An Insight Into Intestinal Microbiota of Spontaneously Hypertensive Rats After Valsartan Administration
It has been proven a close relationship between intestinal microbiota and hypertension. Valsartan is a widely used ARB antihypertensive drug; so far, the effect of valsartan on intestinal microbiota remains largely unexplored. Herein, we evaluated the composition, structure and metabolites of intest...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2021-04-01
|
| Series: | Dose-Response |
| Online Access: | https://doi.org/10.1177/15593258211011342 |
| _version_ | 1818779163708882944 |
|---|---|
| author | Ying-Zi Qi Yue-Hua Jiang Ling-Yu Jiang Lin-Lin Shao Xue-Song Yang Chuan-Hua Yang |
| author_facet | Ying-Zi Qi Yue-Hua Jiang Ling-Yu Jiang Lin-Lin Shao Xue-Song Yang Chuan-Hua Yang |
| author_sort | Ying-Zi Qi |
| collection | DOAJ |
| description | It has been proven a close relationship between intestinal microbiota and hypertension. Valsartan is a widely used ARB antihypertensive drug; so far, the effect of valsartan on intestinal microbiota remains largely unexplored. Herein, we evaluated the composition, structure and metabolites of intestinal microbiota of spontaneously hypertensive rats (SHRs) after valsartan administration. In the present study, valsartan administration decreased intestinal microbiota diversity, altered gut microbiota composition, leading to 192 unique OTUs deficiency ( vs WKY rats) and 10 unique OTUs deficiency ( vs SHRs) and did not prove impaired intestinal mucosal barriers. Valsartan decreased the production of isobutyric acid and isovaleric acid in SCFAs. Our findings revealed valsartan administration induced far-reaching and robust changes to the intestinal microbiota of SHRs and provided a better understanding of the relationship between efficacy of valsartan and gastrointestinal tract reaction. |
| first_indexed | 2024-12-18T11:56:15Z |
| format | Article |
| id | doaj.art-4200c32200ee475b9aa2ed01d1a23406 |
| institution | Directory Open Access Journal |
| issn | 1559-3258 |
| language | English |
| last_indexed | 2024-12-18T11:56:15Z |
| publishDate | 2021-04-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Dose-Response |
| spelling | doaj.art-4200c32200ee475b9aa2ed01d1a234062022-12-21T21:09:03ZengSAGE PublishingDose-Response1559-32582021-04-011910.1177/15593258211011342An Insight Into Intestinal Microbiota of Spontaneously Hypertensive Rats After Valsartan AdministrationYing-Zi Qi0Yue-Hua Jiang1Ling-Yu Jiang2Lin-Lin Shao3Xue-Song Yang4Chuan-Hua Yang5 Health College, , Jinan, China Affiliated Hospital of , Jinan, China Affiliated Hospital of , Jinan, China Traditional Chinese Medicine College, , Tianjin, China Affiliated Hospital of , Jinan, China Affiliated Hospital of , Jinan, ChinaIt has been proven a close relationship between intestinal microbiota and hypertension. Valsartan is a widely used ARB antihypertensive drug; so far, the effect of valsartan on intestinal microbiota remains largely unexplored. Herein, we evaluated the composition, structure and metabolites of intestinal microbiota of spontaneously hypertensive rats (SHRs) after valsartan administration. In the present study, valsartan administration decreased intestinal microbiota diversity, altered gut microbiota composition, leading to 192 unique OTUs deficiency ( vs WKY rats) and 10 unique OTUs deficiency ( vs SHRs) and did not prove impaired intestinal mucosal barriers. Valsartan decreased the production of isobutyric acid and isovaleric acid in SCFAs. Our findings revealed valsartan administration induced far-reaching and robust changes to the intestinal microbiota of SHRs and provided a better understanding of the relationship between efficacy of valsartan and gastrointestinal tract reaction.https://doi.org/10.1177/15593258211011342 |
| spellingShingle | Ying-Zi Qi Yue-Hua Jiang Ling-Yu Jiang Lin-Lin Shao Xue-Song Yang Chuan-Hua Yang An Insight Into Intestinal Microbiota of Spontaneously Hypertensive Rats After Valsartan Administration Dose-Response |
| title | An Insight Into Intestinal Microbiota of Spontaneously Hypertensive Rats After Valsartan Administration |
| title_full | An Insight Into Intestinal Microbiota of Spontaneously Hypertensive Rats After Valsartan Administration |
| title_fullStr | An Insight Into Intestinal Microbiota of Spontaneously Hypertensive Rats After Valsartan Administration |
| title_full_unstemmed | An Insight Into Intestinal Microbiota of Spontaneously Hypertensive Rats After Valsartan Administration |
| title_short | An Insight Into Intestinal Microbiota of Spontaneously Hypertensive Rats After Valsartan Administration |
| title_sort | insight into intestinal microbiota of spontaneously hypertensive rats after valsartan administration |
| url | https://doi.org/10.1177/15593258211011342 |
| work_keys_str_mv | AT yingziqi aninsightintointestinalmicrobiotaofspontaneouslyhypertensiveratsaftervalsartanadministration AT yuehuajiang aninsightintointestinalmicrobiotaofspontaneouslyhypertensiveratsaftervalsartanadministration AT lingyujiang aninsightintointestinalmicrobiotaofspontaneouslyhypertensiveratsaftervalsartanadministration AT linlinshao aninsightintointestinalmicrobiotaofspontaneouslyhypertensiveratsaftervalsartanadministration AT xuesongyang aninsightintointestinalmicrobiotaofspontaneouslyhypertensiveratsaftervalsartanadministration AT chuanhuayang aninsightintointestinalmicrobiotaofspontaneouslyhypertensiveratsaftervalsartanadministration AT yingziqi insightintointestinalmicrobiotaofspontaneouslyhypertensiveratsaftervalsartanadministration AT yuehuajiang insightintointestinalmicrobiotaofspontaneouslyhypertensiveratsaftervalsartanadministration AT lingyujiang insightintointestinalmicrobiotaofspontaneouslyhypertensiveratsaftervalsartanadministration AT linlinshao insightintointestinalmicrobiotaofspontaneouslyhypertensiveratsaftervalsartanadministration AT xuesongyang insightintointestinalmicrobiotaofspontaneouslyhypertensiveratsaftervalsartanadministration AT chuanhuayang insightintointestinalmicrobiotaofspontaneouslyhypertensiveratsaftervalsartanadministration |