Rapid Raman Spectroscopic Analysis of Stress Induced Degradation of the Pharmaceutical Drug Tetracycline
Stress factors caused by inadequate storage can induce the unwanted degradation of active compounds in pharmaceutical formulations. Resonance Raman spectroscopy is presented as an analytical tool for rapid monitoring of small concentration changes of tetracycline and the metabolite 4˗epianhydrotetra...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-04-01
|
| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/25/8/1866 |
| _version_ | 1797570305129971712 |
|---|---|
| author | Christian Domes Timea Frosch Juergen Popp Torsten Frosch |
| author_facet | Christian Domes Timea Frosch Juergen Popp Torsten Frosch |
| author_sort | Christian Domes |
| collection | DOAJ |
| description | Stress factors caused by inadequate storage can induce the unwanted degradation of active compounds in pharmaceutical formulations. Resonance Raman spectroscopy is presented as an analytical tool for rapid monitoring of small concentration changes of tetracycline and the metabolite 4˗epianhydrotetracycline. These degradation processes were experimentally induced by changes in temperature, humidity, and irradiation with visible light over a time period of up to 23 days. The excitation wavelength <i>λ</i><sub>exc</sub> = 413 nm was proven to provide short acquisition times for the simultaneous Raman spectroscopic detection of the degradation of tetracycline and production of its impurity in small sample volumes. Small concentration changes could be detected (down to 1.4% for tetracycline and 0.3% for 4-epianhydrotetracycline), which shows the potential of resonance Raman spectroscopy for analyzing the decomposition of pharmaceutical products. |
| first_indexed | 2024-03-10T20:23:03Z |
| format | Article |
| id | doaj.art-41f7c5c8905a4181802a766bd8db2da5 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T20:23:03Z |
| publishDate | 2020-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-41f7c5c8905a4181802a766bd8db2da52023-11-19T21:59:44ZengMDPI AGMolecules1420-30492020-04-01258186610.3390/molecules25081866Rapid Raman Spectroscopic Analysis of Stress Induced Degradation of the Pharmaceutical Drug TetracyclineChristian Domes0Timea Frosch1Juergen Popp2Torsten Frosch3Leibniz Institute of Photonic Technology, 07745 Jena, GermanyLeibniz Institute of Photonic Technology, 07745 Jena, GermanyLeibniz Institute of Photonic Technology, 07745 Jena, GermanyLeibniz Institute of Photonic Technology, 07745 Jena, GermanyStress factors caused by inadequate storage can induce the unwanted degradation of active compounds in pharmaceutical formulations. Resonance Raman spectroscopy is presented as an analytical tool for rapid monitoring of small concentration changes of tetracycline and the metabolite 4˗epianhydrotetracycline. These degradation processes were experimentally induced by changes in temperature, humidity, and irradiation with visible light over a time period of up to 23 days. The excitation wavelength <i>λ</i><sub>exc</sub> = 413 nm was proven to provide short acquisition times for the simultaneous Raman spectroscopic detection of the degradation of tetracycline and production of its impurity in small sample volumes. Small concentration changes could be detected (down to 1.4% for tetracycline and 0.3% for 4-epianhydrotetracycline), which shows the potential of resonance Raman spectroscopy for analyzing the decomposition of pharmaceutical products.https://www.mdpi.com/1420-3049/25/8/1866resonance Raman spectroscopydrug monitoringactive pharmaceutical ingredientsantibioticsdrug degradationdecomposition of pharmaceutical products |
| spellingShingle | Christian Domes Timea Frosch Juergen Popp Torsten Frosch Rapid Raman Spectroscopic Analysis of Stress Induced Degradation of the Pharmaceutical Drug Tetracycline Molecules resonance Raman spectroscopy drug monitoring active pharmaceutical ingredients antibiotics drug degradation decomposition of pharmaceutical products |
| title | Rapid Raman Spectroscopic Analysis of Stress Induced Degradation of the Pharmaceutical Drug Tetracycline |
| title_full | Rapid Raman Spectroscopic Analysis of Stress Induced Degradation of the Pharmaceutical Drug Tetracycline |
| title_fullStr | Rapid Raman Spectroscopic Analysis of Stress Induced Degradation of the Pharmaceutical Drug Tetracycline |
| title_full_unstemmed | Rapid Raman Spectroscopic Analysis of Stress Induced Degradation of the Pharmaceutical Drug Tetracycline |
| title_short | Rapid Raman Spectroscopic Analysis of Stress Induced Degradation of the Pharmaceutical Drug Tetracycline |
| title_sort | rapid raman spectroscopic analysis of stress induced degradation of the pharmaceutical drug tetracycline |
| topic | resonance Raman spectroscopy drug monitoring active pharmaceutical ingredients antibiotics drug degradation decomposition of pharmaceutical products |
| url | https://www.mdpi.com/1420-3049/25/8/1866 |
| work_keys_str_mv | AT christiandomes rapidramanspectroscopicanalysisofstressinduceddegradationofthepharmaceuticaldrugtetracycline AT timeafrosch rapidramanspectroscopicanalysisofstressinduceddegradationofthepharmaceuticaldrugtetracycline AT juergenpopp rapidramanspectroscopicanalysisofstressinduceddegradationofthepharmaceuticaldrugtetracycline AT torstenfrosch rapidramanspectroscopicanalysisofstressinduceddegradationofthepharmaceuticaldrugtetracycline |