The burden of pertussis in older adults: what is the role of vaccination? A systematic literature review
Introduction: Pertussis (whooping cough) is a vaccine-preventable disease; however, neither natural- nor vaccine-induced protection is life-long. Although generally not severe in adults, pertussis can be associated with complications in patients with chronic conditions such as asthma or chronic obst...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2019-05-01
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| Series: | Expert Review of Vaccines |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/14760584.2019.1588727 |
| _version_ | 1797680348846358528 |
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| author | Walid Kandeil Petar Atanasov Diana Avramioti Josephine Fu Nadia Demarteau Xiao Li |
| author_facet | Walid Kandeil Petar Atanasov Diana Avramioti Josephine Fu Nadia Demarteau Xiao Li |
| author_sort | Walid Kandeil |
| collection | DOAJ |
| description | Introduction: Pertussis (whooping cough) is a vaccine-preventable disease; however, neither natural- nor vaccine-induced protection is life-long. Although generally not severe in adults, pertussis can be associated with complications in patients with chronic conditions such as asthma or chronic obstructive pulmonary disease, and can be readily transmitted to more vulnerable populations, including neonates before they complete their primary vaccination. Furthermore, as the global population ages, the health and economic burden of the disease is expected to rise. Areas covered: A systematic literature review was conducted to ascertain the current epidemiological and financial burden of pertussis in older adults and to discuss the potential value of a booster vaccination in this population. Expert commentary: Our review indicates a considerable underestimation of the pertussis burden amongst older adults. Seroprevalence studies consistently demonstrate that the reported incidence may be much lower than the actual incidence. Tetanus toxoid-reduced diphtheria toxoid and acellular pertussis vaccines are immunogenic in older adults, induce high booster responses and are well-tolerated. There is therefore a good rationale for the advocacy of booster pertussis vaccination throughout life to prevent pertussis infection and its transmission, especially in adults aged ≥50 years. |
| first_indexed | 2024-03-11T23:28:42Z |
| format | Article |
| id | doaj.art-41fc4eb0d0394c4aaebd03de200ad76c |
| institution | Directory Open Access Journal |
| issn | 1476-0584 1744-8395 |
| language | English |
| last_indexed | 2024-03-11T23:28:42Z |
| publishDate | 2019-05-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Expert Review of Vaccines |
| spelling | doaj.art-41fc4eb0d0394c4aaebd03de200ad76c2023-09-20T10:18:04ZengTaylor & Francis GroupExpert Review of Vaccines1476-05841744-83952019-05-0118543945510.1080/14760584.2019.15887271588727The burden of pertussis in older adults: what is the role of vaccination? A systematic literature reviewWalid Kandeil0Petar Atanasov1Diana Avramioti2Josephine Fu3Nadia Demarteau4Xiao Li5GSKWork Life - CamdenAmarisWork Life - CamdenGSKGSKIntroduction: Pertussis (whooping cough) is a vaccine-preventable disease; however, neither natural- nor vaccine-induced protection is life-long. Although generally not severe in adults, pertussis can be associated with complications in patients with chronic conditions such as asthma or chronic obstructive pulmonary disease, and can be readily transmitted to more vulnerable populations, including neonates before they complete their primary vaccination. Furthermore, as the global population ages, the health and economic burden of the disease is expected to rise. Areas covered: A systematic literature review was conducted to ascertain the current epidemiological and financial burden of pertussis in older adults and to discuss the potential value of a booster vaccination in this population. Expert commentary: Our review indicates a considerable underestimation of the pertussis burden amongst older adults. Seroprevalence studies consistently demonstrate that the reported incidence may be much lower than the actual incidence. Tetanus toxoid-reduced diphtheria toxoid and acellular pertussis vaccines are immunogenic in older adults, induce high booster responses and are well-tolerated. There is therefore a good rationale for the advocacy of booster pertussis vaccination throughout life to prevent pertussis infection and its transmission, especially in adults aged ≥50 years.http://dx.doi.org/10.1080/14760584.2019.1588727costepidemiologyolder adultspertussisvaccination |
| spellingShingle | Walid Kandeil Petar Atanasov Diana Avramioti Josephine Fu Nadia Demarteau Xiao Li The burden of pertussis in older adults: what is the role of vaccination? A systematic literature review Expert Review of Vaccines cost epidemiology older adults pertussis vaccination |
| title | The burden of pertussis in older adults: what is the role of vaccination? A systematic literature review |
| title_full | The burden of pertussis in older adults: what is the role of vaccination? A systematic literature review |
| title_fullStr | The burden of pertussis in older adults: what is the role of vaccination? A systematic literature review |
| title_full_unstemmed | The burden of pertussis in older adults: what is the role of vaccination? A systematic literature review |
| title_short | The burden of pertussis in older adults: what is the role of vaccination? A systematic literature review |
| title_sort | burden of pertussis in older adults what is the role of vaccination a systematic literature review |
| topic | cost epidemiology older adults pertussis vaccination |
| url | http://dx.doi.org/10.1080/14760584.2019.1588727 |
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