Nuclear Fragility in Radiation-Induced Senescence: Blebs and Tubes Visualized by 3D Electron Microscopy

Nuclear Fragility in Radiation-Induced Senescence: Blebs and Tubes Visualized by 3D Electron Microscopy

Irreparable DNA damage following ionizing radiation (IR) triggers prolonged DNA damage response and induces premature senescence. Cellular senescence is a permanent state of cell-cycle arrest characterized by chromatin restructuring, altered nuclear morphology and acquisition of secretory phenotype,...

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Bibliographic Details
Main Authors: Benjamin M. Freyter, Mutaz A. Abd Al-razaq, Anna Isermann, Anne Dietz, Omid Azimzadeh, Liesbeth Hekking, Maria Gomolka, Claudia E. Rübe
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Cells
Subjects:
cellular senescence
ionizing radiation
radiation-induced senescence
chromatin reorganization
nuclear blebbing
transmission electron microscopy (TEM)
Online Access:https://www.mdpi.com/2073-4409/11/2/273

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