HHV-6 in Cerebrospinal Fluid in Immunocompetent Children
Background: Human herpes virus-6 (HHV-6) is a ubiquitous virus known as an etiological agent of exanthem subitum. HHV-6-encephalitis in immunocompetent children is a rare complication of the primary infection. There are a lack of data on the prevalence of HHV-6-encephalitis in Russia. The aim of our...
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MDPI AG
2023-09-01
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| Series: | BioMed |
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| Online Access: | https://www.mdpi.com/2673-8430/3/3/34 |
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| author | Mikhail A. Nikolskiy Dmitriy A. Lioznov Evgeniy U. Gorelik Tatyana V. Vishnevskaya |
| author_facet | Mikhail A. Nikolskiy Dmitriy A. Lioznov Evgeniy U. Gorelik Tatyana V. Vishnevskaya |
| author_sort | Mikhail A. Nikolskiy |
| collection | DOAJ |
| description | Background: Human herpes virus-6 (HHV-6) is a ubiquitous virus known as an etiological agent of exanthem subitum. HHV-6-encephalitis in immunocompetent children is a rare complication of the primary infection. There are a lack of data on the prevalence of HHV-6-encephalitis in Russia. The aim of our study was to analyze the prevalence of HHV-6 DNA in the cerebrospinal fluid (CSF) of immunocompetent children with suspected acute meningoencephalitis. Materials and Methods: A total of 712 CSF samples were tested using qualitative PCR over 12 years at N.F. Filatov Children’s City Clinical Hospital No.5, Saint-Petersburg, Russia. Results: HHV-6 DNA was detected in 20 (2.8%) of the samples. Retrospectively, we analyzed the medical records of 15 cases. There were seven boys and eight girls from 1 month to 7 years old; the mean age was 22.3 ± 5.6 months. Most HHV-6 DNA-positive cases were due to the primary form of HHV-6 infection. There were, in total, four cases of HHV-6-meningoencephalitis. All the children had a complete recovery, without neurological deficits or death. Conclusions: HHV-6 encephalitis is a very rare disease in immunocompetent children (four cases among 712 samples over 12 years). Additional studies are needed to develop accurate diagnostic criteria and therapeutic approaches. |
| first_indexed | 2024-03-10T23:01:15Z |
| format | Article |
| id | doaj.art-42047dbf348640348d5cd12f3857b30b |
| institution | Directory Open Access Journal |
| issn | 2673-8430 |
| language | English |
| last_indexed | 2024-03-10T23:01:15Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | BioMed |
| spelling | doaj.art-42047dbf348640348d5cd12f3857b30b2023-11-19T09:39:47ZengMDPI AGBioMed2673-84302023-09-013342043010.3390/biomed3030034HHV-6 in Cerebrospinal Fluid in Immunocompetent ChildrenMikhail A. Nikolskiy0Dmitriy A. Lioznov1Evgeniy U. Gorelik2Tatyana V. Vishnevskaya3Department of Pediatrics, Pavlov First Saint Petersburg State Medical University, 197022 St. Petersburg, RussiaDepartment of Infectious Diseases, Pavlov First Saint Petersburg State Medical University, 197022 St. Petersburg, RussiaInfectious Diseases Department No. 7, N.F. Filatov Children’s City Clinical Hospital No. 5, 192289 St. Petersburg, RussiaInfectious Diseases Department No. 7, N.F. Filatov Children’s City Clinical Hospital No. 5, 192289 St. Petersburg, RussiaBackground: Human herpes virus-6 (HHV-6) is a ubiquitous virus known as an etiological agent of exanthem subitum. HHV-6-encephalitis in immunocompetent children is a rare complication of the primary infection. There are a lack of data on the prevalence of HHV-6-encephalitis in Russia. The aim of our study was to analyze the prevalence of HHV-6 DNA in the cerebrospinal fluid (CSF) of immunocompetent children with suspected acute meningoencephalitis. Materials and Methods: A total of 712 CSF samples were tested using qualitative PCR over 12 years at N.F. Filatov Children’s City Clinical Hospital No.5, Saint-Petersburg, Russia. Results: HHV-6 DNA was detected in 20 (2.8%) of the samples. Retrospectively, we analyzed the medical records of 15 cases. There were seven boys and eight girls from 1 month to 7 years old; the mean age was 22.3 ± 5.6 months. Most HHV-6 DNA-positive cases were due to the primary form of HHV-6 infection. There were, in total, four cases of HHV-6-meningoencephalitis. All the children had a complete recovery, without neurological deficits or death. Conclusions: HHV-6 encephalitis is a very rare disease in immunocompetent children (four cases among 712 samples over 12 years). Additional studies are needed to develop accurate diagnostic criteria and therapeutic approaches.https://www.mdpi.com/2673-8430/3/3/34HHV-6CSFencephalitisimmunocompetent children |
| spellingShingle | Mikhail A. Nikolskiy Dmitriy A. Lioznov Evgeniy U. Gorelik Tatyana V. Vishnevskaya HHV-6 in Cerebrospinal Fluid in Immunocompetent Children BioMed HHV-6 CSF encephalitis immunocompetent children |
| title | HHV-6 in Cerebrospinal Fluid in Immunocompetent Children |
| title_full | HHV-6 in Cerebrospinal Fluid in Immunocompetent Children |
| title_fullStr | HHV-6 in Cerebrospinal Fluid in Immunocompetent Children |
| title_full_unstemmed | HHV-6 in Cerebrospinal Fluid in Immunocompetent Children |
| title_short | HHV-6 in Cerebrospinal Fluid in Immunocompetent Children |
| title_sort | hhv 6 in cerebrospinal fluid in immunocompetent children |
| topic | HHV-6 CSF encephalitis immunocompetent children |
| url | https://www.mdpi.com/2673-8430/3/3/34 |
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