The association between cardiac magnetic resonance-derived aortic stiffness parameters and aortic dilation in young adults with bicuspid aortic valve: With and without coarctation of aorta
Background: Bicuspid aortic valve (BAV) is associated with progressive aortic dilation. Studies in aortopathies have shown a correlation between increased aortic stiffness and aortic dilation. We aimed to evaluate aortic stiffness measures as predictors of progressive aortic dilation by cardiac magn...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-08-01
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| Series: | American Heart Journal Plus |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666602222001112 |
| _version_ | 1811215969186480128 |
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| author | Vasutakarn Chongthammakun Amy Y. Pan Michael G. Earing Abdulla A. Damluji Benjamin H. Goot Joseph R. Cava Jennifer F. Gerardin |
| author_facet | Vasutakarn Chongthammakun Amy Y. Pan Michael G. Earing Abdulla A. Damluji Benjamin H. Goot Joseph R. Cava Jennifer F. Gerardin |
| author_sort | Vasutakarn Chongthammakun |
| collection | DOAJ |
| description | Background: Bicuspid aortic valve (BAV) is associated with progressive aortic dilation. Studies in aortopathies have shown a correlation between increased aortic stiffness and aortic dilation. We aimed to evaluate aortic stiffness measures as predictors of progressive aortic dilation by cardiac magnetic resonance (CMR) in BAV patients. Methods: This is a retrospective study of 49 patients with BAV (median age 21.1 years at first CMR visit) with ≥2 CMR at the Wisconsin Adult Congenital Heart Disease Program (WAtCH). Circumferential aortic strain, distensibility, and β-stiffness index were obtained from CMR-derived aortic root cine imaging, and aortic dimensions were measured at aortic root and ascending aorta. A linear mixed-model and logistic regression were used to identify important predictors of progressive aortic dilation. Results: Over a median of 3.8 years follow-up, the annual growth rates of aortic root and ascending aorta dimensions were 0.25 and 0.16 mm/year, respectively. Aortic strain and distensibility decreased while β-stiffness index increased with age. Aortic root strain and distensibility were associated with progressive dilation of the ascending aorta. Baseline aortic root diameter was an independent predictor of >1 mm/year growth rate of the aortic root (adjusted OR 1.34, 95 % CI 1.03–1.74, p = 0.028). Most patients (61 %) had coexisting coarctation of aorta. Despite the higher prevalence of hypertension in patients with aortic coarctation, hypertension or coarctation had no effect on baseline aorta dimensions, stiffness, or progressive aortic dilation. Conclusion: Some CMR-derived aortic stiffness parameters correlated with progressive aortic dilation in BAV and should be further investigated in larger and older BAV cohorts. |
| first_indexed | 2024-04-12T06:31:16Z |
| format | Article |
| id | doaj.art-41e6156d8ca64f15ad02abf31e206dd9 |
| institution | Directory Open Access Journal |
| issn | 2666-6022 |
| language | English |
| last_indexed | 2024-04-12T06:31:16Z |
| publishDate | 2022-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | American Heart Journal Plus |
| spelling | doaj.art-41e6156d8ca64f15ad02abf31e206dd92022-12-22T03:44:00ZengElsevierAmerican Heart Journal Plus2666-60222022-08-0120100194The association between cardiac magnetic resonance-derived aortic stiffness parameters and aortic dilation in young adults with bicuspid aortic valve: With and without coarctation of aortaVasutakarn Chongthammakun0Amy Y. Pan1Michael G. Earing2Abdulla A. Damluji3Benjamin H. Goot4Joseph R. Cava5Jennifer F. Gerardin6Adult Congenital Heart Disease Program, Division of Cardiology, Virginia Commonwealth University, Richmond, VA, United States of America; Herma Heart Institute, Medical College of Wisconsin, Milwaukee, WI, United States of America; Corresponding author at: Adult Congenital Heart Disease Program, Division of Cardiology, Virginia Commonwealth University, 1200 E Broad St, Richmond, VA 23219, United States of America.Division of Quantitative Health Sciences, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI, United States of AmericaSections of Cardiology and Pediatric Cardiology, University of Chicago, Chicago, IL, United States of AmericaInova Center of Outcomes Research, Inova Heart and Vascular Institute, Falls Church, VA, United States of America; Division of Cardiology, Johns Hopkins University, Baltimore, MD, United States of AmericaHerma Heart Institute, Medical College of Wisconsin, Milwaukee, WI, United States of AmericaHerma Heart Institute, Medical College of Wisconsin, Milwaukee, WI, United States of AmericaHerma Heart Institute, Medical College of Wisconsin, Milwaukee, WI, United States of AmericaBackground: Bicuspid aortic valve (BAV) is associated with progressive aortic dilation. Studies in aortopathies have shown a correlation between increased aortic stiffness and aortic dilation. We aimed to evaluate aortic stiffness measures as predictors of progressive aortic dilation by cardiac magnetic resonance (CMR) in BAV patients. Methods: This is a retrospective study of 49 patients with BAV (median age 21.1 years at first CMR visit) with ≥2 CMR at the Wisconsin Adult Congenital Heart Disease Program (WAtCH). Circumferential aortic strain, distensibility, and β-stiffness index were obtained from CMR-derived aortic root cine imaging, and aortic dimensions were measured at aortic root and ascending aorta. A linear mixed-model and logistic regression were used to identify important predictors of progressive aortic dilation. Results: Over a median of 3.8 years follow-up, the annual growth rates of aortic root and ascending aorta dimensions were 0.25 and 0.16 mm/year, respectively. Aortic strain and distensibility decreased while β-stiffness index increased with age. Aortic root strain and distensibility were associated with progressive dilation of the ascending aorta. Baseline aortic root diameter was an independent predictor of >1 mm/year growth rate of the aortic root (adjusted OR 1.34, 95 % CI 1.03–1.74, p = 0.028). Most patients (61 %) had coexisting coarctation of aorta. Despite the higher prevalence of hypertension in patients with aortic coarctation, hypertension or coarctation had no effect on baseline aorta dimensions, stiffness, or progressive aortic dilation. Conclusion: Some CMR-derived aortic stiffness parameters correlated with progressive aortic dilation in BAV and should be further investigated in larger and older BAV cohorts.http://www.sciencedirect.com/science/article/pii/S2666602222001112Bicuspid aortic valveAortaAortic coarctationVascular stiffness |
| spellingShingle | Vasutakarn Chongthammakun Amy Y. Pan Michael G. Earing Abdulla A. Damluji Benjamin H. Goot Joseph R. Cava Jennifer F. Gerardin The association between cardiac magnetic resonance-derived aortic stiffness parameters and aortic dilation in young adults with bicuspid aortic valve: With and without coarctation of aorta American Heart Journal Plus Bicuspid aortic valve Aorta Aortic coarctation Vascular stiffness |
| title | The association between cardiac magnetic resonance-derived aortic stiffness parameters and aortic dilation in young adults with bicuspid aortic valve: With and without coarctation of aorta |
| title_full | The association between cardiac magnetic resonance-derived aortic stiffness parameters and aortic dilation in young adults with bicuspid aortic valve: With and without coarctation of aorta |
| title_fullStr | The association between cardiac magnetic resonance-derived aortic stiffness parameters and aortic dilation in young adults with bicuspid aortic valve: With and without coarctation of aorta |
| title_full_unstemmed | The association between cardiac magnetic resonance-derived aortic stiffness parameters and aortic dilation in young adults with bicuspid aortic valve: With and without coarctation of aorta |
| title_short | The association between cardiac magnetic resonance-derived aortic stiffness parameters and aortic dilation in young adults with bicuspid aortic valve: With and without coarctation of aorta |
| title_sort | association between cardiac magnetic resonance derived aortic stiffness parameters and aortic dilation in young adults with bicuspid aortic valve with and without coarctation of aorta |
| topic | Bicuspid aortic valve Aorta Aortic coarctation Vascular stiffness |
| url | http://www.sciencedirect.com/science/article/pii/S2666602222001112 |
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