_facet | Manish M. Wanjari Sujata Mishra Yadu Nandan Dey Deepti Sharma Sudesh N. Gaidhani Ankush D. Jadhav |
| author_sort | Manish M. Wanjari |
| collection | DOAJ |
| description | Background: Chandraprabha vati is a classical Ayurvedic formulation, markedly used for mitigation of Prameha, which correlates in many ways with obesity, metabolic syndrome and diabetes mellitus.
Objective: The present study was aimed to investigate effect of Chandraprabha vati in experimentally-induced hyperglycemia and lipid profile alterations.
Materials and methods: Antidiabetic effect of Chandraprabha vati was studied in fifty five Wistar rats. Graded doses of Chandraprabha vati (50, 100 and 200 mg/kg) were administered orally for 7 days to normal and alloxan-hyperglycemic rats (65 mg/kg, intravenously), and to glucose loaded normal rats for oral glucose tolerance test (OGTT). Fasting plasma glucose levels were assessed on different time intervals along with plasma cholesterol and triglycerides. Metformin (500 mg/kg, orally) was used as standard drug.
Results: Chandraprabha vati did not cause any significant reduction in plasma glucose levels of normal rats (p > 0.05) but normalized the impaired glucose tolerance at 60 and 120 min (p < 0.05–p < 0.001) in OGTT when compared to vehicle control. In alloxan-hyperglycemic rats, administration of Chandraprabha vati (200 mg/kg) significantly reduced plasma glucose at 3 h, 12 h, 3rd day and 7th day (p < 0.01–p < 0.001) along with reduction in cholesterol and triglycerides levels (p < 0.01–p < 0.001) when compared to diabetic control group. The effects were comparable with metformin.
Conclusions: Chandraprabha vati exhibited anti-hyperglycemic effect and attenuated alterations in lipid profile. The results support the use of Chandraprabha vati for correction of Prameha in clinical practice. |
| first_indexed | 2024-12-10T04:46:29Z |
| format | Article |
| id | doaj.art-41e2bf372fab4cfa951552e2cc7bc9c5 |
| institution | Directory Open Access Journal |
| issn | 0975-9476 |
| language | English |
| last_indexed | 2024-12-10T04:46:29Z |
| publishDate | 2016-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Ayurveda and Integrative Medicine |
| spelling | doaj.art-41e2bf372fab4cfa951552e2cc7bc9c52022-12-22T02:01:44ZengElsevierJournal of Ayurveda and Integrative Medicine0975-94762016-07-017314415010.1016/j.jaim.2016.08.010Antidiabetic activity of Chandraprabha vati – A classical Ayurvedic formulationManish M. Wanjari0Sujata Mishra1Yadu Nandan Dey2Deepti Sharma3Sudesh N. Gaidhani4Ankush D. Jadhav5National Research Institute for Ayurveda-Siddha Human Resource Development, Gwalior, 474009, Madhya Pradesh, IndiaSchool of Studies in Biochemistry, Jiwaji University, Gwalior, 474011, Madhya Pradesh, IndiaNational Research Institute for Ayurveda-Siddha Human Resource Development, Gwalior, 474009, Madhya Pradesh, IndiaNational Research Institute for Ayurveda-Siddha Human Resource Development, Gwalior, 474009, Madhya Pradesh, IndiaCentral Council for Research in Ayurvedic Sciences, New Delhi, 110058, IndiaNational Research Institute for Ayurveda-Siddha Human Resource Development, Gwalior, 474009, Madhya Pradesh, IndiaBackground: Chandraprabha vati is a classical Ayurvedic formulation, markedly used for mitigation of Prameha, which correlates in many ways with obesity, metabolic syndrome and diabetes mellitus. Objective: The present study was aimed to investigate effect of Chandraprabha vati in experimentally-induced hyperglycemia and lipid profile alterations. Materials and methods: Antidiabetic effect of Chandraprabha vati was studied in fifty five Wistar rats. Graded doses of Chandraprabha vati (50, 100 and 200 mg/kg) were administered orally for 7 days to normal and alloxan-hyperglycemic rats (65 mg/kg, intravenously), and to glucose loaded normal rats for oral glucose tolerance test (OGTT). Fasting plasma glucose levels were assessed on different time intervals along with plasma cholesterol and triglycerides. Metformin (500 mg/kg, orally) was used as standard drug. Results: Chandraprabha vati did not cause any significant reduction in plasma glucose levels of normal rats (p > 0.05) but normalized the impaired glucose tolerance at 60 and 120 min (p < 0.05–p < 0.001) in OGTT when compared to vehicle control. In alloxan-hyperglycemic rats, administration of Chandraprabha vati (200 mg/kg) significantly reduced plasma glucose at 3 h, 12 h, 3rd day and 7th day (p < 0.01–p < 0.001) along with reduction in cholesterol and triglycerides levels (p < 0.01–p < 0.001) when compared to diabetic control group. The effects were comparable with metformin. Conclusions: Chandraprabha vati exhibited anti-hyperglycemic effect and attenuated alterations in lipid profile. The results support the use of Chandraprabha vati for correction of Prameha in clinical practice.http://www.sciencedirect.com/science/article/pii/S0975947616300419Anti-hyperglycemicGlucose tolerance testPramehaLipid profileMetformin |
| spellingShingle | Manish M. Wanjari Sujata Mishra Yadu Nandan Dey Deepti Sharma Sudesh N. Gaidhani Ankush D. Jadhav Antidiabetic activity of Chandraprabha vati – A classical Ayurvedic formulation Journal of Ayurveda and Integrative Medicine Anti-hyperglycemic Glucose tolerance test Prameha Lipid profile Metformin |
| title | Antidiabetic activity of Chandraprabha vati – A classical Ayurvedic formulation |
| title_full | Antidiabetic activity of Chandraprabha vati – A classical Ayurvedic formulation |
| title_fullStr | Antidiabetic activity of Chandraprabha vati – A classical Ayurvedic formulation |
| title_full_unstemmed | Antidiabetic activity of Chandraprabha vati – A classical Ayurvedic formulation |
| title_short | Antidiabetic activity of Chandraprabha vati – A classical Ayurvedic formulation |
| title_sort | antidiabetic activity of chandraprabha vati a classical ayurvedic formulation |
| topic | Anti-hyperglycemic Glucose tolerance test Prameha Lipid profile Metformin |
| url | http://www.sciencedirect.com/science/article/pii/S0975947616300419 |
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