Cue-Induced Brain Activation in Chronic Ketamine-Dependent Subjects, Cigarette Smokers, and Healthy Controls: A Task Functional Magnetic Resonance Imaging Study
BackgroundObservations of drug-related cues may induce craving in drug-dependent patients, prompting compulsive drug-seeking behavior. Sexual dysfunction is common in drug users. The aim of the study was to examine regional brain activation to drug (ketamine, cigarette smoking) associated cues and n...
Main Authors: | , , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2018-03-01
|
Series: | Frontiers in Psychiatry |
Subjects: | |
Online Access: | http://journal.frontiersin.org/article/10.3389/fpsyt.2018.00088/full |
_version_ | 1811274940039561216 |
---|---|
author | Yanhui Liao Yanhui Liao Yanhui Liao Yanhui Liao Yanhui Liao Maritza Johnson Chang Qi Qiuxia Wu An Xie Jianbin Liu Mei Yang Mei Yang Maifang Huang Yan Zhang Tieqiao Liu Wei Hao Jinsong Tang Jinsong Tang Jinsong Tang Jinsong Tang Jinsong Tang |
author_facet | Yanhui Liao Yanhui Liao Yanhui Liao Yanhui Liao Yanhui Liao Maritza Johnson Chang Qi Qiuxia Wu An Xie Jianbin Liu Mei Yang Mei Yang Maifang Huang Yan Zhang Tieqiao Liu Wei Hao Jinsong Tang Jinsong Tang Jinsong Tang Jinsong Tang Jinsong Tang |
author_sort | Yanhui Liao |
collection | DOAJ |
description | BackgroundObservations of drug-related cues may induce craving in drug-dependent patients, prompting compulsive drug-seeking behavior. Sexual dysfunction is common in drug users. The aim of the study was to examine regional brain activation to drug (ketamine, cigarette smoking) associated cues and natural (sexual) rewards.MethodsA sample of 129 [40 ketamine use smokers (KUS), 45 non-ketamine use smokers (NKUS) and 44 non-ketamine use non-smoking healthy controls (HC)] participants underwent functional magnetic resonance imaging (fMRI) while viewing ketamine use related, smoking and sexual films.ResultsWe found that KUS showed significant increased activation in anterior cingulate cortex and precuneus in response to ketamine cues. Ketamine users (KUS) showed lower activation in cerebellum and middle temporal cortex compared with non-ketamine users (NKUS and HC) in response to sexual cues. Smokers (KUS and NKUS) showed higher activation in the right precentral frontal cortex in response to smoking cues. Non-ketamine users (NKUS and HC) showed significantly increased activation of cerebellum and middle temporal cortex while viewing sexual cues.ConclusionThese findings clearly show the engagement of distinct neural circuitry for drug-related stimuli in chronic ketamine users. While smokers (both KUS and NKUS) showed overlapping differences in activation for smoking cues, the former group showed a specific neural response to relevant (i.e., ketamine-related) cues. In particular, the heightened response in anterior cingulate cortex may have important implications for how attentionally salient such cues are in this group. Ketamine users (KUS) showed lower activation in response to sexual cues may partly reflect the neural basis of sexual dysfunction. |
first_indexed | 2024-04-12T23:29:22Z |
format | Article |
id | doaj.art-41e49ef0df4042048fefbee4ebceaf51 |
institution | Directory Open Access Journal |
issn | 1664-0640 |
language | English |
last_indexed | 2024-04-12T23:29:22Z |
publishDate | 2018-03-01 |
publisher | Frontiers Media S.A. |
record_format | Article |
series | Frontiers in Psychiatry |
spelling | doaj.art-41e49ef0df4042048fefbee4ebceaf512022-12-22T03:12:20ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402018-03-01910.3389/fpsyt.2018.00088338224Cue-Induced Brain Activation in Chronic Ketamine-Dependent Subjects, Cigarette Smokers, and Healthy Controls: A Task Functional Magnetic Resonance Imaging StudyYanhui Liao0Yanhui Liao1Yanhui Liao2Yanhui Liao3Yanhui Liao4Maritza Johnson5Chang Qi6Qiuxia Wu7An Xie8Jianbin Liu9Mei Yang10Mei Yang11Maifang Huang12Yan Zhang13Tieqiao Liu14Wei Hao15Jinsong Tang16Jinsong Tang17Jinsong Tang18Jinsong Tang19Jinsong Tang20Department of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, ChinaMental Health Institute, The Second Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center on Mental Disorders, Changsha, ChinaNational Technology Institute on Mental Disorders, Changsha, ChinaHunan Key Laboratory of Psychiatry and Mental Health, Changsha, ChinaDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, CA, United StatesDepartment of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Radiology, The People’s Hospital of Hunan Province, Changsha, ChinaDepartment of Radiology, The People’s Hospital of Hunan Province, Changsha, ChinaDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, CA, United StatesDepartment of Addiction Medicine, Shenzhen Mental Health Center, Shenzhen Kangning Hospital, Shenzhen, ChinaKangda Voluntary Drug Rehabilitation Center, Changsha, ChinaDepartment of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, ChinaMental Health Institute, The Second Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center on Mental Disorders, Changsha, ChinaNational Technology Institute on Mental Disorders, Changsha, ChinaHunan Key Laboratory of Psychiatry and Mental Health, Changsha, ChinaBackgroundObservations of drug-related cues may induce craving in drug-dependent patients, prompting compulsive drug-seeking behavior. Sexual dysfunction is common in drug users. The aim of the study was to examine regional brain activation to drug (ketamine, cigarette smoking) associated cues and natural (sexual) rewards.MethodsA sample of 129 [40 ketamine use smokers (KUS), 45 non-ketamine use smokers (NKUS) and 44 non-ketamine use non-smoking healthy controls (HC)] participants underwent functional magnetic resonance imaging (fMRI) while viewing ketamine use related, smoking and sexual films.ResultsWe found that KUS showed significant increased activation in anterior cingulate cortex and precuneus in response to ketamine cues. Ketamine users (KUS) showed lower activation in cerebellum and middle temporal cortex compared with non-ketamine users (NKUS and HC) in response to sexual cues. Smokers (KUS and NKUS) showed higher activation in the right precentral frontal cortex in response to smoking cues. Non-ketamine users (NKUS and HC) showed significantly increased activation of cerebellum and middle temporal cortex while viewing sexual cues.ConclusionThese findings clearly show the engagement of distinct neural circuitry for drug-related stimuli in chronic ketamine users. While smokers (both KUS and NKUS) showed overlapping differences in activation for smoking cues, the former group showed a specific neural response to relevant (i.e., ketamine-related) cues. In particular, the heightened response in anterior cingulate cortex may have important implications for how attentionally salient such cues are in this group. Ketamine users (KUS) showed lower activation in response to sexual cues may partly reflect the neural basis of sexual dysfunction.http://journal.frontiersin.org/article/10.3389/fpsyt.2018.00088/fullketamine userscigarette smokerscuebrain activationfunctional magnetic resonance imaging |
spellingShingle | Yanhui Liao Yanhui Liao Yanhui Liao Yanhui Liao Yanhui Liao Maritza Johnson Chang Qi Qiuxia Wu An Xie Jianbin Liu Mei Yang Mei Yang Maifang Huang Yan Zhang Tieqiao Liu Wei Hao Jinsong Tang Jinsong Tang Jinsong Tang Jinsong Tang Jinsong Tang Cue-Induced Brain Activation in Chronic Ketamine-Dependent Subjects, Cigarette Smokers, and Healthy Controls: A Task Functional Magnetic Resonance Imaging Study Frontiers in Psychiatry ketamine users cigarette smokers cue brain activation functional magnetic resonance imaging |
title | Cue-Induced Brain Activation in Chronic Ketamine-Dependent Subjects, Cigarette Smokers, and Healthy Controls: A Task Functional Magnetic Resonance Imaging Study |
title_full | Cue-Induced Brain Activation in Chronic Ketamine-Dependent Subjects, Cigarette Smokers, and Healthy Controls: A Task Functional Magnetic Resonance Imaging Study |
title_fullStr | Cue-Induced Brain Activation in Chronic Ketamine-Dependent Subjects, Cigarette Smokers, and Healthy Controls: A Task Functional Magnetic Resonance Imaging Study |
title_full_unstemmed | Cue-Induced Brain Activation in Chronic Ketamine-Dependent Subjects, Cigarette Smokers, and Healthy Controls: A Task Functional Magnetic Resonance Imaging Study |
title_short | Cue-Induced Brain Activation in Chronic Ketamine-Dependent Subjects, Cigarette Smokers, and Healthy Controls: A Task Functional Magnetic Resonance Imaging Study |
title_sort | cue induced brain activation in chronic ketamine dependent subjects cigarette smokers and healthy controls a task functional magnetic resonance imaging study |
topic | ketamine users cigarette smokers cue brain activation functional magnetic resonance imaging |
url | http://journal.frontiersin.org/article/10.3389/fpsyt.2018.00088/full |
work_keys_str_mv | AT yanhuiliao cueinducedbrainactivationinchronicketaminedependentsubjectscigarettesmokersandhealthycontrolsataskfunctionalmagneticresonanceimagingstudy AT yanhuiliao cueinducedbrainactivationinchronicketaminedependentsubjectscigarettesmokersandhealthycontrolsataskfunctionalmagneticresonanceimagingstudy AT yanhuiliao cueinducedbrainactivationinchronicketaminedependentsubjectscigarettesmokersandhealthycontrolsataskfunctionalmagneticresonanceimagingstudy AT yanhuiliao cueinducedbrainactivationinchronicketaminedependentsubjectscigarettesmokersandhealthycontrolsataskfunctionalmagneticresonanceimagingstudy AT yanhuiliao cueinducedbrainactivationinchronicketaminedependentsubjectscigarettesmokersandhealthycontrolsataskfunctionalmagneticresonanceimagingstudy AT maritzajohnson cueinducedbrainactivationinchronicketaminedependentsubjectscigarettesmokersandhealthycontrolsataskfunctionalmagneticresonanceimagingstudy AT changqi cueinducedbrainactivationinchronicketaminedependentsubjectscigarettesmokersandhealthycontrolsataskfunctionalmagneticresonanceimagingstudy AT qiuxiawu cueinducedbrainactivationinchronicketaminedependentsubjectscigarettesmokersandhealthycontrolsataskfunctionalmagneticresonanceimagingstudy AT anxie cueinducedbrainactivationinchronicketaminedependentsubjectscigarettesmokersandhealthycontrolsataskfunctionalmagneticresonanceimagingstudy AT jianbinliu cueinducedbrainactivationinchronicketaminedependentsubjectscigarettesmokersandhealthycontrolsataskfunctionalmagneticresonanceimagingstudy AT meiyang cueinducedbrainactivationinchronicketaminedependentsubjectscigarettesmokersandhealthycontrolsataskfunctionalmagneticresonanceimagingstudy AT meiyang cueinducedbrainactivationinchronicketaminedependentsubjectscigarettesmokersandhealthycontrolsataskfunctionalmagneticresonanceimagingstudy AT maifanghuang cueinducedbrainactivationinchronicketaminedependentsubjectscigarettesmokersandhealthycontrolsataskfunctionalmagneticresonanceimagingstudy AT yanzhang cueinducedbrainactivationinchronicketaminedependentsubjectscigarettesmokersandhealthycontrolsataskfunctionalmagneticresonanceimagingstudy AT tieqiaoliu cueinducedbrainactivationinchronicketaminedependentsubjectscigarettesmokersandhealthycontrolsataskfunctionalmagneticresonanceimagingstudy AT weihao cueinducedbrainactivationinchronicketaminedependentsubjectscigarettesmokersandhealthycontrolsataskfunctionalmagneticresonanceimagingstudy AT jinsongtang cueinducedbrainactivationinchronicketaminedependentsubjectscigarettesmokersandhealthycontrolsataskfunctionalmagneticresonanceimagingstudy AT jinsongtang cueinducedbrainactivationinchronicketaminedependentsubjectscigarettesmokersandhealthycontrolsataskfunctionalmagneticresonanceimagingstudy AT jinsongtang cueinducedbrainactivationinchronicketaminedependentsubjectscigarettesmokersandhealthycontrolsataskfunctionalmagneticresonanceimagingstudy AT jinsongtang cueinducedbrainactivationinchronicketaminedependentsubjectscigarettesmokersandhealthycontrolsataskfunctionalmagneticresonanceimagingstudy AT jinsongtang cueinducedbrainactivationinchronicketaminedependentsubjectscigarettesmokersandhealthycontrolsataskfunctionalmagneticresonanceimagingstudy |