Read the clonotype: Next-generation sequencing-based lymphocyte clonality analysis and perspectives for application in pathology

Read the clonotype: Next-generation sequencing-based lymphocyte clonality analysis and perspectives for application in pathology

Clonality assessment using the unique rearrangements of immunoglobulin (IG) and T-cell receptor (TR) genes in lymphocytes is a widely applied supplementary test for the diagnosis of B-cell and T-cell lymphoma. To enable a more sensitive detection and a more precise comparison of clones compared with...

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Bibliographic Details
Main Authors: Patricia J. T. A. Groenen, Michiel van den Brand, Leonie I. Kroeze, Avital L. Amir, Konnie M. Hebeda
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Oncology
Subjects:
immunoglobulin E
T-cell receptor
gene rearrangement
clonality assessment
NGS
pathology
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2023.1107171/full

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