Assessing cancer in people with profound and multiple disabilities
Abstract Background Cancers are as common in individuals with intellectual disabilities as in the general population (GP). For the subgroup of people with profound and multiple disabilities (PMD) who present with both severe intellectual disability and major motor disorders, the frequency and distri...
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| Format: | Article |
| Language: | English |
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BMC
2023-08-01
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| Series: | BMC Cancer |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12885-023-11313-3 |
| _version_ | 1797559013520441344 |
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| author | Daniel Satgé Motoi Nishi Brigitte Trétarre |
| author_facet | Daniel Satgé Motoi Nishi Brigitte Trétarre |
| author_sort | Daniel Satgé |
| collection | DOAJ |
| description | Abstract Background Cancers are as common in individuals with intellectual disabilities as in the general population (GP). For the subgroup of people with profound and multiple disabilities (PMD) who present with both severe intellectual disability and major motor disorders, the frequency and distribution of cancers are currently not known, preventing proper cancer surveillance. Methods We carried out a systematic and synthetic review of the medical literature, including a focused search of Japanese data. Results The total risk of cancer in individuals with PMD is thought to be lower than in the GP, possibly due to a shorter life expectancy. They have reduced exposure to cancer risk factors, such as alcohol, tobacco, sunlight, human papillomavirus infection, occupational toxins, and being overweight. On the other hand, individuals with PMD present a greater frequency of gastroesophageal reflux disease, Helicobacter pylori gastritis, chronic cystitis, and cryptorchidism, which increase the risk for cancer of the esophagus, stomach, urinary bladder, and testes. In addition, certain genetic disorders underlying compromised motor and cognitive functions are associated with higher risk of childhood cancers. An analysis of 135 cancers in persons with PMD in Japan suggested that they present a particular tumor profile, with certain cancers rarer than in the GP, whereas cancers of the digestive tract are frequent. Cancers of the digestive tract occurred significantly earlier than in the GP (colon: average age 48.3 years vs. 71.3 years in the GP, esophagus: 39 years vs. 72 years in the GP). An increasing number of therapeutic successes in children and adults with PMD have been reported in different countries when cancers are discovered early. Conclusion Individuals with PMD must be appropriately monitored for cancer. Screenings for breast and colon cancer, as well as regular monitoring of the esophagus, stomach, urinary bladder, and testicles, are necessary. Population-based epidemiological studies are needed to better understand risk factors, frequency, and distribution of cancers in the PMD population. |
| first_indexed | 2024-03-10T17:39:35Z |
| format | Article |
| id | doaj.art-420eeb33d844400dbe1ea8fbe6552112 |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-03-10T17:39:35Z |
| publishDate | 2023-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-420eeb33d844400dbe1ea8fbe65521122023-11-20T09:44:23ZengBMCBMC Cancer1471-24072023-08-0123111010.1186/s12885-023-11313-3Assessing cancer in people with profound and multiple disabilitiesDaniel Satgé0Motoi Nishi1Brigitte Trétarre2OncodéfiDepartment of Fundamental Health Sciences, Health Sciences University of HokkaidoOncodéfiAbstract Background Cancers are as common in individuals with intellectual disabilities as in the general population (GP). For the subgroup of people with profound and multiple disabilities (PMD) who present with both severe intellectual disability and major motor disorders, the frequency and distribution of cancers are currently not known, preventing proper cancer surveillance. Methods We carried out a systematic and synthetic review of the medical literature, including a focused search of Japanese data. Results The total risk of cancer in individuals with PMD is thought to be lower than in the GP, possibly due to a shorter life expectancy. They have reduced exposure to cancer risk factors, such as alcohol, tobacco, sunlight, human papillomavirus infection, occupational toxins, and being overweight. On the other hand, individuals with PMD present a greater frequency of gastroesophageal reflux disease, Helicobacter pylori gastritis, chronic cystitis, and cryptorchidism, which increase the risk for cancer of the esophagus, stomach, urinary bladder, and testes. In addition, certain genetic disorders underlying compromised motor and cognitive functions are associated with higher risk of childhood cancers. An analysis of 135 cancers in persons with PMD in Japan suggested that they present a particular tumor profile, with certain cancers rarer than in the GP, whereas cancers of the digestive tract are frequent. Cancers of the digestive tract occurred significantly earlier than in the GP (colon: average age 48.3 years vs. 71.3 years in the GP, esophagus: 39 years vs. 72 years in the GP). An increasing number of therapeutic successes in children and adults with PMD have been reported in different countries when cancers are discovered early. Conclusion Individuals with PMD must be appropriately monitored for cancer. Screenings for breast and colon cancer, as well as regular monitoring of the esophagus, stomach, urinary bladder, and testicles, are necessary. Population-based epidemiological studies are needed to better understand risk factors, frequency, and distribution of cancers in the PMD population.https://doi.org/10.1186/s12885-023-11313-3CancerCancer incidenceCancer screeningIntellectual disabilityProfound and multiple disabilities |
| spellingShingle | Daniel Satgé Motoi Nishi Brigitte Trétarre Assessing cancer in people with profound and multiple disabilities BMC Cancer Cancer Cancer incidence Cancer screening Intellectual disability Profound and multiple disabilities |
| title | Assessing cancer in people with profound and multiple disabilities |
| title_full | Assessing cancer in people with profound and multiple disabilities |
| title_fullStr | Assessing cancer in people with profound and multiple disabilities |
| title_full_unstemmed | Assessing cancer in people with profound and multiple disabilities |
| title_short | Assessing cancer in people with profound and multiple disabilities |
| title_sort | assessing cancer in people with profound and multiple disabilities |
| topic | Cancer Cancer incidence Cancer screening Intellectual disability Profound and multiple disabilities |
| url | https://doi.org/10.1186/s12885-023-11313-3 |
| work_keys_str_mv | AT danielsatge assessingcancerinpeoplewithprofoundandmultipledisabilities AT motoinishi assessingcancerinpeoplewithprofoundandmultipledisabilities AT brigittetretarre assessingcancerinpeoplewithprofoundandmultipledisabilities |