Establishment of muscle mass-based indications for the cystatin C test in renal function evaluation
BackgroundWe aimed to suggest muscle mass-based criteria for using of the cystatin C test for the accurate estimated glomerular filtration rate (eGFR).Materials and methodsWe recruited 138 Korean subjects and evaluated eGFRcr (derived from Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI)...
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-11-01
|
| Series: | Frontiers in Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2022.1021936/full |
| _version_ | 1811322035124568064 |
|---|---|
| author | Jisook Yim Jisook Yim Nak-Hoon Son Kyoung Min Kim Dukyong Yoon Yonggeun Cho Taeyoung Kyong Ja-Young Moon Tae Im Yi Sang-Guk Lee Yongjung Park Jung Joo Lee Kyung-Ah Kim Jung Eun Lee Jeong-Ho Kim Jeong-Ho Kim |
| author_facet | Jisook Yim Jisook Yim Nak-Hoon Son Kyoung Min Kim Dukyong Yoon Yonggeun Cho Taeyoung Kyong Ja-Young Moon Tae Im Yi Sang-Guk Lee Yongjung Park Jung Joo Lee Kyung-Ah Kim Jung Eun Lee Jeong-Ho Kim Jeong-Ho Kim |
| author_sort | Jisook Yim |
| collection | DOAJ |
| description | BackgroundWe aimed to suggest muscle mass-based criteria for using of the cystatin C test for the accurate estimated glomerular filtration rate (eGFR).Materials and methodsWe recruited 138 Korean subjects and evaluated eGFRcr (derived from Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) based on creatinine) was compared to eGFRcys based on cystatin C as the reference value. The skeletal muscle mass index (SMI) by bioelectrical impedance analysis (BIA) was used as representative of muscle mass. Calf circumference (CC) was also evaluated. We defined the patients by eGFRcr as those with values of eGFRcr ≥ 60 mL/min/1.73 m2 but eGFRcys < 60 mL/min/1.73 m2 as the detection of hidden renal impairment (DHRI). Cut-off values were determined based on muscle mass for the cases of DHRI suggesting the criteria of cystatin C test in renal function evaluation.ResultsWe confirmed significant negative correlation between %difference of eGFRcr from eGFRcys and SMI (r, −0.592 for male, −0.484 for female) or CC (r, −0.646 for male, −0.351 for female). SMI of 7.3 kg/m2 for males and 5.7 kg/m2 for females were suggested to be significant cutoffs for indication of cystatin C test. We also suggested CC would be valuable for cystatin C indication.ConclusionWe suggested the muscle mass-based objective criteria relating to SMI and CC that would indicate the use of cystatin C to evaluate renal function test in sarcopenic cases. Our results highlight the importance of muscle mass-based selection of renal function. |
| first_indexed | 2024-04-13T13:28:07Z |
| format | Article |
| id | doaj.art-420a3743925f42969242432c964ce8b5 |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-04-13T13:28:07Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-420a3743925f42969242432c964ce8b52022-12-22T02:45:04ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2022-11-01910.3389/fmed.2022.10219361021936Establishment of muscle mass-based indications for the cystatin C test in renal function evaluationJisook Yim0Jisook Yim1Nak-Hoon Son2Kyoung Min Kim3Dukyong Yoon4Yonggeun Cho5Taeyoung Kyong6Ja-Young Moon7Tae Im Yi8Sang-Guk Lee9Yongjung Park10Jung Joo Lee11Kyung-Ah Kim12Jung Eun Lee13Jeong-Ho Kim14Jeong-Ho Kim15Department of Laboratory Medicine, Yonsei University College of Medicine, Seoul, South KoreaDepartment of Laboratory Medicine, College of Medicine, The Catholic University of Korea, Seoul, South KoreaDepartment of Statistics, Keimyung University, Daegu, South KoreaDivision of Endocrinology, Department of Internal Medicine, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin, South KoreaDepartment of Biomedical Systems Informatics, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin, South KoreaDepartment of Laboratory Medicine, Hallym University Sacred Heart Hospital, Anyang, South KoreaDepartment of Hospital Medicine, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin, South KoreaDepartment of Hospital Medicine, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin, South KoreaDepartment of Rehabilitation Medicine, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin, South KoreaDepartment of Laboratory Medicine, Yonsei University College of Medicine, Seoul, South KoreaDepartment of Laboratory Medicine, Yonsei University College of Medicine, Seoul, South KoreaDepartment of Nutrition, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin, South Korea0Department of Laboratory Medicine, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin, South Korea1Division of Nephrology, Department of Internal Medicine, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin, South KoreaDepartment of Laboratory Medicine, Yonsei University College of Medicine, Seoul, South Korea0Department of Laboratory Medicine, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin, South KoreaBackgroundWe aimed to suggest muscle mass-based criteria for using of the cystatin C test for the accurate estimated glomerular filtration rate (eGFR).Materials and methodsWe recruited 138 Korean subjects and evaluated eGFRcr (derived from Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) based on creatinine) was compared to eGFRcys based on cystatin C as the reference value. The skeletal muscle mass index (SMI) by bioelectrical impedance analysis (BIA) was used as representative of muscle mass. Calf circumference (CC) was also evaluated. We defined the patients by eGFRcr as those with values of eGFRcr ≥ 60 mL/min/1.73 m2 but eGFRcys < 60 mL/min/1.73 m2 as the detection of hidden renal impairment (DHRI). Cut-off values were determined based on muscle mass for the cases of DHRI suggesting the criteria of cystatin C test in renal function evaluation.ResultsWe confirmed significant negative correlation between %difference of eGFRcr from eGFRcys and SMI (r, −0.592 for male, −0.484 for female) or CC (r, −0.646 for male, −0.351 for female). SMI of 7.3 kg/m2 for males and 5.7 kg/m2 for females were suggested to be significant cutoffs for indication of cystatin C test. We also suggested CC would be valuable for cystatin C indication.ConclusionWe suggested the muscle mass-based objective criteria relating to SMI and CC that would indicate the use of cystatin C to evaluate renal function test in sarcopenic cases. Our results highlight the importance of muscle mass-based selection of renal function.https://www.frontiersin.org/articles/10.3389/fmed.2022.1021936/fullbioelectrical impedance analysis (BIA)creatinine (Cr)cystatin C (CysC)estimated glomerular filtration rate (eGFR)muscle masskidney function tests |
| spellingShingle | Jisook Yim Jisook Yim Nak-Hoon Son Kyoung Min Kim Dukyong Yoon Yonggeun Cho Taeyoung Kyong Ja-Young Moon Tae Im Yi Sang-Guk Lee Yongjung Park Jung Joo Lee Kyung-Ah Kim Jung Eun Lee Jeong-Ho Kim Jeong-Ho Kim Establishment of muscle mass-based indications for the cystatin C test in renal function evaluation Frontiers in Medicine bioelectrical impedance analysis (BIA) creatinine (Cr) cystatin C (CysC) estimated glomerular filtration rate (eGFR) muscle mass kidney function tests |
| title | Establishment of muscle mass-based indications for the cystatin C test in renal function evaluation |
| title_full | Establishment of muscle mass-based indications for the cystatin C test in renal function evaluation |
| title_fullStr | Establishment of muscle mass-based indications for the cystatin C test in renal function evaluation |
| title_full_unstemmed | Establishment of muscle mass-based indications for the cystatin C test in renal function evaluation |
| title_short | Establishment of muscle mass-based indications for the cystatin C test in renal function evaluation |
| title_sort | establishment of muscle mass based indications for the cystatin c test in renal function evaluation |
| topic | bioelectrical impedance analysis (BIA) creatinine (Cr) cystatin C (CysC) estimated glomerular filtration rate (eGFR) muscle mass kidney function tests |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2022.1021936/full |
| work_keys_str_mv | AT jisookyim establishmentofmusclemassbasedindicationsforthecystatinctestinrenalfunctionevaluation AT jisookyim establishmentofmusclemassbasedindicationsforthecystatinctestinrenalfunctionevaluation AT nakhoonson establishmentofmusclemassbasedindicationsforthecystatinctestinrenalfunctionevaluation AT kyoungminkim establishmentofmusclemassbasedindicationsforthecystatinctestinrenalfunctionevaluation AT dukyongyoon establishmentofmusclemassbasedindicationsforthecystatinctestinrenalfunctionevaluation AT yonggeuncho establishmentofmusclemassbasedindicationsforthecystatinctestinrenalfunctionevaluation AT taeyoungkyong establishmentofmusclemassbasedindicationsforthecystatinctestinrenalfunctionevaluation AT jayoungmoon establishmentofmusclemassbasedindicationsforthecystatinctestinrenalfunctionevaluation AT taeimyi establishmentofmusclemassbasedindicationsforthecystatinctestinrenalfunctionevaluation AT sangguklee establishmentofmusclemassbasedindicationsforthecystatinctestinrenalfunctionevaluation AT yongjungpark establishmentofmusclemassbasedindicationsforthecystatinctestinrenalfunctionevaluation AT jungjoolee establishmentofmusclemassbasedindicationsforthecystatinctestinrenalfunctionevaluation AT kyungahkim establishmentofmusclemassbasedindicationsforthecystatinctestinrenalfunctionevaluation AT jungeunlee establishmentofmusclemassbasedindicationsforthecystatinctestinrenalfunctionevaluation AT jeonghokim establishmentofmusclemassbasedindicationsforthecystatinctestinrenalfunctionevaluation AT jeonghokim establishmentofmusclemassbasedindicationsforthecystatinctestinrenalfunctionevaluation |