Temperature-Dependent Activity of Motor Proteins: Energetics and Their Implications for Collective Behavior
Molecular motor proteins are an extremely important component of the cellular transport system that harness chemical energy derived from ATP hydrolysis to carry out directed mechanical motion inside the cells. Transport properties of these motors such as processivity, velocity, and their load depend...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-02-01
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| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2021.610899/full |
| _version_ | 1818428503171792896 |
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| author | Saumya Yadav Ambarish Kunwar |
| author_facet | Saumya Yadav Ambarish Kunwar |
| author_sort | Saumya Yadav |
| collection | DOAJ |
| description | Molecular motor proteins are an extremely important component of the cellular transport system that harness chemical energy derived from ATP hydrolysis to carry out directed mechanical motion inside the cells. Transport properties of these motors such as processivity, velocity, and their load dependence have been well established through single-molecule experiments. Temperature dependent biophysical properties of molecular motors are now being probed using single-molecule experiments. Additionally, the temperature dependent biochemical properties of motors (ATPase activity) are probed to understand the underlying mechanisms and their possible implications on the enzymatic activity of motor proteins. These experiments in turn have revealed their activation energies and how they compare with the thermal energy available from the surrounding medium. In this review, we summarize such temperature dependent biophysical and biochemical properties of linear and rotary motor proteins and their implications for collective function during intracellular transport and cellular movement, respectively. |
| first_indexed | 2024-12-14T15:02:39Z |
| format | Article |
| id | doaj.art-41e89d57dd0946fc9b5a75bf2441cf4c |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-14T15:02:39Z |
| publishDate | 2021-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-41e89d57dd0946fc9b5a75bf2441cf4c2022-12-21T22:56:46ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2021-02-01910.3389/fcell.2021.610899610899Temperature-Dependent Activity of Motor Proteins: Energetics and Their Implications for Collective BehaviorSaumya YadavAmbarish KunwarMolecular motor proteins are an extremely important component of the cellular transport system that harness chemical energy derived from ATP hydrolysis to carry out directed mechanical motion inside the cells. Transport properties of these motors such as processivity, velocity, and their load dependence have been well established through single-molecule experiments. Temperature dependent biophysical properties of molecular motors are now being probed using single-molecule experiments. Additionally, the temperature dependent biochemical properties of motors (ATPase activity) are probed to understand the underlying mechanisms and their possible implications on the enzymatic activity of motor proteins. These experiments in turn have revealed their activation energies and how they compare with the thermal energy available from the surrounding medium. In this review, we summarize such temperature dependent biophysical and biochemical properties of linear and rotary motor proteins and their implications for collective function during intracellular transport and cellular movement, respectively.https://www.frontiersin.org/articles/10.3389/fcell.2021.610899/fulltemperaturekinesindyneinmyosinarrheniusmolecular motor |
| spellingShingle | Saumya Yadav Ambarish Kunwar Temperature-Dependent Activity of Motor Proteins: Energetics and Their Implications for Collective Behavior Frontiers in Cell and Developmental Biology temperature kinesin dynein myosin arrhenius molecular motor |
| title | Temperature-Dependent Activity of Motor Proteins: Energetics and Their Implications for Collective Behavior |
| title_full | Temperature-Dependent Activity of Motor Proteins: Energetics and Their Implications for Collective Behavior |
| title_fullStr | Temperature-Dependent Activity of Motor Proteins: Energetics and Their Implications for Collective Behavior |
| title_full_unstemmed | Temperature-Dependent Activity of Motor Proteins: Energetics and Their Implications for Collective Behavior |
| title_short | Temperature-Dependent Activity of Motor Proteins: Energetics and Their Implications for Collective Behavior |
| title_sort | temperature dependent activity of motor proteins energetics and their implications for collective behavior |
| topic | temperature kinesin dynein myosin arrhenius molecular motor |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2021.610899/full |
| work_keys_str_mv | AT saumyayadav temperaturedependentactivityofmotorproteinsenergeticsandtheirimplicationsforcollectivebehavior AT ambarishkunwar temperaturedependentactivityofmotorproteinsenergeticsandtheirimplicationsforcollectivebehavior |