Targeting the C-terminus of galectin-9 induces mesothelioma apoptosis and M2 macrophage depletion

Targeting the C-terminus of galectin-9 induces mesothelioma apoptosis and M2 macrophage depletion

Galectin-9 has emerged as a promising biological target for cancer immunotherapy due to its role as a regulator of macrophage and T-cell differentiation. In addition, its expression in tumor cells modulates tumor cell adhesion, metastasis, and apoptosis. Malignant mesothelioma (MM) is an aggressive...

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Bibliographic Details
Main Authors: Pietro Bertino, Thomas A. Premeaux, Tsuyoshi Fujita, Brien K. Haun, Michael P. Marciel, Fukun W. Hoffmann, Alan Garcia, Haining Yiang, Sandra Pastorino, Michele Carbone, Toshiro Niki, John Berestecky, Peter R. Hoffmann, Lishomwa C. Ndhlovu
Format: Article
Language:English
Published: Taylor & Francis Group 2019-08-01
Series:OncoImmunology
Subjects:
lectins
galectin 9
mesothelioma
immunotherapy
macrophages
agonist monoclonal antibody
Online Access:http://dx.doi.org/10.1080/2162402X.2019.1601482

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