Histone 4 lysine 20 tri-methylation: a key epigenetic regulator in chromatin structure and disease
Chromatin is a vital and dynamic structure that is carefully regulated to maintain proper cell homeostasis. A great deal of this regulation is dependent on histone proteins which have the ability to be dynamically modified on their tails via various post-translational modifications (PTMs). While mul...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-08-01
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| Series: | Frontiers in Genetics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fgene.2023.1243395/full |
| _version_ | 1797739886182137856 |
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| author | Alejandra Agredo Alejandra Agredo Andrea L. Kasinski Andrea L. Kasinski |
| author_facet | Alejandra Agredo Alejandra Agredo Andrea L. Kasinski Andrea L. Kasinski |
| author_sort | Alejandra Agredo |
| collection | DOAJ |
| description | Chromatin is a vital and dynamic structure that is carefully regulated to maintain proper cell homeostasis. A great deal of this regulation is dependent on histone proteins which have the ability to be dynamically modified on their tails via various post-translational modifications (PTMs). While multiple histone PTMs are studied and often work in concert to facilitate gene expression, here we focus on the tri-methylation of histone H4 on lysine 20 (H4K20me3) and its function in chromatin structure, cell cycle, DNA repair, and development. The recent studies evaluated in this review have shed light on how H4K20me3 is established and regulated by various interacting partners and how H4K20me3 and the proteins that interact with this PTM are involved in various diseases. Through analyzing the current literature on H4K20me3 function and regulation, we aim to summarize this knowledge and highlights gaps that remain in the field. |
| first_indexed | 2024-03-12T14:04:37Z |
| format | Article |
| id | doaj.art-41e3c8188894421a9b267c60f924c102 |
| institution | Directory Open Access Journal |
| issn | 1664-8021 |
| language | English |
| last_indexed | 2024-03-12T14:04:37Z |
| publishDate | 2023-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Genetics |
| spelling | doaj.art-41e3c8188894421a9b267c60f924c1022023-08-21T15:35:43ZengFrontiers Media S.A.Frontiers in Genetics1664-80212023-08-011410.3389/fgene.2023.12433951243395Histone 4 lysine 20 tri-methylation: a key epigenetic regulator in chromatin structure and diseaseAlejandra Agredo0Alejandra Agredo1Andrea L. Kasinski2Andrea L. Kasinski3Department of Biological Sciences, Purdue University, West Lafayette, IN, United StatesPurdue Life Sciences Interdisciplinary Program (PULSe), Purdue University, West Lafayette, IN, United StatesDepartment of Biological Sciences, Purdue University, West Lafayette, IN, United StatesPurdue Institute for Cancer Research, Purdue University, West Lafayette, IN, United StatesChromatin is a vital and dynamic structure that is carefully regulated to maintain proper cell homeostasis. A great deal of this regulation is dependent on histone proteins which have the ability to be dynamically modified on their tails via various post-translational modifications (PTMs). While multiple histone PTMs are studied and often work in concert to facilitate gene expression, here we focus on the tri-methylation of histone H4 on lysine 20 (H4K20me3) and its function in chromatin structure, cell cycle, DNA repair, and development. The recent studies evaluated in this review have shed light on how H4K20me3 is established and regulated by various interacting partners and how H4K20me3 and the proteins that interact with this PTM are involved in various diseases. Through analyzing the current literature on H4K20me3 function and regulation, we aim to summarize this knowledge and highlights gaps that remain in the field.https://www.frontiersin.org/articles/10.3389/fgene.2023.1243395/fullH4K20me3chromatinheterochromatinhistonemethylationdisease |
| spellingShingle | Alejandra Agredo Alejandra Agredo Andrea L. Kasinski Andrea L. Kasinski Histone 4 lysine 20 tri-methylation: a key epigenetic regulator in chromatin structure and disease Frontiers in Genetics H4K20me3 chromatin heterochromatin histone methylation disease |
| title | Histone 4 lysine 20 tri-methylation: a key epigenetic regulator in chromatin structure and disease |
| title_full | Histone 4 lysine 20 tri-methylation: a key epigenetic regulator in chromatin structure and disease |
| title_fullStr | Histone 4 lysine 20 tri-methylation: a key epigenetic regulator in chromatin structure and disease |
| title_full_unstemmed | Histone 4 lysine 20 tri-methylation: a key epigenetic regulator in chromatin structure and disease |
| title_short | Histone 4 lysine 20 tri-methylation: a key epigenetic regulator in chromatin structure and disease |
| title_sort | histone 4 lysine 20 tri methylation a key epigenetic regulator in chromatin structure and disease |
| topic | H4K20me3 chromatin heterochromatin histone methylation disease |
| url | https://www.frontiersin.org/articles/10.3389/fgene.2023.1243395/full |
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