Comparing Local Recurrence and Distant Metastasis Between Breast-Conserving Therapy with Radiotherapy and Total Mastectomy in Candidates for PET/CT Assessment
Background: This study aimed to compare the recurrence rate of breast cancer between women treated with breast-conserving therapy (BCT) with/without radiotherapy and those treated with total mastectomy using 18F-fluorodeoxyglucose positron emission tomography/computed tomography18 (F-FDG PET/CT). Me...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Kaviani Breast Disease Institute
2021-01-01
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| Series: | Archives of Breast Cancer |
| Subjects: | |
| Online Access: | https://www.archbreastcancer.com/index.php/abc/article/view/348 |
| _version_ | 1818402581391605760 |
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| author | Abbas Yousefi-Koma Mehrdad Bakhshayeshkaram Homa Zamani Yalda Salehi Farahnaz Aghahosseini |
| author_facet | Abbas Yousefi-Koma Mehrdad Bakhshayeshkaram Homa Zamani Yalda Salehi Farahnaz Aghahosseini |
| author_sort | Abbas Yousefi-Koma |
| collection | DOAJ |
| description | Background: This study aimed to compare the recurrence rate of breast cancer between women treated with breast-conserving therapy (BCT) with/without radiotherapy and those treated with total mastectomy using 18F-fluorodeoxyglucose positron emission tomography/computed tomography18 (F-FDG PET/CT).
Methods: The current study retrospectively included 588 patients suffering from breast cancer who had been referred to the PET/CT department of Masih-e-Daneshvari Hospital in Tehran between April 2013 and September 2019. Data of all female patients with breast cancer were extracted from the recorded hospital files. Based on the treatment plan, patients were divided into two groups: BCT with/without radiotherapy (n=168) and total mastectomy (n=420). Local, locoregional, and distant metabolically active lesions were determined in18 F-FDG PET/CT and compared between groups.
Results: BCT and total mastectomy were comparable regarding local (28.5% vs. 25.7%, P=0.200) and locoregional (21.4% vs. 22.8%, P=0.712) recurrence, while distant recurrence was significantly higher with total mastectomy (88.5% vs. 64.2%, P<0.001). Also, lymph node invasion (42.9% vs. 60%m P<0.001) and positive PET/CT (78.5% vs. 88.5%, P=0.002) were significantly higher with total mastectomy.
According to multivariate analysis, age, clinical stage, positive margin are independently correlated with the rate of distant metastasis.
Conclusion: According to our analysis, breast-conserving therapy could be a suitable choice of surgery in selected patients since local and locoregional recurrence rate did not significantly differ between patients who underwent breast-conserving surgery compared to those who were treated with total mastectomy. Higher rate of distant metastasis in patients with total mastectomy seems to be influenced by many confounding variables such as age, higher stage of diagnosis and positive margin rather than type of surgery. |
| first_indexed | 2024-12-14T08:10:38Z |
| format | Article |
| id | doaj.art-41f45d52218f407badb6ba5d66b543fc |
| institution | Directory Open Access Journal |
| issn | 2383-0433 |
| language | English |
| last_indexed | 2024-12-14T08:10:38Z |
| publishDate | 2021-01-01 |
| publisher | Kaviani Breast Disease Institute |
| record_format | Article |
| series | Archives of Breast Cancer |
| spelling | doaj.art-41f45d52218f407badb6ba5d66b543fc2022-12-21T23:10:05ZengKaviani Breast Disease InstituteArchives of Breast Cancer2383-04332021-01-0110.32768/abc.20218157-62Comparing Local Recurrence and Distant Metastasis Between Breast-Conserving Therapy with Radiotherapy and Total Mastectomy in Candidates for PET/CT AssessmentAbbas Yousefi-Koma0Mehrdad Bakhshayeshkaram1Homa Zamani2Yalda Salehi3Farahnaz Aghahosseini4Department of Radiology, Shahid Beheshti University of Medical Sciences, Tehran, Iran AND Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD)Department of Radiology, Shahid Beheshti University of Medical Sciences, Tehran, Iran AND Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD)Department of Radiology, Shahid Beheshti University of Medical Sciences, Tehran, Iran AND Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD)Department of Nuclear Medicine, Imam Khomeini Hospital, Tehran University of Science, Tehran, IranPediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Department of RadiDepartment of Radiology, Shahid Beheshti University of Medical Sciences, Tehran, Iran AND Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD)ology, Shahid Beheshti University of Medical Sciences, Tehran, IranBackground: This study aimed to compare the recurrence rate of breast cancer between women treated with breast-conserving therapy (BCT) with/without radiotherapy and those treated with total mastectomy using 18F-fluorodeoxyglucose positron emission tomography/computed tomography18 (F-FDG PET/CT). Methods: The current study retrospectively included 588 patients suffering from breast cancer who had been referred to the PET/CT department of Masih-e-Daneshvari Hospital in Tehran between April 2013 and September 2019. Data of all female patients with breast cancer were extracted from the recorded hospital files. Based on the treatment plan, patients were divided into two groups: BCT with/without radiotherapy (n=168) and total mastectomy (n=420). Local, locoregional, and distant metabolically active lesions were determined in18 F-FDG PET/CT and compared between groups. Results: BCT and total mastectomy were comparable regarding local (28.5% vs. 25.7%, P=0.200) and locoregional (21.4% vs. 22.8%, P=0.712) recurrence, while distant recurrence was significantly higher with total mastectomy (88.5% vs. 64.2%, P<0.001). Also, lymph node invasion (42.9% vs. 60%m P<0.001) and positive PET/CT (78.5% vs. 88.5%, P=0.002) were significantly higher with total mastectomy. According to multivariate analysis, age, clinical stage, positive margin are independently correlated with the rate of distant metastasis. Conclusion: According to our analysis, breast-conserving therapy could be a suitable choice of surgery in selected patients since local and locoregional recurrence rate did not significantly differ between patients who underwent breast-conserving surgery compared to those who were treated with total mastectomy. Higher rate of distant metastasis in patients with total mastectomy seems to be influenced by many confounding variables such as age, higher stage of diagnosis and positive margin rather than type of surgery.https://www.archbreastcancer.com/index.php/abc/article/view/348breast cancerrecurrencebreast-conserving therapytotal mastectomyF18-FDG PET/CT |
| spellingShingle | Abbas Yousefi-Koma Mehrdad Bakhshayeshkaram Homa Zamani Yalda Salehi Farahnaz Aghahosseini Comparing Local Recurrence and Distant Metastasis Between Breast-Conserving Therapy with Radiotherapy and Total Mastectomy in Candidates for PET/CT Assessment Archives of Breast Cancer breast cancer recurrence breast-conserving therapy total mastectomy F18-FDG PET/CT |
| title | Comparing Local Recurrence and Distant Metastasis Between Breast-Conserving Therapy with Radiotherapy and Total Mastectomy in Candidates for PET/CT Assessment |
| title_full | Comparing Local Recurrence and Distant Metastasis Between Breast-Conserving Therapy with Radiotherapy and Total Mastectomy in Candidates for PET/CT Assessment |
| title_fullStr | Comparing Local Recurrence and Distant Metastasis Between Breast-Conserving Therapy with Radiotherapy and Total Mastectomy in Candidates for PET/CT Assessment |
| title_full_unstemmed | Comparing Local Recurrence and Distant Metastasis Between Breast-Conserving Therapy with Radiotherapy and Total Mastectomy in Candidates for PET/CT Assessment |
| title_short | Comparing Local Recurrence and Distant Metastasis Between Breast-Conserving Therapy with Radiotherapy and Total Mastectomy in Candidates for PET/CT Assessment |
| title_sort | comparing local recurrence and distant metastasis between breast conserving therapy with radiotherapy and total mastectomy in candidates for pet ct assessment |
| topic | breast cancer recurrence breast-conserving therapy total mastectomy F18-FDG PET/CT |
| url | https://www.archbreastcancer.com/index.php/abc/article/view/348 |
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