The Aspergillus nidulans MAPK module AnSte11-Ste50-Ste7-Fus3 controls development and secondary metabolism.
The sexual Fus3 MAP kinase module of yeast is highly conserved in eukaryotes and transmits external signals from the plasma membrane to the nucleus. We show here that the module of the filamentous fungus Aspergillus nidulans (An) consists of the AnFus3 MAP kinase, the upstream kinases AnSte7 and AnS...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2012-01-01
|
| Series: | PLoS Genetics |
| Online Access: | http://europepmc.org/articles/PMC3400554?pdf=render |
| _version_ | 1819028741624430592 |
|---|---|
| author | Özgür Bayram Özlem Sarikaya Bayram Yasar Luqman Ahmed Jun-Ichi Maruyama Oliver Valerius Silvio O Rizzoli Ralf Ficner Stefan Irniger Gerhard H Braus |
| author_facet | Özgür Bayram Özlem Sarikaya Bayram Yasar Luqman Ahmed Jun-Ichi Maruyama Oliver Valerius Silvio O Rizzoli Ralf Ficner Stefan Irniger Gerhard H Braus |
| author_sort | Özgür Bayram |
| collection | DOAJ |
| description | The sexual Fus3 MAP kinase module of yeast is highly conserved in eukaryotes and transmits external signals from the plasma membrane to the nucleus. We show here that the module of the filamentous fungus Aspergillus nidulans (An) consists of the AnFus3 MAP kinase, the upstream kinases AnSte7 and AnSte11, and the AnSte50 adaptor. The fungal MAPK module controls the coordination of fungal development and secondary metabolite production. It lacks the membrane docking yeast Ste5 scaffold homolog; but, similar to yeast, the entire MAPK module's proteins interact with each other at the plasma membrane. AnFus3 is the only subunit with the potential to enter the nucleus from the nuclear envelope. AnFus3 interacts with the conserved nuclear transcription factor AnSte12 to initiate sexual development and phosphorylates VeA, which is a major regulatory protein required for sexual development and coordinated secondary metabolite production. Our data suggest that not only Fus3, but even the entire MAPK module complex of four physically interacting proteins, can migrate from plasma membrane to nuclear envelope. |
| first_indexed | 2024-12-21T06:03:11Z |
| format | Article |
| id | doaj.art-41ec0f5482b047158772f49ab4b1b51d |
| institution | Directory Open Access Journal |
| issn | 1553-7390 1553-7404 |
| language | English |
| last_indexed | 2024-12-21T06:03:11Z |
| publishDate | 2012-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Genetics |
| spelling | doaj.art-41ec0f5482b047158772f49ab4b1b51d2022-12-21T19:13:42ZengPublic Library of Science (PLoS)PLoS Genetics1553-73901553-74042012-01-0187e100281610.1371/journal.pgen.1002816The Aspergillus nidulans MAPK module AnSte11-Ste50-Ste7-Fus3 controls development and secondary metabolism.Özgür BayramÖzlem Sarikaya BayramYasar Luqman AhmedJun-Ichi MaruyamaOliver ValeriusSilvio O RizzoliRalf FicnerStefan IrnigerGerhard H BrausThe sexual Fus3 MAP kinase module of yeast is highly conserved in eukaryotes and transmits external signals from the plasma membrane to the nucleus. We show here that the module of the filamentous fungus Aspergillus nidulans (An) consists of the AnFus3 MAP kinase, the upstream kinases AnSte7 and AnSte11, and the AnSte50 adaptor. The fungal MAPK module controls the coordination of fungal development and secondary metabolite production. It lacks the membrane docking yeast Ste5 scaffold homolog; but, similar to yeast, the entire MAPK module's proteins interact with each other at the plasma membrane. AnFus3 is the only subunit with the potential to enter the nucleus from the nuclear envelope. AnFus3 interacts with the conserved nuclear transcription factor AnSte12 to initiate sexual development and phosphorylates VeA, which is a major regulatory protein required for sexual development and coordinated secondary metabolite production. Our data suggest that not only Fus3, but even the entire MAPK module complex of four physically interacting proteins, can migrate from plasma membrane to nuclear envelope.http://europepmc.org/articles/PMC3400554?pdf=render |
| spellingShingle | Özgür Bayram Özlem Sarikaya Bayram Yasar Luqman Ahmed Jun-Ichi Maruyama Oliver Valerius Silvio O Rizzoli Ralf Ficner Stefan Irniger Gerhard H Braus The Aspergillus nidulans MAPK module AnSte11-Ste50-Ste7-Fus3 controls development and secondary metabolism. PLoS Genetics |
| title | The Aspergillus nidulans MAPK module AnSte11-Ste50-Ste7-Fus3 controls development and secondary metabolism. |
| title_full | The Aspergillus nidulans MAPK module AnSte11-Ste50-Ste7-Fus3 controls development and secondary metabolism. |
| title_fullStr | The Aspergillus nidulans MAPK module AnSte11-Ste50-Ste7-Fus3 controls development and secondary metabolism. |
| title_full_unstemmed | The Aspergillus nidulans MAPK module AnSte11-Ste50-Ste7-Fus3 controls development and secondary metabolism. |
| title_short | The Aspergillus nidulans MAPK module AnSte11-Ste50-Ste7-Fus3 controls development and secondary metabolism. |
| title_sort | aspergillus nidulans mapk module anste11 ste50 ste7 fus3 controls development and secondary metabolism |
| url | http://europepmc.org/articles/PMC3400554?pdf=render |
| work_keys_str_mv | AT ozgurbayram theaspergillusnidulansmapkmoduleanste11ste50ste7fus3controlsdevelopmentandsecondarymetabolism AT ozlemsarikayabayram theaspergillusnidulansmapkmoduleanste11ste50ste7fus3controlsdevelopmentandsecondarymetabolism AT yasarluqmanahmed theaspergillusnidulansmapkmoduleanste11ste50ste7fus3controlsdevelopmentandsecondarymetabolism AT junichimaruyama theaspergillusnidulansmapkmoduleanste11ste50ste7fus3controlsdevelopmentandsecondarymetabolism AT olivervalerius theaspergillusnidulansmapkmoduleanste11ste50ste7fus3controlsdevelopmentandsecondarymetabolism AT silvioorizzoli theaspergillusnidulansmapkmoduleanste11ste50ste7fus3controlsdevelopmentandsecondarymetabolism AT ralfficner theaspergillusnidulansmapkmoduleanste11ste50ste7fus3controlsdevelopmentandsecondarymetabolism AT stefanirniger theaspergillusnidulansmapkmoduleanste11ste50ste7fus3controlsdevelopmentandsecondarymetabolism AT gerhardhbraus theaspergillusnidulansmapkmoduleanste11ste50ste7fus3controlsdevelopmentandsecondarymetabolism AT ozgurbayram aspergillusnidulansmapkmoduleanste11ste50ste7fus3controlsdevelopmentandsecondarymetabolism AT ozlemsarikayabayram aspergillusnidulansmapkmoduleanste11ste50ste7fus3controlsdevelopmentandsecondarymetabolism AT yasarluqmanahmed aspergillusnidulansmapkmoduleanste11ste50ste7fus3controlsdevelopmentandsecondarymetabolism AT junichimaruyama aspergillusnidulansmapkmoduleanste11ste50ste7fus3controlsdevelopmentandsecondarymetabolism AT olivervalerius aspergillusnidulansmapkmoduleanste11ste50ste7fus3controlsdevelopmentandsecondarymetabolism AT silvioorizzoli aspergillusnidulansmapkmoduleanste11ste50ste7fus3controlsdevelopmentandsecondarymetabolism AT ralfficner aspergillusnidulansmapkmoduleanste11ste50ste7fus3controlsdevelopmentandsecondarymetabolism AT stefanirniger aspergillusnidulansmapkmoduleanste11ste50ste7fus3controlsdevelopmentandsecondarymetabolism AT gerhardhbraus aspergillusnidulansmapkmoduleanste11ste50ste7fus3controlsdevelopmentandsecondarymetabolism |