In vivo and in vitro Evaluation of in situ Gel Formulation of Pemirolast Potassium in Allergic Conjunctivitis
Ting Shen, Zijian Yang Department of Ophthalmology, Ruijin Hospital Affiliated Medical School, Shanghai Jiaotong University, Shanghai, People’s Republic of ChinaCorrespondence: Zijian YangDepartment of Ophthalmology, Ruijin Hospital Affiliated Medical School, Shanghai Jiaotong University,...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2021-05-01
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| Series: | Drug Design, Development and Therapy |
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| Online Access: | https://www.dovepress.com/in-vivo-and-in-vitro-evaluation-of-in-situ-gel-formulation-of-pemirola-peer-reviewed-fulltext-article-DDDT |
| _version_ | 1819070158378893312 |
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| author | Shen T Yang Z |
| author_facet | Shen T Yang Z |
| author_sort | Shen T |
| collection | DOAJ |
| description | Ting Shen, Zijian Yang Department of Ophthalmology, Ruijin Hospital Affiliated Medical School, Shanghai Jiaotong University, Shanghai, People’s Republic of ChinaCorrespondence: Zijian YangDepartment of Ophthalmology, Ruijin Hospital Affiliated Medical School, Shanghai Jiaotong University, No. 197 Second Ruijin Road, Shanghai, People’s Republic of ChinaEmail doctoryzj2020@163.comBackground: To establish a novel delivery system of pemirolast potassium-loaded gellan gum in situ gel in allergic conjunctivitis therapy.Methods: The prepared in situ gels were studied in the following aspects: in vitro gelation, in vitro release, stability, viscosity measurement, in vivo tear kinetics and pharmacodynamics.Results: In this study, the results showed that the viscosity of the in situ gels significantly increased when the preparation was in contact with simulated tear fluid and it also exhibited good stability in a period of three months. In vitro release showed that the release of pemirolast potassium from in situ gels had a good sustained release ability. No ocular damage or abnormal clinical signs to the cornea, iris, or conjunctivae were visible. Consistent with the in vitro studies, pemirolast potassium in situ gels were highly efficient in suppressing the inflammatory symptoms and improving the ocular bioavailability.Conclusion: Pemirolast potassium ocular in situ gels are safe and promising therapeutic alternatives to the existing medications for allergic conjunctivitis therapy.Keywords: pemirolast potassium, gellan gum, in situ gel, allergic conjunctivitis, pharmacodynamic |
| first_indexed | 2024-12-21T17:01:29Z |
| format | Article |
| id | doaj.art-42015690d53444aea9916679cb6de1ff |
| institution | Directory Open Access Journal |
| issn | 1177-8881 |
| language | English |
| last_indexed | 2024-12-21T17:01:29Z |
| publishDate | 2021-05-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Drug Design, Development and Therapy |
| spelling | doaj.art-42015690d53444aea9916679cb6de1ff2022-12-21T18:56:37ZengDove Medical PressDrug Design, Development and Therapy1177-88812021-05-01Volume 152099210764890In vivo and in vitro Evaluation of in situ Gel Formulation of Pemirolast Potassium in Allergic ConjunctivitisShen TYang ZTing Shen, Zijian Yang Department of Ophthalmology, Ruijin Hospital Affiliated Medical School, Shanghai Jiaotong University, Shanghai, People’s Republic of ChinaCorrespondence: Zijian YangDepartment of Ophthalmology, Ruijin Hospital Affiliated Medical School, Shanghai Jiaotong University, No. 197 Second Ruijin Road, Shanghai, People’s Republic of ChinaEmail doctoryzj2020@163.comBackground: To establish a novel delivery system of pemirolast potassium-loaded gellan gum in situ gel in allergic conjunctivitis therapy.Methods: The prepared in situ gels were studied in the following aspects: in vitro gelation, in vitro release, stability, viscosity measurement, in vivo tear kinetics and pharmacodynamics.Results: In this study, the results showed that the viscosity of the in situ gels significantly increased when the preparation was in contact with simulated tear fluid and it also exhibited good stability in a period of three months. In vitro release showed that the release of pemirolast potassium from in situ gels had a good sustained release ability. No ocular damage or abnormal clinical signs to the cornea, iris, or conjunctivae were visible. Consistent with the in vitro studies, pemirolast potassium in situ gels were highly efficient in suppressing the inflammatory symptoms and improving the ocular bioavailability.Conclusion: Pemirolast potassium ocular in situ gels are safe and promising therapeutic alternatives to the existing medications for allergic conjunctivitis therapy.Keywords: pemirolast potassium, gellan gum, in situ gel, allergic conjunctivitis, pharmacodynamichttps://www.dovepress.com/in-vivo-and-in-vitro-evaluation-of-in-situ-gel-formulation-of-pemirola-peer-reviewed-fulltext-article-DDDTpemirolast potassiumgellan gumin situ gelallergic conjunctivitispharmacodynamic |
| spellingShingle | Shen T Yang Z In vivo and in vitro Evaluation of in situ Gel Formulation of Pemirolast Potassium in Allergic Conjunctivitis Drug Design, Development and Therapy pemirolast potassium gellan gum in situ gel allergic conjunctivitis pharmacodynamic |
| title | In vivo and in vitro Evaluation of in situ Gel Formulation of Pemirolast Potassium in Allergic Conjunctivitis |
| title_full | In vivo and in vitro Evaluation of in situ Gel Formulation of Pemirolast Potassium in Allergic Conjunctivitis |
| title_fullStr | In vivo and in vitro Evaluation of in situ Gel Formulation of Pemirolast Potassium in Allergic Conjunctivitis |
| title_full_unstemmed | In vivo and in vitro Evaluation of in situ Gel Formulation of Pemirolast Potassium in Allergic Conjunctivitis |
| title_short | In vivo and in vitro Evaluation of in situ Gel Formulation of Pemirolast Potassium in Allergic Conjunctivitis |
| title_sort | in vivo and in vitro evaluation of in situ gel formulation of pemirolast potassium in allergic conjunctivitis |
| topic | pemirolast potassium gellan gum in situ gel allergic conjunctivitis pharmacodynamic |
| url | https://www.dovepress.com/in-vivo-and-in-vitro-evaluation-of-in-situ-gel-formulation-of-pemirola-peer-reviewed-fulltext-article-DDDT |
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