Relationship of High Sensitivity C-Reactive Protein Levels to Anthropometric and other Metabolic Parameters in Indian Children with Simple Overweight and Obesity
Context: High senstivity C-reactive protein (hsCRP) levels correlate well other parameters of obesity related metabolic syndrome (MS) and can be used as predictors of future cardiovascular disease risk. There is limited data on hsCRP levels in Indian children with simple obesity. Aim: To study...
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| Format: | Article |
| Language: | English |
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JCDR Research and Publications Private Limited
2014-08-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/4685/8191_CE(Ra)_F(Sh)_PF1(PAK)_PFA(AK).pdf |
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| author | Devi Dayal Hemant Jain Savita Verma Attri Bhavneet Bharti Anil Kumar Bhalla |
| author_facet | Devi Dayal Hemant Jain Savita Verma Attri Bhavneet Bharti Anil Kumar Bhalla |
| author_sort | Devi Dayal |
| collection | DOAJ |
| description | Context: High senstivity C-reactive protein (hsCRP) levels
correlate well other parameters of obesity related metabolic
syndrome (MS) and can be used as predictors of future
cardiovascular disease risk. There is limited data on hsCRP
levels in Indian children with simple obesity.
Aim: To study the relationship of hsCRP levels with various
anthropometric as well as metabolic parameters in children with
simple overweight and obesity.
Materials and Methods: This case control study was
conducted in Paediatric Endocrinology clinic of a tertiary care
hospital in Northern India. Levels of hsCRP were estimated
in 100 overweight and obese children (BMI between 85th and
95th percentiles according to age & gender specific CDC 2000
growth charts) aged between 6 and 16 years and in 100 nearly
age and sex matched healthy controls. These levels were then
correlated to various anthropometric (body mass index, BMI;
waist circumference, WC; hip circumference, HC; waist hip
ratio, WHR; blood pressure) and biochemical (fasting blood
glucose, FBG; total cholesterol, TC; high-density lipoproteincholesterol, HDL-C; low-density lipoprotein cholesterol, LDL-C;
very low-density lipoprotein-cholesterol, VLDL-C; triglycerides,
TG) parameters.
Results: Mean levels of hsCRP were significantly higher in the
study group (3.92±2.20 versus 2.15±1.05 mg/L) as compared to
controls. Significantly more (58% versus 10%) subjects in the
study group had hsCRP (>3 mg/L). Of all the parameters studied,
only BMI showed a positive correlation with hsCRP levels in the
study group. Multiple logistic regression analysis for predicting
outcome of high hsCRP showed positive correlation with BMI;
with every 1 kg/m2
increase in BMI, odds of high hsCRP level
were increased by 37% (OR=1.37; 95% CI 1.23-1.53, p-value
<0.0001). Mean values of all the biochemical parameters except
HDL-C were significantly higher in the study group.
Conclusion: Levels of hsCRP were significantly elevated in
overweight and obese children as compared to non-obese
children. In addition, these patients also showed abnormalities
of lipid and glucose metabolism. |
| first_indexed | 2024-04-13T01:47:15Z |
| format | Article |
| id | doaj.art-41e80a113ef74421ab1dd8c1e58a594d |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-04-13T01:47:15Z |
| publishDate | 2014-08-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-41e80a113ef74421ab1dd8c1e58a594d2022-12-22T03:07:59ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2014-08-0188PC05PC0810.7860/JCDR/2014/8191.4685Relationship of High Sensitivity C-Reactive Protein Levels to Anthropometric and other Metabolic Parameters in Indian Children with Simple Overweight and ObesityDevi Dayal0Hemant Jain1Savita Verma Attri2Bhavneet Bharti3Anil Kumar Bhalla4Associate Professor, Department of Pediatrics, Advanced Pediatrics Center, Postgraduate Institute of Medical Education and Research, Chandigarh, India.Registrar, Department of Pediatrics, Advanced Pediatrics Center, Postgraduate Institute of Medical Education and Research, Chandigarh, India.Associate Professor, Department of Pediatrics, Advanced Pediatrics Center, Postgraduate Institute of Medical Education and Research, Chandigarh, India.Associate Professor, Department of Pediatrics, Advanced Pediatrics Center, Postgraduate Institute of Medical Education and Research, Chandigarh, India.Professor, Department of Pediatrics, Advanced Pediatrics Center, Postgraduate Institute of Medical Education and Research, Chandigarh, India.Context: High senstivity C-reactive protein (hsCRP) levels correlate well other parameters of obesity related metabolic syndrome (MS) and can be used as predictors of future cardiovascular disease risk. There is limited data on hsCRP levels in Indian children with simple obesity. Aim: To study the relationship of hsCRP levels with various anthropometric as well as metabolic parameters in children with simple overweight and obesity. Materials and Methods: This case control study was conducted in Paediatric Endocrinology clinic of a tertiary care hospital in Northern India. Levels of hsCRP were estimated in 100 overweight and obese children (BMI between 85th and 95th percentiles according to age & gender specific CDC 2000 growth charts) aged between 6 and 16 years and in 100 nearly age and sex matched healthy controls. These levels were then correlated to various anthropometric (body mass index, BMI; waist circumference, WC; hip circumference, HC; waist hip ratio, WHR; blood pressure) and biochemical (fasting blood glucose, FBG; total cholesterol, TC; high-density lipoproteincholesterol, HDL-C; low-density lipoprotein cholesterol, LDL-C; very low-density lipoprotein-cholesterol, VLDL-C; triglycerides, TG) parameters. Results: Mean levels of hsCRP were significantly higher in the study group (3.92±2.20 versus 2.15±1.05 mg/L) as compared to controls. Significantly more (58% versus 10%) subjects in the study group had hsCRP (>3 mg/L). Of all the parameters studied, only BMI showed a positive correlation with hsCRP levels in the study group. Multiple logistic regression analysis for predicting outcome of high hsCRP showed positive correlation with BMI; with every 1 kg/m2 increase in BMI, odds of high hsCRP level were increased by 37% (OR=1.37; 95% CI 1.23-1.53, p-value <0.0001). Mean values of all the biochemical parameters except HDL-C were significantly higher in the study group. Conclusion: Levels of hsCRP were significantly elevated in overweight and obese children as compared to non-obese children. In addition, these patients also showed abnormalities of lipid and glucose metabolism.https://jcdr.net/articles/PDF/4685/8191_CE(Ra)_F(Sh)_PF1(PAK)_PFA(AK).pdfchildhood obesitysubclinical inflammationhscrp levels |
| spellingShingle | Devi Dayal Hemant Jain Savita Verma Attri Bhavneet Bharti Anil Kumar Bhalla Relationship of High Sensitivity C-Reactive Protein Levels to Anthropometric and other Metabolic Parameters in Indian Children with Simple Overweight and Obesity Journal of Clinical and Diagnostic Research childhood obesity subclinical inflammation hscrp levels |
| title | Relationship of High Sensitivity C-Reactive Protein Levels to Anthropometric and other Metabolic Parameters in Indian Children with Simple Overweight and Obesity |
| title_full | Relationship of High Sensitivity C-Reactive Protein Levels to Anthropometric and other Metabolic Parameters in Indian Children with Simple Overweight and Obesity |
| title_fullStr | Relationship of High Sensitivity C-Reactive Protein Levels to Anthropometric and other Metabolic Parameters in Indian Children with Simple Overweight and Obesity |
| title_full_unstemmed | Relationship of High Sensitivity C-Reactive Protein Levels to Anthropometric and other Metabolic Parameters in Indian Children with Simple Overweight and Obesity |
| title_short | Relationship of High Sensitivity C-Reactive Protein Levels to Anthropometric and other Metabolic Parameters in Indian Children with Simple Overweight and Obesity |
| title_sort | relationship of high sensitivity c reactive protein levels to anthropometric and other metabolic parameters in indian children with simple overweight and obesity |
| topic | childhood obesity subclinical inflammation hscrp levels |
| url | https://jcdr.net/articles/PDF/4685/8191_CE(Ra)_F(Sh)_PF1(PAK)_PFA(AK).pdf |
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