H-PVA Cross-Linking Mechanism Prepared By Freeze-Thaw And Annealing: Optimizing Gel Fraction And Swelling
PVA has attracted attention as a material in the formation of hydrogels for drug release media. Crosslinking is one of the keys to hydrogel formation. Gel fraction, swelling ratio, and degree of crystallinity are parameters used to determine the enhancement of crosslinking and the formation of mecha...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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EDP Sciences
2024-01-01
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| Series: | E3S Web of Conferences |
| Online Access: | https://www.e3s-conferences.org/articles/e3sconf/pdf/2024/33/e3sconf_isac-iccme2023_08008.pdf |
| _version_ | 1797248935405813760 |
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| author | Tsaniatri Dhiya’ Acfira Mulia Kamarza Krisanti Elsa Anisa |
| author_facet | Tsaniatri Dhiya’ Acfira Mulia Kamarza Krisanti Elsa Anisa |
| author_sort | Tsaniatri Dhiya’ Acfira |
| collection | DOAJ |
| description | PVA has attracted attention as a material in the formation of hydrogels for drug release media. Crosslinking is one of the keys to hydrogel formation. Gel fraction, swelling ratio, and degree of crystallinity are parameters used to determine the enhancement of crosslinking and the formation of mechanical properties of hydrogels. H-PVA was synthesized through freeze-thaw and annealing processes and optimized by Box-Behnken design. Analysis of the degree of crystallinity revealed that the freeze-thaw and annealing processes formed and increased crosslinking. This is supported by data from the gel fraction analysis, which indicates that the number of crosslinks increases and the swelling ratio decreases, indicating that the hydrogel structure is strong enough to withstand water absorption. The results of the design of the experiment (DOE) showed that simultaneously the model was able to explain the presence of crosslinks formed in H-PVA, as seen from the p-value >0.0001 and the statistical test results R2 = 0.99 (close to 1). Optimal conditions were found at a PVA concentration of 18.972 (%w/v), a freeze-thaw cycle of three times, and an annealing temperature of 92 °C. |
| first_indexed | 2024-04-24T20:22:29Z |
| format | Article |
| id | doaj.art-420862a6aa894514a1db4cac623d0071 |
| institution | Directory Open Access Journal |
| issn | 2267-1242 |
| language | English |
| last_indexed | 2024-04-24T20:22:29Z |
| publishDate | 2024-01-01 |
| publisher | EDP Sciences |
| record_format | Article |
| series | E3S Web of Conferences |
| spelling | doaj.art-420862a6aa894514a1db4cac623d00712024-03-22T07:56:07ZengEDP SciencesE3S Web of Conferences2267-12422024-01-015030800810.1051/e3sconf/202450308008e3sconf_isac-iccme2023_08008H-PVA Cross-Linking Mechanism Prepared By Freeze-Thaw And Annealing: Optimizing Gel Fraction And SwellingTsaniatri Dhiya’ Acfira0Mulia Kamarza1Krisanti Elsa Anisa2Department of Chemical Engineering, Faculty of Engineering, Universitas IndonesiaDepartment of Chemical Engineering, Faculty of Engineering, Universitas IndonesiaDepartment of Chemical Engineering, Faculty of Engineering, Universitas IndonesiaPVA has attracted attention as a material in the formation of hydrogels for drug release media. Crosslinking is one of the keys to hydrogel formation. Gel fraction, swelling ratio, and degree of crystallinity are parameters used to determine the enhancement of crosslinking and the formation of mechanical properties of hydrogels. H-PVA was synthesized through freeze-thaw and annealing processes and optimized by Box-Behnken design. Analysis of the degree of crystallinity revealed that the freeze-thaw and annealing processes formed and increased crosslinking. This is supported by data from the gel fraction analysis, which indicates that the number of crosslinks increases and the swelling ratio decreases, indicating that the hydrogel structure is strong enough to withstand water absorption. The results of the design of the experiment (DOE) showed that simultaneously the model was able to explain the presence of crosslinks formed in H-PVA, as seen from the p-value >0.0001 and the statistical test results R2 = 0.99 (close to 1). Optimal conditions were found at a PVA concentration of 18.972 (%w/v), a freeze-thaw cycle of three times, and an annealing temperature of 92 °C.https://www.e3s-conferences.org/articles/e3sconf/pdf/2024/33/e3sconf_isac-iccme2023_08008.pdf |
| spellingShingle | Tsaniatri Dhiya’ Acfira Mulia Kamarza Krisanti Elsa Anisa H-PVA Cross-Linking Mechanism Prepared By Freeze-Thaw And Annealing: Optimizing Gel Fraction And Swelling E3S Web of Conferences |
| title | H-PVA Cross-Linking Mechanism Prepared By Freeze-Thaw And Annealing: Optimizing Gel Fraction And Swelling |
| title_full | H-PVA Cross-Linking Mechanism Prepared By Freeze-Thaw And Annealing: Optimizing Gel Fraction And Swelling |
| title_fullStr | H-PVA Cross-Linking Mechanism Prepared By Freeze-Thaw And Annealing: Optimizing Gel Fraction And Swelling |
| title_full_unstemmed | H-PVA Cross-Linking Mechanism Prepared By Freeze-Thaw And Annealing: Optimizing Gel Fraction And Swelling |
| title_short | H-PVA Cross-Linking Mechanism Prepared By Freeze-Thaw And Annealing: Optimizing Gel Fraction And Swelling |
| title_sort | h pva cross linking mechanism prepared by freeze thaw and annealing optimizing gel fraction and swelling |
| url | https://www.e3s-conferences.org/articles/e3sconf/pdf/2024/33/e3sconf_isac-iccme2023_08008.pdf |
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