Complexes of Ibuprofen Thiazolidin-4-One Derivatives with β-Cyclodextrin: Characterization and In Vivo Release Profile and Biological Evaluation

Complexes of Ibuprofen Thiazolidin-4-One Derivatives with β-Cyclodextrin: Characterization and In Vivo Release Profile and Biological Evaluation

Generally, NSAIDs are weakly soluble in water and contain both hydrophilic and hydrophobic groups. One of the most widely used NSAIDs is ibuprofen, which has a poor solubility and high permeability profile. By creating dynamic, non-covalent, water-soluble inclusion complexes, cyclodextrins (CDs) can...

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Bibliographic Details
Main Authors: Ioana Mirela Vasincu, Maria Apotrosoaei, Florentina Lupascu, Andreea-Teodora Iacob, Simona-Eliza Giusca, Irina-Draga Caruntu, Narcisa-Laura Marangoci, Anca Roxana Petrovici, Gabriela Dumitrita Stanciu, Bogdan-Ionel Tamba, Bianca-Stefania Profire, Alin-Viorel Focsa, Mariana Pinteala, Lenuta Profire
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:Pharmaceutics
Subjects:
ibuprofen derivatives
β-cyclodextrin
release profile
analgesic assays
Online Access:https://www.mdpi.com/1999-4923/15/10/2492

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