Protective Effect of 1,8-cineole on Learning and Memory Impairment Induced by Cerebral Hypoperfusion in Male Rats
Background and Objectives: Most of the phenomena observed during brain ischemia and reperfusion are associated with damage to the membrane structure. Oxidative stress results in an imbalance between high oxygen consumption and low levels of endogenous antioxidants. It is known that 1,8-cineole is a...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | fas |
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Qom University of Medical Sciences
2020-06-01
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| Series: | Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum |
| Subjects: | |
| Online Access: | http://journal.muq.ac.ir/article-1-2795-en.html |
| _version_ | 1818366943045877760 |
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| author | Mehrdad Farivar Zahra Hooshmandi Mahbubeh Setorki Sabrieh Amini |
| author_facet | Mehrdad Farivar Zahra Hooshmandi Mahbubeh Setorki Sabrieh Amini |
| author_sort | Mehrdad Farivar |
| collection | DOAJ |
| description | Background and Objectives: Most of the phenomena observed during brain ischemia and reperfusion are associated with damage to the membrane structure. Oxidative stress results in an imbalance between high oxygen consumption and low levels of endogenous antioxidants. It is known that 1,8-cineole is a strong antioxidant. The present study was carried out to evaluate the effect of 1,8-cineole on ischemia/reperfusion (I/R)-induced brain injury in rats.
Methods: Wistar adult male rats weighing 250-300 g were divided into five groups of control, normal saline-treated I/R, 5-mg/kg 1,8-cineole-treated I/R, 10-mg/kg 1,8-cineole-treated I/R, and 20-mg/kg 1,8-cineole-treated I/R. The 1,8-cineole was administered through intraperitoneal injection. The cerebral hypoperfusion injury was induced in the adult male rats by occluding the bilateral common carotid arteries for 30 min, followed by 5 days of reperfusion. The data were analyzed by one-way analysis of variance and Tukey's multiple comparison test at a p-value of < 0.05.
Results: The results revealed that the administration of 1,8-cineole significantly increased passive avoidance memory (P<0.05).
Conclusion: Our findings demonstrated the beneficial effects of 1,8-cineole on behavioral impairments after I/R-induced brain injury. |
| first_indexed | 2024-12-13T22:44:11Z |
| format | Article |
| id | doaj.art-420034e66c83415a95ccbfce0537e072 |
| institution | Directory Open Access Journal |
| issn | 1735-7799 2008-1375 |
| language | fas |
| last_indexed | 2024-12-13T22:44:11Z |
| publishDate | 2020-06-01 |
| publisher | Qom University of Medical Sciences |
| record_format | Article |
| series | Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum |
| spelling | doaj.art-420034e66c83415a95ccbfce0537e0722022-12-21T23:28:47ZfasQom University of Medical SciencesMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum1735-77992008-13752020-06-011444047Protective Effect of 1,8-cineole on Learning and Memory Impairment Induced by Cerebral Hypoperfusion in Male RatsMehrdad Farivar0Zahra Hooshmandi1Mahbubeh Setorki2Sabrieh Amini3 Department of Biology, Sanandaj Branch, Islamic Azad University Department of Biology, Sanandaj Branch, Islamic Azad University Department of Biology, Izeh Branch, Islamic Azad University Department of Biology, Sanandaj Branch, Islamic Azad University Background and Objectives: Most of the phenomena observed during brain ischemia and reperfusion are associated with damage to the membrane structure. Oxidative stress results in an imbalance between high oxygen consumption and low levels of endogenous antioxidants. It is known that 1,8-cineole is a strong antioxidant. The present study was carried out to evaluate the effect of 1,8-cineole on ischemia/reperfusion (I/R)-induced brain injury in rats. Methods: Wistar adult male rats weighing 250-300 g were divided into five groups of control, normal saline-treated I/R, 5-mg/kg 1,8-cineole-treated I/R, 10-mg/kg 1,8-cineole-treated I/R, and 20-mg/kg 1,8-cineole-treated I/R. The 1,8-cineole was administered through intraperitoneal injection. The cerebral hypoperfusion injury was induced in the adult male rats by occluding the bilateral common carotid arteries for 30 min, followed by 5 days of reperfusion. The data were analyzed by one-way analysis of variance and Tukey's multiple comparison test at a p-value of < 0.05. Results: The results revealed that the administration of 1,8-cineole significantly increased passive avoidance memory (P<0.05). Conclusion: Our findings demonstrated the beneficial effects of 1,8-cineole on behavioral impairments after I/R-induced brain injury.http://journal.muq.ac.ir/article-1-2795-en.htmlbraineucalyptolhypoxia-ischemiamemory and learning testsrats. |
| spellingShingle | Mehrdad Farivar Zahra Hooshmandi Mahbubeh Setorki Sabrieh Amini Protective Effect of 1,8-cineole on Learning and Memory Impairment Induced by Cerebral Hypoperfusion in Male Rats Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum brain eucalyptol hypoxia-ischemia memory and learning tests rats. |
| title | Protective Effect of 1,8-cineole on Learning and Memory Impairment Induced by Cerebral Hypoperfusion in Male Rats |
| title_full | Protective Effect of 1,8-cineole on Learning and Memory Impairment Induced by Cerebral Hypoperfusion in Male Rats |
| title_fullStr | Protective Effect of 1,8-cineole on Learning and Memory Impairment Induced by Cerebral Hypoperfusion in Male Rats |
| title_full_unstemmed | Protective Effect of 1,8-cineole on Learning and Memory Impairment Induced by Cerebral Hypoperfusion in Male Rats |
| title_short | Protective Effect of 1,8-cineole on Learning and Memory Impairment Induced by Cerebral Hypoperfusion in Male Rats |
| title_sort | protective effect of 1 8 cineole on learning and memory impairment induced by cerebral hypoperfusion in male rats |
| topic | brain eucalyptol hypoxia-ischemia memory and learning tests rats. |
| url | http://journal.muq.ac.ir/article-1-2795-en.html |
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