Is Corticosteroid Treatment Beneficial in Sudden Sensorineural Hearing Loss? A Large Retrospective Study
The main treatment approaches for sudden sensorineural hearing loss (SSNHL) involve oral and intratympanic corticosteroids, but their efficacy remains controversial. The study objective was to evaluate the benefit of oral corticosteroids followed by intratympanic salvage treatment. This was conducte...
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MDPI AG
2023-07-01
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| Series: | Applied Sciences |
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| Online Access: | https://www.mdpi.com/2076-3417/13/14/8546 |
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| author | Itay Chen Ronen Perez Shalom Eligal Ori Menahem Riki Salem Jean-Yves Sichel Chanan Shaul |
| author_facet | Itay Chen Ronen Perez Shalom Eligal Ori Menahem Riki Salem Jean-Yves Sichel Chanan Shaul |
| author_sort | Itay Chen |
| collection | DOAJ |
| description | The main treatment approaches for sudden sensorineural hearing loss (SSNHL) involve oral and intratympanic corticosteroids, but their efficacy remains controversial. The study objective was to evaluate the benefit of oral corticosteroids followed by intratympanic salvage treatment. This was conducted by comparing the hearing results of post-treatment patients arriving early and pretreatment patients arriving late over the same time points after the onset of HL. A cohort of 776 patients with SSNHL was classified into four groups by time from onset of symptoms to the initiation of treatment (weeks). The post-treatment audiometry of those patients presenting during the first and second week post-HL was compared to the pretreatment audiometry of those presenting in weeks three and four. The post-treatment audiometry of week one and pretreatment audiometry of week three was conducted 17.2 ± 4 and 19.4 ± 3 (<i>p</i> = 0.13) days post-HL onset, respectively. The post-treatment audiometry of week two and pretreatment audiometry of week four was conducted on days 24.6 ± 4 and 25.2 ± 3 (<i>p</i> = 0.32). The pure-tune average for week one and three groups was 36.7 ± 28 and 37.5 ± 19 dB (<i>p</i> = 0.55), and for weeks 2 and 4, it was 31.7 ± 22 and 36.6 ± 23 dB (<i>p</i> = 0.1). Similarly, no significant differences in speech recognition threshold and speech discrimination were found. These results question the benefit of corticosteroid treatment for SSNHL and suggest that improvements may be due to the natural healing process. |
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| issn | 2076-3417 |
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| last_indexed | 2024-03-11T01:19:25Z |
| publishDate | 2023-07-01 |
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| series | Applied Sciences |
| spelling | doaj.art-41e99629de4240879b15a85c03e071ee2023-11-18T18:14:36ZengMDPI AGApplied Sciences2076-34172023-07-011314854610.3390/app13148546Is Corticosteroid Treatment Beneficial in Sudden Sensorineural Hearing Loss? A Large Retrospective StudyItay Chen0Ronen Perez1Shalom Eligal2Ori Menahem3Riki Salem4Jean-Yves Sichel5Chanan Shaul6Shaare-Zedek Medical Center, Department of Otolaryngology, Head and Neck Surgery, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 90938, IsraelShaare-Zedek Medical Center, Department of Otolaryngology, Head and Neck Surgery, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 90938, IsraelShaare-Zedek Medical Center, Department of Otolaryngology, Head and Neck Surgery, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 90938, IsraelShaare-Zedek Medical Center, Department of Otolaryngology, Head and Neck Surgery, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 90938, IsraelShaare-Zedek Medical Center, Department of Otolaryngology, Head and Neck Surgery, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 90938, IsraelShaare-Zedek Medical Center, Department of Otolaryngology, Head and Neck Surgery, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 90938, IsraelShaare-Zedek Medical Center, Department of Otolaryngology, Head and Neck Surgery, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 90938, IsraelThe main treatment approaches for sudden sensorineural hearing loss (SSNHL) involve oral and intratympanic corticosteroids, but their efficacy remains controversial. The study objective was to evaluate the benefit of oral corticosteroids followed by intratympanic salvage treatment. This was conducted by comparing the hearing results of post-treatment patients arriving early and pretreatment patients arriving late over the same time points after the onset of HL. A cohort of 776 patients with SSNHL was classified into four groups by time from onset of symptoms to the initiation of treatment (weeks). The post-treatment audiometry of those patients presenting during the first and second week post-HL was compared to the pretreatment audiometry of those presenting in weeks three and four. The post-treatment audiometry of week one and pretreatment audiometry of week three was conducted 17.2 ± 4 and 19.4 ± 3 (<i>p</i> = 0.13) days post-HL onset, respectively. The post-treatment audiometry of week two and pretreatment audiometry of week four was conducted on days 24.6 ± 4 and 25.2 ± 3 (<i>p</i> = 0.32). The pure-tune average for week one and three groups was 36.7 ± 28 and 37.5 ± 19 dB (<i>p</i> = 0.55), and for weeks 2 and 4, it was 31.7 ± 22 and 36.6 ± 23 dB (<i>p</i> = 0.1). Similarly, no significant differences in speech recognition threshold and speech discrimination were found. These results question the benefit of corticosteroid treatment for SSNHL and suggest that improvements may be due to the natural healing process.https://www.mdpi.com/2076-3417/13/14/8546hearing losscorticosteroidsaudiogramintratympanic injectionspeech discrimination |
| spellingShingle | Itay Chen Ronen Perez Shalom Eligal Ori Menahem Riki Salem Jean-Yves Sichel Chanan Shaul Is Corticosteroid Treatment Beneficial in Sudden Sensorineural Hearing Loss? A Large Retrospective Study Applied Sciences hearing loss corticosteroids audiogram intratympanic injection speech discrimination |
| title | Is Corticosteroid Treatment Beneficial in Sudden Sensorineural Hearing Loss? A Large Retrospective Study |
| title_full | Is Corticosteroid Treatment Beneficial in Sudden Sensorineural Hearing Loss? A Large Retrospective Study |
| title_fullStr | Is Corticosteroid Treatment Beneficial in Sudden Sensorineural Hearing Loss? A Large Retrospective Study |
| title_full_unstemmed | Is Corticosteroid Treatment Beneficial in Sudden Sensorineural Hearing Loss? A Large Retrospective Study |
| title_short | Is Corticosteroid Treatment Beneficial in Sudden Sensorineural Hearing Loss? A Large Retrospective Study |
| title_sort | is corticosteroid treatment beneficial in sudden sensorineural hearing loss a large retrospective study |
| topic | hearing loss corticosteroids audiogram intratympanic injection speech discrimination |
| url | https://www.mdpi.com/2076-3417/13/14/8546 |
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