Loss of <italic toggle="yes">O</italic>-Linked Protein Glycosylation in <named-content content-type="genus-species">Burkholderia cenocepacia</named-content> Impairs Biofilm Formation and Siderophore Activity and Alters Transcriptional Regulators

Loss of <italic toggle="yes">O</italic>-Linked Protein Glycosylation in <named-content content-type="genus-species">Burkholderia cenocepacia</named-content> Impairs Biofilm Formation and Siderophore Activity and Alters Transcriptional Regulators

ABSTRACT O-linked protein glycosylation is a conserved feature of the Burkholderia genus. The addition of the trisaccharide β-Gal-(1,3)-α-GalNAc-(1,3)-β-GalNAc to membrane exported proteins in Burkholderia cenocepacia is required for bacterial fitness and resistance to environmental stress. However,...

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Bibliographic Details
Main Authors: Cameron C. Oppy, Leila Jebeli, Miku Kuba, Clare V. Oates, Richard Strugnell, Laura E. Edgington-Mitchell, Miguel A. Valvano, Elizabeth L. Hartland, Hayley J. Newton, Nichollas E. Scott
Format: Article
Language:English
Published: American Society for Microbiology 2019-12-01
Series:mSphere
Subjects:
glycosylation
pathogenesis
Burkholderia cenocepacia
posttranslational modifications
proteomics
DNA binding
Online Access:https://journals.asm.org/doi/10.1128/mSphere.00660-19

Internet

https://journals.asm.org/doi/10.1128/mSphere.00660-19

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