Wood cookstove use is associated with gastric cancer in Central America and mediated by host genetics
Abstract Biomass cookstove food preparation is linked to aero-digestive cancers, mediated by ingested and inhaled carcinogens (e.g., heterocyclic amines, and polycyclic aromatic hydrocarbons). We investigated the association between gastric adenocarcinoma, wood cookstove use, H. pylori CagA infectio...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-10-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-42973-7 |
| _version_ | 1797560183965089792 |
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| author | Samara B. Rifkin Anna K. Miller Eleazar E. Montalvan-Sanchez Dalton A. Norwood Enrique Martinez Tim Waterboer T. Mark Beasley Ricardo L. Dominguez Scott M. Williams Douglas R. Morgan |
| author_facet | Samara B. Rifkin Anna K. Miller Eleazar E. Montalvan-Sanchez Dalton A. Norwood Enrique Martinez Tim Waterboer T. Mark Beasley Ricardo L. Dominguez Scott M. Williams Douglas R. Morgan |
| author_sort | Samara B. Rifkin |
| collection | DOAJ |
| description | Abstract Biomass cookstove food preparation is linked to aero-digestive cancers, mediated by ingested and inhaled carcinogens (e.g., heterocyclic amines, and polycyclic aromatic hydrocarbons). We investigated the association between gastric adenocarcinoma, wood cookstove use, H. pylori CagA infection and risk modification by variants in genes that metabolize and affect the internal dose of carcinogens. We conducted a population-based, case–control study (814 incident cases, 1049 controls) in rural Honduras, a high-incidence region with a homogeneous diet and endemic H. pylori infection, primarily with the high-risk CagA genotype. We investigated factors including wood cookstove use, H. pylori CagA serostatus, and 15 variants from 7 metabolizing genes, and the interactions between wood stove use and the genetic variants. Male sex (OR 2.0, 1.6–2.6), age (OR 1.04, 1.03–1.05), wood cookstove use (OR 2.3, 1.6–3.3), and CagA serostatus (OR 3.5, 2.4–5.1) and two SNPs in CYP1B1 (rs1800440 and rs1056836) were independently associated with gastric cancer in multivariate analysis. In the final multivariate model, a highly significant interaction (OR 3.1, 1.2–7.8) was noted between wood cookstove use and the rs1800440 metabolizing genotype, highlighting an important gene-environment interaction. Lifetime wood cookstove use associates with gastric cancer risk in the high-incidence regions of Central America, and the association is dependent on the rs1800440 genotype in CYP1B1. H. pylori CagA infection, wood cookstove use and the rs1800440 genotype, all of which are highly prevalent, informs who is at greatest risk from biomass cookstove use. |
| first_indexed | 2024-03-10T17:56:50Z |
| format | Article |
| id | doaj.art-420d10d5694848409ea9b7bb4a2148e2 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-10T17:56:50Z |
| publishDate | 2023-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-420d10d5694848409ea9b7bb4a2148e22023-11-20T09:10:19ZengNature PortfolioScientific Reports2045-23222023-10-011311910.1038/s41598-023-42973-7Wood cookstove use is associated with gastric cancer in Central America and mediated by host geneticsSamara B. Rifkin0Anna K. Miller1Eleazar E. Montalvan-Sanchez2Dalton A. Norwood3Enrique Martinez4Tim Waterboer5T. Mark Beasley6Ricardo L. Dominguez7Scott M. Williams8Douglas R. Morgan9Department of Gastroenterology and Hepatology, University of MichiganDepartment of Genetics and Genome Sciences, Case Western Reserve UniversityHospital de Occidente, Ministry of Health, Santa Rosa de CopanHospital de Occidente, Ministry of Health, Santa Rosa de CopanHospital EvangelicoInfections and Cancer Epidemiology, German Cancer Research Center (DKFZ)Department of Biostatistics, School of Public Health, The University of Alabama at BirminghamHospital de Occidente, Ministry of Health, Santa Rosa de CopanDepartment of Genetics and Genome Sciences, Case Western Reserve UniversityMedicine and Epidemiology, UAB Division of Gastroenterology and Hepatology, The University of Alabama at Birmingham (UAB)Abstract Biomass cookstove food preparation is linked to aero-digestive cancers, mediated by ingested and inhaled carcinogens (e.g., heterocyclic amines, and polycyclic aromatic hydrocarbons). We investigated the association between gastric adenocarcinoma, wood cookstove use, H. pylori CagA infection and risk modification by variants in genes that metabolize and affect the internal dose of carcinogens. We conducted a population-based, case–control study (814 incident cases, 1049 controls) in rural Honduras, a high-incidence region with a homogeneous diet and endemic H. pylori infection, primarily with the high-risk CagA genotype. We investigated factors including wood cookstove use, H. pylori CagA serostatus, and 15 variants from 7 metabolizing genes, and the interactions between wood stove use and the genetic variants. Male sex (OR 2.0, 1.6–2.6), age (OR 1.04, 1.03–1.05), wood cookstove use (OR 2.3, 1.6–3.3), and CagA serostatus (OR 3.5, 2.4–5.1) and two SNPs in CYP1B1 (rs1800440 and rs1056836) were independently associated with gastric cancer in multivariate analysis. In the final multivariate model, a highly significant interaction (OR 3.1, 1.2–7.8) was noted between wood cookstove use and the rs1800440 metabolizing genotype, highlighting an important gene-environment interaction. Lifetime wood cookstove use associates with gastric cancer risk in the high-incidence regions of Central America, and the association is dependent on the rs1800440 genotype in CYP1B1. H. pylori CagA infection, wood cookstove use and the rs1800440 genotype, all of which are highly prevalent, informs who is at greatest risk from biomass cookstove use.https://doi.org/10.1038/s41598-023-42973-7 |
| spellingShingle | Samara B. Rifkin Anna K. Miller Eleazar E. Montalvan-Sanchez Dalton A. Norwood Enrique Martinez Tim Waterboer T. Mark Beasley Ricardo L. Dominguez Scott M. Williams Douglas R. Morgan Wood cookstove use is associated with gastric cancer in Central America and mediated by host genetics Scientific Reports |
| title | Wood cookstove use is associated with gastric cancer in Central America and mediated by host genetics |
| title_full | Wood cookstove use is associated with gastric cancer in Central America and mediated by host genetics |
| title_fullStr | Wood cookstove use is associated with gastric cancer in Central America and mediated by host genetics |
| title_full_unstemmed | Wood cookstove use is associated with gastric cancer in Central America and mediated by host genetics |
| title_short | Wood cookstove use is associated with gastric cancer in Central America and mediated by host genetics |
| title_sort | wood cookstove use is associated with gastric cancer in central america and mediated by host genetics |
| url | https://doi.org/10.1038/s41598-023-42973-7 |
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