Vacuolar ATPase Is a Possible Therapeutic Target in Acute Myeloid Leukemia: Focus on Patient Heterogeneity and Treatment Toxicity

Vacuolar ATPase Is a Possible Therapeutic Target in Acute Myeloid Leukemia: Focus on Patient Heterogeneity and Treatment Toxicity

Vacuolar ATPase (V-ATPase) is regarded as a possible target in cancer treatment. It is expressed in primary acute myeloid leukemia cells (AML), but the expression varies between patients and is highest for patients with a favorable prognosis after intensive chemotherapy. We therefore investigated th...

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Bibliographic Details
Main Authors: Sushma Bartaula-Brevik, Calum Leitch, Maria Hernandez-Valladares, Elise Aasebø, Frode S. Berven, Frode Selheim, Annette K. Brenner, Kristin Paulsen Rye, Marie Hagen, Håkon Reikvam, Emmet McCormack, Øystein Bruserud, Tor Henrik Anderson Tvedt
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:Journal of Clinical Medicine
Subjects:
acute myeloid leukemia
vacuolar ATPase
bafilomycin A1
concanamycin
proliferation
apoptosis
Online Access:https://www.mdpi.com/2077-0383/12/17/5546

Internet

https://www.mdpi.com/2077-0383/12/17/5546

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