Nanomechanical hydrodynamic force sensing using suspended microfluidic channels
Abstract Microfluidics has demonstrated high versatility in the analysis of in-flow particles and can even achieve mechanical properties measurements of biological cells by applying hydrodynamic forces. However, there is currently no available technique that enables the direct measurement and tracki...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2023-05-01
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| Series: | Microsystems & Nanoengineering |
| Online Access: | https://doi.org/10.1038/s41378-023-00531-1 |
| _version_ | 1797827433796206592 |
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| author | Alberto Martín-Pérez Daniel Ramos |
| author_facet | Alberto Martín-Pérez Daniel Ramos |
| author_sort | Alberto Martín-Pérez |
| collection | DOAJ |
| description | Abstract Microfluidics has demonstrated high versatility in the analysis of in-flow particles and can even achieve mechanical properties measurements of biological cells by applying hydrodynamic forces. However, there is currently no available technique that enables the direct measurement and tracking of these hydrodynamic forces acting on a flowing particle. In this work, we introduce a novel method for the direct measurement of the hydrodynamic force actuating on an in-flow particle based on the analysis of the induced resonance changes of suspended microchannel resonators (SMRs). This hydrodynamic force sensitivity depends on the device used; therefore, we considered the geometry and materials to advance this dependency on the SMR resonance frequency. |
| first_indexed | 2024-04-09T12:49:17Z |
| format | Article |
| id | doaj.art-420de957cf5344a38d9496c9ff99a034 |
| institution | Directory Open Access Journal |
| issn | 2055-7434 |
| language | English |
| last_indexed | 2024-04-09T12:49:17Z |
| publishDate | 2023-05-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Microsystems & Nanoengineering |
| spelling | doaj.art-420de957cf5344a38d9496c9ff99a0342023-05-14T11:19:51ZengNature Publishing GroupMicrosystems & Nanoengineering2055-74342023-05-01911810.1038/s41378-023-00531-1Nanomechanical hydrodynamic force sensing using suspended microfluidic channelsAlberto Martín-Pérez0Daniel Ramos1Optomechanics Lab, Instituto de Ciencia de Materiales de Madrid (ICMM-CSIC), 3 Sor Juana Inés de la Cruz (Madrid)Optomechanics Lab, Instituto de Ciencia de Materiales de Madrid (ICMM-CSIC), 3 Sor Juana Inés de la Cruz (Madrid)Abstract Microfluidics has demonstrated high versatility in the analysis of in-flow particles and can even achieve mechanical properties measurements of biological cells by applying hydrodynamic forces. However, there is currently no available technique that enables the direct measurement and tracking of these hydrodynamic forces acting on a flowing particle. In this work, we introduce a novel method for the direct measurement of the hydrodynamic force actuating on an in-flow particle based on the analysis of the induced resonance changes of suspended microchannel resonators (SMRs). This hydrodynamic force sensitivity depends on the device used; therefore, we considered the geometry and materials to advance this dependency on the SMR resonance frequency.https://doi.org/10.1038/s41378-023-00531-1 |
| spellingShingle | Alberto Martín-Pérez Daniel Ramos Nanomechanical hydrodynamic force sensing using suspended microfluidic channels Microsystems & Nanoengineering |
| title | Nanomechanical hydrodynamic force sensing using suspended microfluidic channels |
| title_full | Nanomechanical hydrodynamic force sensing using suspended microfluidic channels |
| title_fullStr | Nanomechanical hydrodynamic force sensing using suspended microfluidic channels |
| title_full_unstemmed | Nanomechanical hydrodynamic force sensing using suspended microfluidic channels |
| title_short | Nanomechanical hydrodynamic force sensing using suspended microfluidic channels |
| title_sort | nanomechanical hydrodynamic force sensing using suspended microfluidic channels |
| url | https://doi.org/10.1038/s41378-023-00531-1 |
| work_keys_str_mv | AT albertomartinperez nanomechanicalhydrodynamicforcesensingusingsuspendedmicrofluidicchannels AT danielramos nanomechanicalhydrodynamicforcesensingusingsuspendedmicrofluidicchannels |