REGIONAL ASPECTS OF THE GENE POLYMORPHISM VЕGFR2 WITH CORONARY ATHEROSCLEROSIS IN ACUTE CORONARY SYNDROME
Aim. Evaluation of the associations of allele variant of gene VЕGFR2 rs2305948 with atherosclerotic lesion of coronary arteries in acute coronary syndrome (ACS) patients in the North (Surgut city) and big cities of the Siberian Federal District (SFD) (Novosibirsk, Irkutsk, Kemerovo).Mater...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
«FIRMA «SILICEA» LLC
2017-11-01
|
| Series: | Российский кардиологический журнал |
| Subjects: | |
| Online Access: | https://russjcardiol.elpub.ru/jour/article/view/2395 |
| _version_ | 1797856877908852736 |
|---|---|
| author | K. Yu. Nikolaev I. A. Urvantseva К. Yu. Batueva К. A. Apartsin А. V. Gorokhova V. I. Ganyukov N. А. Kochergin Е. M. Zelenskaya G. I. Lifshits |
| author_facet | K. Yu. Nikolaev I. A. Urvantseva К. Yu. Batueva К. A. Apartsin А. V. Gorokhova V. I. Ganyukov N. А. Kochergin Е. M. Zelenskaya G. I. Lifshits |
| author_sort | K. Yu. Nikolaev |
| collection | DOAJ |
| description | Aim. Evaluation of the associations of allele variant of gene VЕGFR2 rs2305948 with atherosclerotic lesion of coronary arteries in acute coronary syndrome (ACS) patients in the North (Surgut city) and big cities of the Siberian Federal District (SFD) (Novosibirsk, Irkutsk, Kemerovo).Material and methods. Totally, 258 consecutive ACS patients investigated, at admission to cardiological in-patient clinics of big cities of the North (Surgut, 78 patients) and SFD (180 patients). All patients underwent coronary arteriography and genetic test (the allele variant assessment VЕGFR2 rs2305948).Results. In Surgut patients the allele variant VЕGFR2*CC is directly linked with the lesion of proximal and intermediate part of three main arteries >70% (PTA) (χ2=4,68; p=0,031), PTA and left main stem stenosis >50% (χ2=7,02; p=0,008), and in patients from SFD VЕGFR2 *CT + *TT is directly associated with hypercholesterolemia (HC) (χ2=8,53; p=0,003). Combination of allele variant VЕGFR2*CC with HC directly influences PTA of stem stenosis >50% in ACS patients in Surgut (Exp (B) =4,441; 95% CI (1,351; 14,601); p=0,014). Combination of allele variant VЕGFR2*CC with HC directly influences stenosis >70% existence in at least three coronary arteries, in Surgut patients (Exp (B): 3,697; 95% CI (1,304; 10,486);p=0,014), as in SFD patients exp (B): 4,460; 95% CI (1,306; 15,236); p=0,017).Conclusion. Allele variant VЕGFR2*СС does directly influence the existence of coronary atherosclerosis of various grade severity in patients with ACS in the North, and if combined with VЕGFR2*СС and HC is also a risk factor for coronary atherosclerosis not only in the North but in SFD cities as well. |
| first_indexed | 2024-04-09T20:47:39Z |
| format | Article |
| id | doaj.art-420642152a444932933adde404f4b236 |
| institution | Directory Open Access Journal |
| issn | 1560-4071 2618-7620 |
| language | Russian |
| last_indexed | 2024-04-09T20:47:39Z |
| publishDate | 2017-11-01 |
| publisher | «FIRMA «SILICEA» LLC |
| record_format | Article |
| series | Российский кардиологический журнал |
| spelling | doaj.art-420642152a444932933adde404f4b2362023-03-29T21:23:29Zrus«FIRMA «SILICEA» LLCРоссийский кардиологический журнал1560-40712618-76202017-11-01010616510.15829/1560-4071-2017-10-61-652233REGIONAL ASPECTS OF THE GENE POLYMORPHISM VЕGFR2 WITH CORONARY ATHEROSCLEROSIS IN ACUTE CORONARY SYNDROMEK. Yu. Nikolaev0I. A. Urvantseva1К. Yu. Batueva2К. A. Apartsin3А. V. Gorokhova4V. I. Ganyukov5N. А. Kochergin6Е. M. Zelenskaya7G. I. Lifshits8SRI of therapy and Prevention Medicine — branch of SD RAS; Novosibirsk State UniversitySurgut State UniversitySurgut State UniversityIrkutsk scientific Center of SD RAS; Irkutskaya Oblast Clinical Hospital of the “Sign of Honour” AwardIrkutskaya Oblast Clinical Hospital of the “Sign of Honour” AwardResearch Institute for Complex Issues of Cardiovascular DiseasesResearch Institute for Complex Issues of Cardiovascular DiseasesInstitute of Chemical Biology and Fundamental Medicine of SD RASInstitute of Chemical Biology and Fundamental Medicine of SD RAS; Novosibirsk State UniversityAim. Evaluation of the associations of allele variant of gene VЕGFR2 rs2305948 with atherosclerotic lesion of coronary arteries in acute coronary syndrome (ACS) patients in the North (Surgut city) and big cities of the Siberian Federal District (SFD) (Novosibirsk, Irkutsk, Kemerovo).Material and methods. Totally, 258 consecutive ACS patients investigated, at admission to cardiological in-patient clinics of big cities of the North (Surgut, 78 patients) and SFD (180 patients). All patients underwent coronary arteriography and genetic test (the allele variant assessment VЕGFR2 rs2305948).Results. In Surgut patients the allele variant VЕGFR2*CC is directly linked with the lesion of proximal and intermediate part of three main arteries >70% (PTA) (χ2=4,68; p=0,031), PTA and left main stem stenosis >50% (χ2=7,02; p=0,008), and in patients from SFD VЕGFR2 *CT + *TT is directly associated with hypercholesterolemia (HC) (χ2=8,53; p=0,003). Combination of allele variant VЕGFR2*CC with HC directly influences PTA of stem stenosis >50% in ACS patients in Surgut (Exp (B) =4,441; 95% CI (1,351; 14,601); p=0,014). Combination of allele variant VЕGFR2*CC with HC directly influences stenosis >70% existence in at least three coronary arteries, in Surgut patients (Exp (B): 3,697; 95% CI (1,304; 10,486);p=0,014), as in SFD patients exp (B): 4,460; 95% CI (1,306; 15,236); p=0,017).Conclusion. Allele variant VЕGFR2*СС does directly influence the existence of coronary atherosclerosis of various grade severity in patients with ACS in the North, and if combined with VЕGFR2*СС and HC is also a risk factor for coronary atherosclerosis not only in the North but in SFD cities as well.https://russjcardiol.elpub.ru/jour/article/view/2395acute coronary syndromecoronary atherosclerosisallele variants of vеgfr2hypercholesterolemiathe north |
| spellingShingle | K. Yu. Nikolaev I. A. Urvantseva К. Yu. Batueva К. A. Apartsin А. V. Gorokhova V. I. Ganyukov N. А. Kochergin Е. M. Zelenskaya G. I. Lifshits REGIONAL ASPECTS OF THE GENE POLYMORPHISM VЕGFR2 WITH CORONARY ATHEROSCLEROSIS IN ACUTE CORONARY SYNDROME Российский кардиологический журнал acute coronary syndrome coronary atherosclerosis allele variants of vеgfr2 hypercholesterolemia the north |
| title | REGIONAL ASPECTS OF THE GENE POLYMORPHISM VЕGFR2 WITH CORONARY ATHEROSCLEROSIS IN ACUTE CORONARY SYNDROME |
| title_full | REGIONAL ASPECTS OF THE GENE POLYMORPHISM VЕGFR2 WITH CORONARY ATHEROSCLEROSIS IN ACUTE CORONARY SYNDROME |
| title_fullStr | REGIONAL ASPECTS OF THE GENE POLYMORPHISM VЕGFR2 WITH CORONARY ATHEROSCLEROSIS IN ACUTE CORONARY SYNDROME |
| title_full_unstemmed | REGIONAL ASPECTS OF THE GENE POLYMORPHISM VЕGFR2 WITH CORONARY ATHEROSCLEROSIS IN ACUTE CORONARY SYNDROME |
| title_short | REGIONAL ASPECTS OF THE GENE POLYMORPHISM VЕGFR2 WITH CORONARY ATHEROSCLEROSIS IN ACUTE CORONARY SYNDROME |
| title_sort | regional aspects of the gene polymorphism vеgfr2 with coronary atherosclerosis in acute coronary syndrome |
| topic | acute coronary syndrome coronary atherosclerosis allele variants of vеgfr2 hypercholesterolemia the north |
| url | https://russjcardiol.elpub.ru/jour/article/view/2395 |
| work_keys_str_mv | AT kyunikolaev regionalaspectsofthegenepolymorphismvegfr2withcoronaryatherosclerosisinacutecoronarysyndrome AT iaurvantseva regionalaspectsofthegenepolymorphismvegfr2withcoronaryatherosclerosisinacutecoronarysyndrome AT kyubatueva regionalaspectsofthegenepolymorphismvegfr2withcoronaryatherosclerosisinacutecoronarysyndrome AT kaapartsin regionalaspectsofthegenepolymorphismvegfr2withcoronaryatherosclerosisinacutecoronarysyndrome AT avgorokhova regionalaspectsofthegenepolymorphismvegfr2withcoronaryatherosclerosisinacutecoronarysyndrome AT viganyukov regionalaspectsofthegenepolymorphismvegfr2withcoronaryatherosclerosisinacutecoronarysyndrome AT nakochergin regionalaspectsofthegenepolymorphismvegfr2withcoronaryatherosclerosisinacutecoronarysyndrome AT emzelenskaya regionalaspectsofthegenepolymorphismvegfr2withcoronaryatherosclerosisinacutecoronarysyndrome AT gilifshits regionalaspectsofthegenepolymorphismvegfr2withcoronaryatherosclerosisinacutecoronarysyndrome |