Plasma next generation sequencing and droplet digital PCR‐based detection of epidermal growth factor receptor (EGFR) mutations in patients with advanced lung cancer treated with subsequent‐line osimertinib

Plasma next generation sequencing and droplet digital PCR‐based detection of epidermal growth factor receptor (EGFR) mutations in patients with advanced lung cancer treated with subsequent‐line osimertinib

Background Gene mutation analysis from plasma circulating tumor DNA (ctDNA) can provide timely information regarding the mechanism of resistance that could translate to personalised treatment. We compared concordance rate of next generation sequencing (NGS) and droplet digital polymerase chain react...

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Bibliographic Details
Main Authors: Pei N. Ding, Therese Becker, Victoria Bray, Wei Chua, Yafeng Ma, Bo Xu, David Lynch, Paul de Souza, Tara Roberts
Format: Article
Language:English
Published: Wiley 2019-10-01
Series:Thoracic Cancer
Subjects:
Circulating tumor DNA
droplet digital PCR
next generation sequencing
plasma genotyping
resistance mechanisms
Online Access:https://doi.org/10.1111/1759-7714.13154

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