Mechanical function of the right ventricle in infants with tetralogy of Fallot
<p><strong>Objective.</strong> The function of the right ventricle (RV) in patients with tetralogy of Fallot (ToF) largely determines the immediate and long-term results of surgical correction of the defect. The aim of this study was to evaluate the mechanical function of RV by ana...
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| Format: | Article |
| Language: | English |
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Meshalkin National Medical Research Center
2015-10-01
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| Series: | Патология кровообращения и кардиохирургия |
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| Online Access: | http://journalmeshalkin.ru/index.php/heartjournal/article/view/234 |
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| author | С. Г. Суханов Е. Н. Орехова Ю. С. Синельников М. С. Суханов |
| author_facet | С. Г. Суханов Е. Н. Орехова Ю. С. Синельников М. С. Суханов |
| author_sort | С. Г. Суханов |
| collection | DOAJ |
| description | <p><strong>Objective.</strong> The function of the right ventricle (RV) in patients with tetralogy of Fallot (ToF) largely determines the immediate and long-term results of surgical correction of the defect. The aim of this study was to evaluate the mechanical function of RV by analyzing the endocardium movement velocity in infants with ToF. <br /><strong>Methods</strong>. The study involved 25 ToF patients 3.9±3 months old and 20 healthy children as the comparison group. The vector analysis used allowed for evaluating longitudinal strain (S) and strain rate (SR) of the right ventricle. <br /><strong>Results</strong>. RV S was lower in ToF patients as compared to healthy ones (-11.7±4.1 against -32.1±3.9%, р <0.05). SR was also significantly reduced in patients with ToF as compared to the healthy ones (-1.4±0.6% against -3.0±0.6%, p<0.05). In patients with ToF RV S was smaller than LV S (-11.7±4.1% against -15±5%, p<0.05). Also reduced was RV SR in patients with ToF both in early diastole (1.5±0.54 vs. 3.2±0.53 s-1, p<0.05), and in late diastole (0.5±0.5 vs. 1.6±0.5 s-1, p<0.05).<br />It was found out that the pulmonic valve gradients correlate with RV S (Rs = 0.89 and 0.8), while inverse correlation was observed between systolic SR and the pulmonary artery trunk and branches. Mechanical remodeling of RV in patients with ToF manifests itself by a decrease in global and regional systolic and diastolic strain. Systolic <br />Conclusion. Systolic mechanical remodeling of RV in ToF patients makes itself evident by a considerable decrease in the velocity of RV global longitudinal systolic deformation in proportion to the degree of obstruction of the outflow tract of the right ventricle. Diastolic mechanical remodeling manifests itself by pronounced impaired relaxation in the form of RV monophasic filling in the early and late diastoles.</p> |
| first_indexed | 2024-03-12T09:35:55Z |
| format | Article |
| id | doaj.art-420cfac43ac64452b1629d5ba7e9f5a5 |
| institution | Directory Open Access Journal |
| issn | 1681-3472 2500-3119 |
| language | English |
| last_indexed | 2024-03-12T09:35:55Z |
| publishDate | 2015-10-01 |
| publisher | Meshalkin National Medical Research Center |
| record_format | Article |
| series | Патология кровообращения и кардиохирургия |
| spelling | doaj.art-420cfac43ac64452b1629d5ba7e9f5a52023-09-02T13:36:30ZengMeshalkin National Medical Research CenterПатология кровообращения и кардиохирургия1681-34722500-31192015-10-01193192510.21688/1681-3472-2015-3-19-25953Mechanical function of the right ventricle in infants with tetralogy of FallotС. Г. Суханов0Е. Н. Орехова1Ю. С. Синельников2М. С. Суханов3ФГБУ «Федеральный центр сердечно-сосудистой хирургии» Минздрава России, 614000, Россия, Пермь, ул. Маршала Жукова, 35ФГБУ «Федеральный центр сердечно-сосудистой хирургии» Минздрава России, 614000, Россия, Пермь, ул. Маршала Жукова, 35ФГБУ «Федеральный центр сердечно-сосудистой хирургии» Минздрава России, 614000, Россия, Пермь, ул. Маршала Жукова, 35ФГБУ «Федеральный центр сердечно-сосудистой хирургии» Минздрава России, 614000, Россия, Пермь, ул. Маршала Жукова, 35<p><strong>Objective.</strong> The function of the right ventricle (RV) in patients with tetralogy of Fallot (ToF) largely determines the immediate and long-term results of surgical correction of the defect. The aim of this study was to evaluate the mechanical function of RV by analyzing the endocardium movement velocity in infants with ToF. <br /><strong>Methods</strong>. The study involved 25 ToF patients 3.9±3 months old and 20 healthy children as the comparison group. The vector analysis used allowed for evaluating longitudinal strain (S) and strain rate (SR) of the right ventricle. <br /><strong>Results</strong>. RV S was lower in ToF patients as compared to healthy ones (-11.7±4.1 against -32.1±3.9%, р <0.05). SR was also significantly reduced in patients with ToF as compared to the healthy ones (-1.4±0.6% against -3.0±0.6%, p<0.05). In patients with ToF RV S was smaller than LV S (-11.7±4.1% against -15±5%, p<0.05). Also reduced was RV SR in patients with ToF both in early diastole (1.5±0.54 vs. 3.2±0.53 s-1, p<0.05), and in late diastole (0.5±0.5 vs. 1.6±0.5 s-1, p<0.05).<br />It was found out that the pulmonic valve gradients correlate with RV S (Rs = 0.89 and 0.8), while inverse correlation was observed between systolic SR and the pulmonary artery trunk and branches. Mechanical remodeling of RV in patients with ToF manifests itself by a decrease in global and regional systolic and diastolic strain. Systolic <br />Conclusion. Systolic mechanical remodeling of RV in ToF patients makes itself evident by a considerable decrease in the velocity of RV global longitudinal systolic deformation in proportion to the degree of obstruction of the outflow tract of the right ventricle. Diastolic mechanical remodeling manifests itself by pronounced impaired relaxation in the form of RV monophasic filling in the early and late diastoles.</p>http://journalmeshalkin.ru/index.php/heartjournal/article/view/234Тетрада ФаллоПравый желудочекПродольная деформацияСкорость деформации |
| spellingShingle | С. Г. Суханов Е. Н. Орехова Ю. С. Синельников М. С. Суханов Mechanical function of the right ventricle in infants with tetralogy of Fallot Патология кровообращения и кардиохирургия Тетрада Фалло Правый желудочек Продольная деформация Скорость деформации |
| title | Mechanical function of the right ventricle in infants with tetralogy of Fallot |
| title_full | Mechanical function of the right ventricle in infants with tetralogy of Fallot |
| title_fullStr | Mechanical function of the right ventricle in infants with tetralogy of Fallot |
| title_full_unstemmed | Mechanical function of the right ventricle in infants with tetralogy of Fallot |
| title_short | Mechanical function of the right ventricle in infants with tetralogy of Fallot |
| title_sort | mechanical function of the right ventricle in infants with tetralogy of fallot |
| topic | Тетрада Фалло Правый желудочек Продольная деформация Скорость деформации |
| url | http://journalmeshalkin.ru/index.php/heartjournal/article/view/234 |
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