Lipid profile in relation to glycemic control in Type 1 diabetes children and adolescents in Bangladesh
Introduction: Dyslipidemia and hyperglycemia are metabolic abnormalities commonly found in young patients with Type 1 diabetes mellitus (T1DM) and both increase the risk of cardiovascular disease. Methods: This cross-sectional study was aimed to evaluate the pattern of dyslipidemia and its relations...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2018-01-01
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| Series: | Indian Journal of Endocrinology and Metabolism |
| Subjects: | |
| Online Access: | http://www.ijem.in/article.asp?issn=2230-8210;year=2018;volume=22;issue=1;spage=89;epage=92;aulast=Zabeen |
| _version_ | 1811265798006636544 |
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| author | Bedowra Zabeen Ana Margarida Balsa Nasreen Islam Mukta Parveen Jebun Nahar Kishwar Azad |
| author_facet | Bedowra Zabeen Ana Margarida Balsa Nasreen Islam Mukta Parveen Jebun Nahar Kishwar Azad |
| author_sort | Bedowra Zabeen |
| collection | DOAJ |
| description | Introduction: Dyslipidemia and hyperglycemia are metabolic abnormalities commonly found in young patients with Type 1 diabetes mellitus (T1DM) and both increase the risk of cardiovascular disease. Methods: This cross-sectional study was aimed to evaluate the pattern of dyslipidemia and its relationship with other risk factors in children and adolescents with T1DM. A total of 576 T1DM patients aged 10–18 years who attended Changing Diabetes in Children, a pediatric diabetes clinic in Bangladesh Institute of Research and Rehabilitation for Diabetes, Endocrine and Metabolic Disorders over 1 year period from July 2015 to June 2016 were included in this study.Results: The overall frequency of dyslipidemia was 65%. The high triglyceride, high cholesterol, high low-density lipoprotein (LDL) and low high-density lipoprotein were found in 50%, 66%, 75%, and 48%, respectively. Compared to patients without dyslipidemia, patients with dyslipidemia had significantly lower mean body mass index (kg/m2) (18.4 [interquartile range; 16.2–21.4] vs. 19.5 [17.3–21.5] (P = 0.005)); significantly higher median fasting blood sugar (12.7 [9.9–15.2] vs. 10.6 [7.9–12.6] (P < 0.0001)) and higher median glycosylated hemoglobin (9.8 [8.4–11.8] vs. 7.9 [9.3–10.5] (P < 0.0001)). Hypertension was significantly higher in dyslipidemic patients (9.4% vs. 2.5% P < 0.002). Conclusion: More than half (65%) of our children and adolescents with T1DM had dyslipidemia, among them high LDL was the most common. These findings emphasize the screening of lipid profile in T1DM children and adolescents. |
| first_indexed | 2024-04-12T20:30:26Z |
| format | Article |
| id | doaj.art-420de3fa6ae7429f94ae1cad19104a90 |
| institution | Directory Open Access Journal |
| issn | 2230-8210 |
| language | English |
| last_indexed | 2024-04-12T20:30:26Z |
| publishDate | 2018-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Endocrinology and Metabolism |
| spelling | doaj.art-420de3fa6ae7429f94ae1cad19104a902022-12-22T03:17:46ZengWolters Kluwer Medknow PublicationsIndian Journal of Endocrinology and Metabolism2230-82102018-01-01221899210.4103/ijem.IJEM_217_17Lipid profile in relation to glycemic control in Type 1 diabetes children and adolescents in BangladeshBedowra ZabeenAna Margarida BalsaNasreen IslamMukta ParveenJebun NaharKishwar AzadIntroduction: Dyslipidemia and hyperglycemia are metabolic abnormalities commonly found in young patients with Type 1 diabetes mellitus (T1DM) and both increase the risk of cardiovascular disease. Methods: This cross-sectional study was aimed to evaluate the pattern of dyslipidemia and its relationship with other risk factors in children and adolescents with T1DM. A total of 576 T1DM patients aged 10–18 years who attended Changing Diabetes in Children, a pediatric diabetes clinic in Bangladesh Institute of Research and Rehabilitation for Diabetes, Endocrine and Metabolic Disorders over 1 year period from July 2015 to June 2016 were included in this study.Results: The overall frequency of dyslipidemia was 65%. The high triglyceride, high cholesterol, high low-density lipoprotein (LDL) and low high-density lipoprotein were found in 50%, 66%, 75%, and 48%, respectively. Compared to patients without dyslipidemia, patients with dyslipidemia had significantly lower mean body mass index (kg/m2) (18.4 [interquartile range; 16.2–21.4] vs. 19.5 [17.3–21.5] (P = 0.005)); significantly higher median fasting blood sugar (12.7 [9.9–15.2] vs. 10.6 [7.9–12.6] (P < 0.0001)) and higher median glycosylated hemoglobin (9.8 [8.4–11.8] vs. 7.9 [9.3–10.5] (P < 0.0001)). Hypertension was significantly higher in dyslipidemic patients (9.4% vs. 2.5% P < 0.002). Conclusion: More than half (65%) of our children and adolescents with T1DM had dyslipidemia, among them high LDL was the most common. These findings emphasize the screening of lipid profile in T1DM children and adolescents.http://www.ijem.in/article.asp?issn=2230-8210;year=2018;volume=22;issue=1;spage=89;epage=92;aulast=ZabeenChildren and adolescentsdyslipidemiaglycemic controltype 1 diabetes |
| spellingShingle | Bedowra Zabeen Ana Margarida Balsa Nasreen Islam Mukta Parveen Jebun Nahar Kishwar Azad Lipid profile in relation to glycemic control in Type 1 diabetes children and adolescents in Bangladesh Indian Journal of Endocrinology and Metabolism Children and adolescents dyslipidemia glycemic control type 1 diabetes |
| title | Lipid profile in relation to glycemic control in Type 1 diabetes children and adolescents in Bangladesh |
| title_full | Lipid profile in relation to glycemic control in Type 1 diabetes children and adolescents in Bangladesh |
| title_fullStr | Lipid profile in relation to glycemic control in Type 1 diabetes children and adolescents in Bangladesh |
| title_full_unstemmed | Lipid profile in relation to glycemic control in Type 1 diabetes children and adolescents in Bangladesh |
| title_short | Lipid profile in relation to glycemic control in Type 1 diabetes children and adolescents in Bangladesh |
| title_sort | lipid profile in relation to glycemic control in type 1 diabetes children and adolescents in bangladesh |
| topic | Children and adolescents dyslipidemia glycemic control type 1 diabetes |
| url | http://www.ijem.in/article.asp?issn=2230-8210;year=2018;volume=22;issue=1;spage=89;epage=92;aulast=Zabeen |
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