Synthesis, Molecular Docking Analysis, and Biological Evaluations of Saccharide-Modified Sulfonamides as Carbonic Anhydrase IX Inhibitors

Synthesis, Molecular Docking Analysis, and Biological Evaluations of Saccharide-Modified Sulfonamides as Carbonic Anhydrase IX Inhibitors

Based on the strategy of the “tail approach”, 15 novel saccharide-modified sulfonamides were designed and synthesised. The novel compounds were evaluated as inhibitors of three human carbonic anhydrase (CA) isoforms, namely cytoplasmic CA II, transmembrane CA IX, and XII. Most of these compounds sho...

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Bibliographic Details
Main Authors: Zuopeng Zhang, Huali Yang, Ye Zhong, Yueqing Wang, Jian Wang, Maosheng Cheng, Yang Liu
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:International Journal of Molecular Sciences
Subjects:
saccharide-modified sulfonamides
CA IX
cell viability
migration
molecular docking
Online Access:https://www.mdpi.com/1422-0067/22/24/13610

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