Olives and olive oil are sources of electrophilic fatty acid nitroalkenes.
Extra virgin olive oil (EVOO) and olives, key sources of unsaturated fatty acids in the Mediterranean diet, provide health benefits to humans. Nitric oxide (•NO) and nitrite (NO2 (-))-dependent reactions of unsaturated fatty acids yield electrophilic nitroalkene derivatives (NO2-FA) that manifest sa...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3891761?pdf=render |
| _version_ | 1818441645673152512 |
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| author | Marco Fazzari Andrés Trostchansky Francisco J Schopfer Sonia R Salvatore Beatriz Sánchez-Calvo Dario Vitturi Raquel Valderrama Juan B Barroso Rafael Radi Bruce A Freeman Homero Rubbo |
| author_facet | Marco Fazzari Andrés Trostchansky Francisco J Schopfer Sonia R Salvatore Beatriz Sánchez-Calvo Dario Vitturi Raquel Valderrama Juan B Barroso Rafael Radi Bruce A Freeman Homero Rubbo |
| author_sort | Marco Fazzari |
| collection | DOAJ |
| description | Extra virgin olive oil (EVOO) and olives, key sources of unsaturated fatty acids in the Mediterranean diet, provide health benefits to humans. Nitric oxide (•NO) and nitrite (NO2 (-))-dependent reactions of unsaturated fatty acids yield electrophilic nitroalkene derivatives (NO2-FA) that manifest salutary pleiotropic cell signaling responses in mammals. Herein, the endogenous presence of NO2-FA in both EVOO and fresh olives was demonstrated by mass spectrometry. The electrophilic nature of these species was affirmed by the detection of significant levels of protein cysteine adducts of nitro-oleic acid (NO2-OA-cysteine) in fresh olives, especially in the peel. Further nitration of EVOO by NO2 (-) under acidic gastric digestive conditions revealed that human consumption of olive lipids will produce additional nitro-conjugated linoleic acid (NO2-cLA) and nitro-oleic acid (NO2-OA). The presence of free and protein-adducted NO2-FA in both mammalian and plant lipids further affirm a role for these species as signaling mediators. Since NO2-FA instigate adaptive anti-inflammatory gene expression and metabolic responses, these redox-derived metabolites may contribute to the cardiovascular benefits associated with the Mediterranean diet. |
| first_indexed | 2024-12-14T18:31:33Z |
| format | Article |
| id | doaj.art-420b2b2b33494c3eaad47a584a8fb675 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-14T18:31:33Z |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-420b2b2b33494c3eaad47a584a8fb6752022-12-21T22:51:46ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0191e8488410.1371/journal.pone.0084884Olives and olive oil are sources of electrophilic fatty acid nitroalkenes.Marco FazzariAndrés TrostchanskyFrancisco J SchopferSonia R SalvatoreBeatriz Sánchez-CalvoDario VitturiRaquel ValderramaJuan B BarrosoRafael RadiBruce A FreemanHomero RubboExtra virgin olive oil (EVOO) and olives, key sources of unsaturated fatty acids in the Mediterranean diet, provide health benefits to humans. Nitric oxide (•NO) and nitrite (NO2 (-))-dependent reactions of unsaturated fatty acids yield electrophilic nitroalkene derivatives (NO2-FA) that manifest salutary pleiotropic cell signaling responses in mammals. Herein, the endogenous presence of NO2-FA in both EVOO and fresh olives was demonstrated by mass spectrometry. The electrophilic nature of these species was affirmed by the detection of significant levels of protein cysteine adducts of nitro-oleic acid (NO2-OA-cysteine) in fresh olives, especially in the peel. Further nitration of EVOO by NO2 (-) under acidic gastric digestive conditions revealed that human consumption of olive lipids will produce additional nitro-conjugated linoleic acid (NO2-cLA) and nitro-oleic acid (NO2-OA). The presence of free and protein-adducted NO2-FA in both mammalian and plant lipids further affirm a role for these species as signaling mediators. Since NO2-FA instigate adaptive anti-inflammatory gene expression and metabolic responses, these redox-derived metabolites may contribute to the cardiovascular benefits associated with the Mediterranean diet.http://europepmc.org/articles/PMC3891761?pdf=render |
| spellingShingle | Marco Fazzari Andrés Trostchansky Francisco J Schopfer Sonia R Salvatore Beatriz Sánchez-Calvo Dario Vitturi Raquel Valderrama Juan B Barroso Rafael Radi Bruce A Freeman Homero Rubbo Olives and olive oil are sources of electrophilic fatty acid nitroalkenes. PLoS ONE |
| title | Olives and olive oil are sources of electrophilic fatty acid nitroalkenes. |
| title_full | Olives and olive oil are sources of electrophilic fatty acid nitroalkenes. |
| title_fullStr | Olives and olive oil are sources of electrophilic fatty acid nitroalkenes. |
| title_full_unstemmed | Olives and olive oil are sources of electrophilic fatty acid nitroalkenes. |
| title_short | Olives and olive oil are sources of electrophilic fatty acid nitroalkenes. |
| title_sort | olives and olive oil are sources of electrophilic fatty acid nitroalkenes |
| url | http://europepmc.org/articles/PMC3891761?pdf=render |
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