Screening for mutation of Decorin gene in simple pathological myopia in Inner Mongolia region
AIM:To investigate the relation of Decorin(DCN)gene and simple pathological myopia in Inner Mongolia region.<p>METHODS:Genomic DNA was collected from 100 control subjects and 100 patients with simple pathological myopia. The exon7 and exon8 and the flanking intron regions of DCN gene were anal...
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| Format: | Article |
| Language: | English |
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Press of International Journal of Ophthalmology (IJO PRESS)
2016-03-01
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| Series: | Guoji Yanke Zazhi |
| Subjects: | |
| Online Access: | http://ies.ijo.cn/cn_publish/2016/3/201603051.pdf |
| _version_ | 1818154488926568448 |
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| author | Yue-Lan Feng Jing Dong Zhi-Ying Liu Jing-Xiao Tang |
| author_facet | Yue-Lan Feng Jing Dong Zhi-Ying Liu Jing-Xiao Tang |
| author_sort | Yue-Lan Feng |
| collection | DOAJ |
| description | AIM:To investigate the relation of Decorin(DCN)gene and simple pathological myopia in Inner Mongolia region.<p>METHODS:Genomic DNA was collected from 100 control subjects and 100 patients with simple pathological myopia. The exon7 and exon8 and the flanking intron regions of DCN gene were analyzed by polymerase chain reaction(PCR)and direct sequencing. The relation of Decorin gene exon7 and exon8 with simple pathological myopia was statistically analyzed.<p>RESULTS:In simple pathological myopia group, 2 patients' gene mutations were identified. Both was 41775T→C,located at the flanking intron regions of exon8. No variation was found in others including control group. The gene mutation between controls and simple pathological myopia groups were not different(<i>P</i>>0.05).<p>CONCLUSION:DNC gene exon7 and exon8 mutation may not be the disease gene in this group in Inner Mongolia region. |
| first_indexed | 2024-12-11T14:27:19Z |
| format | Article |
| id | doaj.art-420b5b58f2c44ec9b94298c55f7062ec |
| institution | Directory Open Access Journal |
| issn | 1672-5123 1672-5123 |
| language | English |
| last_indexed | 2024-12-11T14:27:19Z |
| publishDate | 2016-03-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
| record_format | Article |
| series | Guoji Yanke Zazhi |
| spelling | doaj.art-420b5b58f2c44ec9b94298c55f7062ec2022-12-22T01:02:37ZengPress of International Journal of Ophthalmology (IJO PRESS)Guoji Yanke Zazhi1672-51231672-51232016-03-0116357958110.3980/j.issn.1672-5123.2016.3.51Screening for mutation of Decorin gene in simple pathological myopia in Inner Mongolia regionYue-Lan Feng0Jing Dong1Zhi-Ying Liu2Jing-Xiao Tang3Department of Ophthalmology, the First Affiliated Hospital of Baotou Medical College, Baotou 014010, Inner Mongolia Autonomous Region, ChinaDepartment of Ophthalmology, the First Affiliated Hospital of Baotou Medical College, Baotou 014010, Inner Mongolia Autonomous Region, ChinaDepartment of Ophthalmology, the First Affiliated Hospital of Baotou Medical College, Baotou 014010, Inner Mongolia Autonomous Region, ChinaDepartment of Ophthalmology, the First Affiliated Hospital of Baotou Medical College, Baotou 014010, Inner Mongolia Autonomous Region, ChinaAIM:To investigate the relation of Decorin(DCN)gene and simple pathological myopia in Inner Mongolia region.<p>METHODS:Genomic DNA was collected from 100 control subjects and 100 patients with simple pathological myopia. The exon7 and exon8 and the flanking intron regions of DCN gene were analyzed by polymerase chain reaction(PCR)and direct sequencing. The relation of Decorin gene exon7 and exon8 with simple pathological myopia was statistically analyzed.<p>RESULTS:In simple pathological myopia group, 2 patients' gene mutations were identified. Both was 41775T→C,located at the flanking intron regions of exon8. No variation was found in others including control group. The gene mutation between controls and simple pathological myopia groups were not different(<i>P</i>>0.05).<p>CONCLUSION:DNC gene exon7 and exon8 mutation may not be the disease gene in this group in Inner Mongolia region.http://ies.ijo.cn/cn_publish/2016/3/201603051.pdfsimple pathological myopiaDecorin genemutation |
| spellingShingle | Yue-Lan Feng Jing Dong Zhi-Ying Liu Jing-Xiao Tang Screening for mutation of Decorin gene in simple pathological myopia in Inner Mongolia region Guoji Yanke Zazhi simple pathological myopia Decorin gene mutation |
| title | Screening for mutation of Decorin gene in simple pathological myopia in Inner Mongolia region |
| title_full | Screening for mutation of Decorin gene in simple pathological myopia in Inner Mongolia region |
| title_fullStr | Screening for mutation of Decorin gene in simple pathological myopia in Inner Mongolia region |
| title_full_unstemmed | Screening for mutation of Decorin gene in simple pathological myopia in Inner Mongolia region |
| title_short | Screening for mutation of Decorin gene in simple pathological myopia in Inner Mongolia region |
| title_sort | screening for mutation of decorin gene in simple pathological myopia in inner mongolia region |
| topic | simple pathological myopia Decorin gene mutation |
| url | http://ies.ijo.cn/cn_publish/2016/3/201603051.pdf |
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