Molecular mechanisms of glial cells in brain disorders following physical exercise
Physical exercise generally improves health in humans and animals and may enhance cognitive function and neural function in the brain, especially in the prefrontal cortex and hippocampus. It is also a promising intervention for brain disorders such as psychiatric conditions and neurodegenerative dis...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Tsinghua University Press
2023-12-01
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| Series: | Stress and Brain |
| Subjects: | |
| Online Access: | https://www.sciopen.com/article/10.26599/SAB.2023.9060004 |
| _version_ | 1797354866471862272 |
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| author | Yan Liu Shuzhen Ran Kwok-Fai So Li Zhang |
| author_facet | Yan Liu Shuzhen Ran Kwok-Fai So Li Zhang |
| author_sort | Yan Liu |
| collection | DOAJ |
| description | Physical exercise generally improves health in humans and animals and may enhance cognitive function and neural function in the brain, especially in the prefrontal cortex and hippocampus. It is also a promising intervention for brain disorders such as psychiatric conditions and neurodegenerative diseases. The neuroprotective mechanisms of exercise are related to synaptic plasticity, neurogenesis, and autophagy. Moreover, the therapeutic effects of exercise are associated with glial cell function in the brain. In this review, we examine the relationship between glial cell function and brain disorders. We also consider the role of glial cells in modulating the effects of exercise on the molecular mechanisms and neural circuits involved in central and peripheral brain function. This review demonstrates that glial cells may play an important role in the effects of physical exercise interventions on the brain, particularly in those with neurological disorders. |
| first_indexed | 2024-03-08T13:55:59Z |
| format | Article |
| id | doaj.art-41e9d9230c6048d1a8c423ff82ff2bbf |
| institution | Directory Open Access Journal |
| issn | 2709-1325 2709-0388 |
| language | English |
| last_indexed | 2024-03-08T13:55:59Z |
| publishDate | 2023-12-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Stress and Brain |
| spelling | doaj.art-41e9d9230c6048d1a8c423ff82ff2bbf2024-01-15T14:52:50ZengTsinghua University PressStress and Brain2709-13252709-03882023-12-013417919010.26599/SAB.2023.9060004Molecular mechanisms of glial cells in brain disorders following physical exerciseYan Liu0Shuzhen Ran1Kwok-Fai So2Li Zhang3School of Traditional Chinese Medicine, Jinan University, 510632 Guangzhou, ChinaSchool of Traditional Chinese Medicine, Jinan University, 510632 Guangzhou, ChinaKey Laboratory of CNS Regeneration (Ministry of Education), Guangdong-Hong Kong-Macau Institute of CNS Regeneration, Jinan University, 510632 Guangzhou, ChinaKey Laboratory of CNS Regeneration (Ministry of Education), Guangdong-Hong Kong-Macau Institute of CNS Regeneration, Jinan University, 510632 Guangzhou, ChinaPhysical exercise generally improves health in humans and animals and may enhance cognitive function and neural function in the brain, especially in the prefrontal cortex and hippocampus. It is also a promising intervention for brain disorders such as psychiatric conditions and neurodegenerative diseases. The neuroprotective mechanisms of exercise are related to synaptic plasticity, neurogenesis, and autophagy. Moreover, the therapeutic effects of exercise are associated with glial cell function in the brain. In this review, we examine the relationship between glial cell function and brain disorders. We also consider the role of glial cells in modulating the effects of exercise on the molecular mechanisms and neural circuits involved in central and peripheral brain function. This review demonstrates that glial cells may play an important role in the effects of physical exercise interventions on the brain, particularly in those with neurological disorders.https://www.sciopen.com/article/10.26599/SAB.2023.9060004exerciseglial cellsneural network |
| spellingShingle | Yan Liu Shuzhen Ran Kwok-Fai So Li Zhang Molecular mechanisms of glial cells in brain disorders following physical exercise Stress and Brain exercise glial cells neural network |
| title | Molecular mechanisms of glial cells in brain disorders following physical exercise |
| title_full | Molecular mechanisms of glial cells in brain disorders following physical exercise |
| title_fullStr | Molecular mechanisms of glial cells in brain disorders following physical exercise |
| title_full_unstemmed | Molecular mechanisms of glial cells in brain disorders following physical exercise |
| title_short | Molecular mechanisms of glial cells in brain disorders following physical exercise |
| title_sort | molecular mechanisms of glial cells in brain disorders following physical exercise |
| topic | exercise glial cells neural network |
| url | https://www.sciopen.com/article/10.26599/SAB.2023.9060004 |
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