Anti-flagellin antibody responses elicited in mice orally immunized with attenuated Salmonella enterica serovar Typhimurium vaccine strains
In the present study we investigated the flagellin-specific serum (IgG) and fecal (IgA) antibody responses elicited in BALB/c mice immunized with isogenic mutant derivatives of the attenuated Salmonella enterica serovar Typhimurium (S. Typhimurium) SL3261 strain expressing phase 1 (FliCi), phase 2 (...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Fundação Oswaldo Cruz (FIOCRUZ)
2008-09-01
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| Series: | Memorias do Instituto Oswaldo Cruz |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762008000600017 |
| _version_ | 1797704722913689600 |
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| author | LM Massis CJM Braga ME Sbrogio-Almeida C Lauand SMC Newton PE Klebba LCS Ferreira |
| author_facet | LM Massis CJM Braga ME Sbrogio-Almeida C Lauand SMC Newton PE Klebba LCS Ferreira |
| author_sort | LM Massis |
| collection | DOAJ |
| description | In the present study we investigated the flagellin-specific serum (IgG) and fecal (IgA) antibody responses elicited in BALB/c mice immunized with isogenic mutant derivatives of the attenuated Salmonella enterica serovar Typhimurium (S. Typhimurium) SL3261 strain expressing phase 1 (FliCi), phase 2 (FljB), or no endogenous flagellin. The data reported here indicate that mice orally immunized with recombinant S. Typhimurium strains do not mount significant systemic or secreted antibody responses to FliCi, FljB or heterologous B-cell epitopes genetically fused to FliCi. These findings are particularly relevant for those interested in the use of flagellins as molecular carriers of heterologous antigens vectored by attenuated S. Typhimurium strains. |
| first_indexed | 2024-03-12T05:25:38Z |
| format | Article |
| id | doaj.art-420dad4a92e14b059ee498f057cedf1e |
| institution | Directory Open Access Journal |
| issn | 0074-0276 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T05:25:38Z |
| publishDate | 2008-09-01 |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-420dad4a92e14b059ee498f057cedf1e2023-09-03T07:24:44ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz0074-02761678-80602008-09-01103660661010.1590/S0074-02762008000600017Anti-flagellin antibody responses elicited in mice orally immunized with attenuated Salmonella enterica serovar Typhimurium vaccine strainsLM MassisCJM BragaME Sbrogio-AlmeidaC LauandSMC NewtonPE KlebbaLCS FerreiraIn the present study we investigated the flagellin-specific serum (IgG) and fecal (IgA) antibody responses elicited in BALB/c mice immunized with isogenic mutant derivatives of the attenuated Salmonella enterica serovar Typhimurium (S. Typhimurium) SL3261 strain expressing phase 1 (FliCi), phase 2 (FljB), or no endogenous flagellin. The data reported here indicate that mice orally immunized with recombinant S. Typhimurium strains do not mount significant systemic or secreted antibody responses to FliCi, FljB or heterologous B-cell epitopes genetically fused to FliCi. These findings are particularly relevant for those interested in the use of flagellins as molecular carriers of heterologous antigens vectored by attenuated S. Typhimurium strains.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762008000600017fagellinantibody responseattenuated S.Typhimurium strains |
| spellingShingle | LM Massis CJM Braga ME Sbrogio-Almeida C Lauand SMC Newton PE Klebba LCS Ferreira Anti-flagellin antibody responses elicited in mice orally immunized with attenuated Salmonella enterica serovar Typhimurium vaccine strains Memorias do Instituto Oswaldo Cruz fagellin antibody response attenuated S. Typhimurium strains |
| title | Anti-flagellin antibody responses elicited in mice orally immunized with attenuated Salmonella enterica serovar Typhimurium vaccine strains |
| title_full | Anti-flagellin antibody responses elicited in mice orally immunized with attenuated Salmonella enterica serovar Typhimurium vaccine strains |
| title_fullStr | Anti-flagellin antibody responses elicited in mice orally immunized with attenuated Salmonella enterica serovar Typhimurium vaccine strains |
| title_full_unstemmed | Anti-flagellin antibody responses elicited in mice orally immunized with attenuated Salmonella enterica serovar Typhimurium vaccine strains |
| title_short | Anti-flagellin antibody responses elicited in mice orally immunized with attenuated Salmonella enterica serovar Typhimurium vaccine strains |
| title_sort | anti flagellin antibody responses elicited in mice orally immunized with attenuated salmonella enterica serovar typhimurium vaccine strains |
| topic | fagellin antibody response attenuated S. Typhimurium strains |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762008000600017 |
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