Astragalin Suppresses Inflammatory Responses and Bone Destruction in Mice With Collagen-Induced Arthritis and in Human Fibroblast-Like Synoviocytes

Astragalin Suppresses Inflammatory Responses and Bone Destruction in Mice With Collagen-Induced Arthritis and in Human Fibroblast-Like Synoviocytes

Astragalin, as a bioactive flavonoid with anti-inflammatory, antioxidant, and protective properties, provides a potential agent for rheumatoid arthritis (RA). In this study, its therapeutic efficacy and the underlying mechanisms were explored using DBA/1J mice with collagen-induced arthritis (CIA)....

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Bibliographic Details
Main Authors: Qingyun Jia, Tengteng Wang, Xiaoyun Wang, Hao Xu, Yang Liu, Yongjun Wang, Qi Shi, Qianqian Liang
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Pharmacology
Subjects:
astragalin
rheumatoid arthritis
matrix metalloproteinase
CIA
fibroblast-like synoviocytes
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00094/full

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