Gene-by-environment interactions in urban populations modulate risk phenotypes
Individuals with different genotypes may respond differently to environmental variation. Here, Favé et al. find substantial impacts of different environment exposures on the transcriptome and clinical endophenotypes when controlling for genetic ancestry by analyzing data from ∼1000 individuals from...
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2018-03-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-03202-2 |
| _version_ | 1818992604627337216 |
|---|---|
| author | Marie-Julie Favé Fabien C. Lamaze David Soave Alan Hodgkinson Héloïse Gauvin Vanessa Bruat Jean-Christophe Grenier Elias Gbeha Kimberly Skead Audrey Smargiassi Markey Johnson Youssef Idaghdour Philip Awadalla |
| author_facet | Marie-Julie Favé Fabien C. Lamaze David Soave Alan Hodgkinson Héloïse Gauvin Vanessa Bruat Jean-Christophe Grenier Elias Gbeha Kimberly Skead Audrey Smargiassi Markey Johnson Youssef Idaghdour Philip Awadalla |
| author_sort | Marie-Julie Favé |
| collection | DOAJ |
| description | Individuals with different genotypes may respond differently to environmental variation. Here, Favé et al. find substantial impacts of different environment exposures on the transcriptome and clinical endophenotypes when controlling for genetic ancestry by analyzing data from ∼1000 individuals from a founder population in Quebec. |
| first_indexed | 2024-12-20T20:28:48Z |
| format | Article |
| id | doaj.art-41fc1f6359a849bfb95ac2841971bf1d |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-20T20:28:48Z |
| publishDate | 2018-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-41fc1f6359a849bfb95ac2841971bf1d2022-12-21T19:27:24ZengNature PortfolioNature Communications2041-17232018-03-019111210.1038/s41467-018-03202-2Gene-by-environment interactions in urban populations modulate risk phenotypesMarie-Julie Favé0Fabien C. Lamaze1David Soave2Alan Hodgkinson3Héloïse Gauvin4Vanessa Bruat5Jean-Christophe Grenier6Elias Gbeha7Kimberly Skead8Audrey Smargiassi9Markey Johnson10Youssef Idaghdour11Philip Awadalla12Ontario Institute for Cancer ResearchOntario Institute for Cancer ResearchOntario Institute for Cancer ResearchSainte-Justine Research Center, Faculty of Medicine, University of MontrealSainte-Justine Research Center, Faculty of Medicine, University of MontrealOntario Institute for Cancer ResearchOntario Institute for Cancer ResearchOntario Institute for Cancer ResearchOntario Institute for Cancer ResearchDepartment of Environmental Health and Occupational Health, University of MontrealHealth Canada, Air Health Science DivisionNYU Abu DhabiOntario Institute for Cancer ResearchIndividuals with different genotypes may respond differently to environmental variation. Here, Favé et al. find substantial impacts of different environment exposures on the transcriptome and clinical endophenotypes when controlling for genetic ancestry by analyzing data from ∼1000 individuals from a founder population in Quebec.https://doi.org/10.1038/s41467-018-03202-2 |
| spellingShingle | Marie-Julie Favé Fabien C. Lamaze David Soave Alan Hodgkinson Héloïse Gauvin Vanessa Bruat Jean-Christophe Grenier Elias Gbeha Kimberly Skead Audrey Smargiassi Markey Johnson Youssef Idaghdour Philip Awadalla Gene-by-environment interactions in urban populations modulate risk phenotypes Nature Communications |
| title | Gene-by-environment interactions in urban populations modulate risk phenotypes |
| title_full | Gene-by-environment interactions in urban populations modulate risk phenotypes |
| title_fullStr | Gene-by-environment interactions in urban populations modulate risk phenotypes |
| title_full_unstemmed | Gene-by-environment interactions in urban populations modulate risk phenotypes |
| title_short | Gene-by-environment interactions in urban populations modulate risk phenotypes |
| title_sort | gene by environment interactions in urban populations modulate risk phenotypes |
| url | https://doi.org/10.1038/s41467-018-03202-2 |
| work_keys_str_mv | AT mariejuliefave genebyenvironmentinteractionsinurbanpopulationsmodulateriskphenotypes AT fabienclamaze genebyenvironmentinteractionsinurbanpopulationsmodulateriskphenotypes AT davidsoave genebyenvironmentinteractionsinurbanpopulationsmodulateriskphenotypes AT alanhodgkinson genebyenvironmentinteractionsinurbanpopulationsmodulateriskphenotypes AT heloisegauvin genebyenvironmentinteractionsinurbanpopulationsmodulateriskphenotypes AT vanessabruat genebyenvironmentinteractionsinurbanpopulationsmodulateriskphenotypes AT jeanchristophegrenier genebyenvironmentinteractionsinurbanpopulationsmodulateriskphenotypes AT eliasgbeha genebyenvironmentinteractionsinurbanpopulationsmodulateriskphenotypes AT kimberlyskead genebyenvironmentinteractionsinurbanpopulationsmodulateriskphenotypes AT audreysmargiassi genebyenvironmentinteractionsinurbanpopulationsmodulateriskphenotypes AT markeyjohnson genebyenvironmentinteractionsinurbanpopulationsmodulateriskphenotypes AT youssefidaghdour genebyenvironmentinteractionsinurbanpopulationsmodulateriskphenotypes AT philipawadalla genebyenvironmentinteractionsinurbanpopulationsmodulateriskphenotypes |