Hydrogen Sulfide—Clues from Evolution and Implication for Neonatal Respiratory Diseases
Reactive oxygen species (ROS) have been the focus of redox research in the realm of oxidative neonatal respiratory diseases such as bronchopulmonary dysplasia (BPD). Over the years, nitric oxide (NO) and carbon monoxide (CO) have been identified as important gaseous signaling molecules involved in m...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-03-01
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| Series: | Children |
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| Online Access: | https://www.mdpi.com/2227-9067/8/3/213 |
| _version_ | 1797541825145208832 |
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| author | Abhrajit Ganguly Gaston Ofman Peter F Vitiello |
| author_facet | Abhrajit Ganguly Gaston Ofman Peter F Vitiello |
| author_sort | Abhrajit Ganguly |
| collection | DOAJ |
| description | Reactive oxygen species (ROS) have been the focus of redox research in the realm of oxidative neonatal respiratory diseases such as bronchopulmonary dysplasia (BPD). Over the years, nitric oxide (NO) and carbon monoxide (CO) have been identified as important gaseous signaling molecules involved in modulating the redox homeostasis in the developing lung. While animal data targeting aspects of these redox pathways have been promising in treating and/or preventing experimental models of neonatal lung disease, none are particularly effective in human neonatal clinical trials. In recent years, hydrogen sulfide (H<sub>2</sub>S) has emerged as a novel gasotransmitter involved in a magnitude of cellular signaling pathways and functions. The importance of H<sub>2</sub>S signaling may lie in the fact that early life-forms evolved in a nearly anoxic, sulfur-rich environment and were dependent on H<sub>2</sub>S for energy. Recent studies have demonstrated an important role of H<sub>2</sub>S and its synthesizing enzymes in lung development, which normally takes place in a relatively hypoxic intrauterine environment. In this review, we look at clues from evolution and explore the important role that the H<sub>2</sub>S signaling pathway may play in oxidative neonatal respiratory diseases and discuss future opportunities to explore this phenomenon in the context of neonatal chronic lung disease. |
| first_indexed | 2024-03-10T13:21:08Z |
| format | Article |
| id | doaj.art-420ae78f13aa4eb1ba3ef25604d5740c |
| institution | Directory Open Access Journal |
| issn | 2227-9067 |
| language | English |
| last_indexed | 2024-03-10T13:21:08Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Children |
| spelling | doaj.art-420ae78f13aa4eb1ba3ef25604d5740c2023-11-21T10:00:18ZengMDPI AGChildren2227-90672021-03-018321310.3390/children8030213Hydrogen Sulfide—Clues from Evolution and Implication for Neonatal Respiratory DiseasesAbhrajit Ganguly0Gaston Ofman1Peter F Vitiello2Center for Pregnancy and Newborn Research, Department of Pediatrics, Section of Neonatal-Perinatal Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USACenter for Pregnancy and Newborn Research, Department of Pediatrics, Section of Neonatal-Perinatal Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USACenter for Pregnancy and Newborn Research, Department of Pediatrics, Section of Neonatal-Perinatal Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USAReactive oxygen species (ROS) have been the focus of redox research in the realm of oxidative neonatal respiratory diseases such as bronchopulmonary dysplasia (BPD). Over the years, nitric oxide (NO) and carbon monoxide (CO) have been identified as important gaseous signaling molecules involved in modulating the redox homeostasis in the developing lung. While animal data targeting aspects of these redox pathways have been promising in treating and/or preventing experimental models of neonatal lung disease, none are particularly effective in human neonatal clinical trials. In recent years, hydrogen sulfide (H<sub>2</sub>S) has emerged as a novel gasotransmitter involved in a magnitude of cellular signaling pathways and functions. The importance of H<sub>2</sub>S signaling may lie in the fact that early life-forms evolved in a nearly anoxic, sulfur-rich environment and were dependent on H<sub>2</sub>S for energy. Recent studies have demonstrated an important role of H<sub>2</sub>S and its synthesizing enzymes in lung development, which normally takes place in a relatively hypoxic intrauterine environment. In this review, we look at clues from evolution and explore the important role that the H<sub>2</sub>S signaling pathway may play in oxidative neonatal respiratory diseases and discuss future opportunities to explore this phenomenon in the context of neonatal chronic lung disease.https://www.mdpi.com/2227-9067/8/3/213hydrogen sulfidebronchopulmonary dysplasiaprematurityneonatal lung diseases |
| spellingShingle | Abhrajit Ganguly Gaston Ofman Peter F Vitiello Hydrogen Sulfide—Clues from Evolution and Implication for Neonatal Respiratory Diseases Children hydrogen sulfide bronchopulmonary dysplasia prematurity neonatal lung diseases |
| title | Hydrogen Sulfide—Clues from Evolution and Implication for Neonatal Respiratory Diseases |
| title_full | Hydrogen Sulfide—Clues from Evolution and Implication for Neonatal Respiratory Diseases |
| title_fullStr | Hydrogen Sulfide—Clues from Evolution and Implication for Neonatal Respiratory Diseases |
| title_full_unstemmed | Hydrogen Sulfide—Clues from Evolution and Implication for Neonatal Respiratory Diseases |
| title_short | Hydrogen Sulfide—Clues from Evolution and Implication for Neonatal Respiratory Diseases |
| title_sort | hydrogen sulfide clues from evolution and implication for neonatal respiratory diseases |
| topic | hydrogen sulfide bronchopulmonary dysplasia prematurity neonatal lung diseases |
| url | https://www.mdpi.com/2227-9067/8/3/213 |
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